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Harris Orthopaedics Laboratory
William Harris, M.D.Director Emeritus, Harris Orthopaedics Laboratory
During Dr. Harris’s 57 year career in Orthopaedic Surgery, he has consistently integrated the art and craft of musculoskeletal surgery with a deep commitment to the improvement of the science of the field, with special emphasis on improving total joint surgery, both clinically and developmentally.
Among levels of clinical improvement, he reported both the lowest sepsis rate and the lowest mortality rate ever published for total hip replacement surgery. Among important concepts, he contributed strongly to the important new critical understanding that most osteoarthritis of the hip is caused by developmental abnormalities, not by a cartilage deficiency. His role in unraveling the mysteries of an entirely new disease “periprosthetic osteolysis” ranged from the initial demonstration of the molecular biology of this disease through establishing the mechanism of the generation of wear particles of polyethylene, followed by the development of a highly crosslinked polyethylene which has virtually eliminated periprosthetic osteolysis worldwide from metal-on-polyethylene total hip replacements.
He made major contributions to the evaluation and quantification of results of hip surgery, allowing much more precise assessments of proposed improvement in designs, materials, or techniques to enable more accurate quantification of the vital distinction between change and progress.
In addition to the key work on identifying major features of the disease “periprosthetic osteolysis” and the prevention of that disease, his work has also reduced the risk of fatal pulmonary emboli and reduced the risk of loosening of components of THA. Moreover, the durability of THA has been greatly extended by his innovations.
His investigation contributed to new understandings in skeletal metabolism, to quantification of the pressure in articular cartilage in vivo in the human acetabulum and to the field of human limb replantation.
He has been honored by receiving two Kappa Delta Awards (the highest award in North America for Orthopaedic Research) and an unprecedented 10 awards from the Hip Society. He was the first surgeon to receive The Lifetime Achievement Award from the Hip Society, the only American to receive the Lifetime Achievement Award from the Muller Foundation and the first Honorary Membership of the International Hip Society.
He founded and directed the Harris Orthopaedic Laboratory at Mass General Hospital, was Chief of the Arthroplasty Service of the Department of Orthopaedic Surgery at Mass General from 1974-2004 and was the Alan Gerry Clinical Professor of Orthopaedic Surgery at Harvard Medical School.
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