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Read more about some of the members of the Harris Orthopaedics Lab.
Dr. Orhun K. Muratoglu is the Director of the Harris Orthopaedics Laboratory and Director of the Technology Implementation Research Center (TIRC) at Massachusetts General Hospital, Alan Gerry Scholar at MGH, and Professor of Orthopedic Surgery at Harvard Medical School.
He received his B.S. from Rennselaer Polytechnic Institute in Materials Science and completed his doctoral work at the Massachusetts Institute of Technology in the Program for Polymer Science and Technology. Dr. Muratoglu played a key role in the discovery of highly crosslinked UHMWPE, a more wear-resistant polymeric material for load-bearing applications in total joints. He also pioneered the use of the antioxidant vitamin E to further stabilize the highly cross-linked UHMWPE. Medical implants fabricated using technologies developed by Dr. Muratoglu have been in clinical use since 1998 with over 7 million implantations worldwide. Dr. Muratoglu continues his research on UHMWPE, and infection and pain management technologies in total joints. He also directs research in the design of more functional joint implants at the TIRC.
Dr. Harris is an internationally recognized expert on the subject of total hip arthroplasty. He founded the Harris Orthopaedics Laboratory (formerly the MGH Orthopaedics Biomechanics and Biomaterials Laboratory, renamed in 2005 to honor Dr. Harris as its Director Emeritus). Dr. Harris is a well-known speaker and author, having published over 500 papers in his 50+ year career. He is also a founding member and first president of the Hip Society, a founding member and past president of the International Hip Society, and the Alan Gerry Clinical Professor of Orthopedic Surgery at the Harvard Medical School.
Dr. Malchau is a Visiting Professor of Orthopaedics Surgery, Joint Arthroplasty, as well as a Staff Surgeon at the MGH. He is one of the founders of the Swedish Hip Registry in Göteborg, Sweden, and is the former director of Orthopaedics at Sahlgrenka Hospital in Göteborg, Sweden.
Dr. Malchau has been an attending surgeon at the Mass General Department of Orthopaedics and was Co-Director of the Harris Orthopaedics Lab for twelve years. His clinical and research interest is focused on documentation of primary and revision hip replacements.
Dr. Malchau has been an active clinician for years, and during the past 21 years he has performed numerous primary and revision hip arthroplasties. He has focused on hip arthroplasty in his postgraduate teaching activities and traveled internationally to share these observations with the orthopedic community. He has tutored several Ph.D. students with the intention of continuing these extremely important educational activities.
Dr. Bichara is responsible for the experimental design and oversight of studies evaluating biocompatibility and in vivo performance of implants engineered in the Harris Laboratory. He has extensive experience developing clinically-relevant models to predict implant performance and determining the biologic effects of implant failure. His research focuses on therapies to treat osteochondral defects using hydrogel-based technologies and strategies to prevent particle-induced osteolysis.
He has authored 19 peer-reviewed publications, has been awarded grants by the American Society of Maxillofacial Surgeons, and currently mentors post-doctoral research fellows and graduate students. After completing clinical clerkships at the Massachusetts General Hospital, Dr. Bichara earned his medical degree from the University of Monterrey, Mexico, graduating cum laude. He is currently a Research Scientist at the Massachusetts General Hospital and an Instructor in Orthopaedics Surgery at Harvard Medical School.
Dr. Bragdon, a member of the Harris Lab for over 35 years, earned his Ph.D. in Clinical Sciences from Göteborg University where he wrote his Ph.D thesis on the methods of measuring wear of polyethylene acetabular components in total hip arthroplasty. His current research is centered on clinical outcomes studies and the clinical performance of new implant materials and prosthetic designs.
He is consistently active in the educational components of this research field, instructing and taking part in educational workshops with orthopedic residents, orthopedic fellows, orthopaedic surgeons, postdoctoral fellows, research fellows, M.D. and PhD candidates, as well as laboratory technicians, technologists and summer interns at Harvard Medical School, the Orthopedic Research Society, and the American Academy of Orthopedic Surgeons.
Dr. Oral received her BS degree from Boğaziçi University in Chemical Engineering. She did her graduate work under the direction of Dr. Nicholas Peppas at Purdue University with specialization in polymeric biomaterials for therapeutic systems and received her PhD in Chemical Engineering in 2003. She did her post-doctoral training in Orthopaedic Biomaterials at the Harris Orthopaedics Laboratory from 2003 to 2005 on antioxidant stabilization methods of cross-linked polyethylenes for joint implants.
Her post-doctoral work received the HAP Paul Award of the International Society for Technology in Arthroplasty. She was appointed an Instructor in 2005 and focused on improving the mechanical strength of current polymeric materials used in joint implants and medical devices. She was named American Academy of Orthopaedics Surgeons/National Institutes of Health Young Investigator on Wear and Osteolysis in 2007 and she again received the HAP Paul Award of the ISTA in 2011. She was named a Claflin Distinguished Scholar at the MGH in 2011 and became a Lifetime Honorary Member of the International Society for Technology in Arthroplasty in 2013.
She was promoted to Assistant Professor in Orthopaedic Surgery at Harvard Medical School in 2013 and focuses on addressing musculoskeletal problems using material strategies while leading the polymeric development work at Harris Orthopaedics Laboratory. She has published over 40 peer-reviewed papers and numerous book chapters. She is also an inventor of a number of material technologies for joint implants with over 90 patents and patent applications. In addition to her research, she is an educator to biomedical engineering technicians, post-doctoral fellows, medical students and colleagues.technicians and technologists.
Dr. Varadarajan received his doctoral degree from the Massachusetts Institute of Technology (MIT), in Mechanical Engineering. Currently he is the Assistant Director for the Technology Implementation Research Center (TIRC) at the Massachusetts General Hospital (MGH), and Instructor in orthopedic surgery at the Harvard Medical School.
At the TIRC, he leads a number of translational research projects aimed at addressing critical challenges in reconstructive surgery through development of better implant designs, and surgical tools. His areas of expertise include human joint biomechanics, computational design, computational analysis pre-clinical testing, and technology development.
Dr. Varadarajan holds over 15 US and international patents related to technologies he has developed through his research at MGH/MIT. He has written chapters on knee joint biomechanics and total knee implant designs for the past two editions of the Orthopaedic Knowledge Update, published by the American Academy of Orthopaedic Surgeons. His research has also resulted in 80+ presentations at national / international conferences, and 23 peer-reviewed journal articles.
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