Physician Photo

Atul K. Bhan, MBBS, MD

Pathologist, Massachusetts General Hospital

Professor of Pathology, Harvard Medical School

Dr. Bhan is a senior pathologist recognized for his diagnostic expertise in breast cancer, and in monitoring transplant and immunodeficiency cases. His current research is focused on IBD and the immunopathogenesis of liver disease.

Departments
Department of Pathology

Specialties

  • Transplant Center
  • Liver Transplant
Clinical Interests
Immunopathology
Autopsy Pathology
Locations
Boston: Massachusetts General Hospital
Medical Education
MD, All India Institute of Medical Sciences
MBBS, Christian Medical College
Residency, Boston Medical Center
Residency, Children's Hospital Boston
Board Certifications
Anatomic Pathology, American Board of Pathology
Immunopathology, American Board of Pathology
Gender
Male
Foreign Languages
Urdu
Patient Age Group
Adult
Accepting New Patients
Yes

Biography

After joining the Immunopathology Unit in 1975, Dr. Bhan performed pioneering work on the application of monoclonal antibodies in the characterization of lymphoid cells in tissues and established the Diagnostic Immunoperoxidase Laboratory in 1981.  Dr. Bhan directed the Immunopathology Unit composed of the Immunoperoxidase, Immunofluorescence, Flow Cytometry, and ANCA laboratories for over 15 years.  Currently, Dr. Bhan is responsible for evaluation of prognostic markers, including hormone receptors and Her-2/neu FISH analysis of breast cancer cases, and peripheral blood lymphocyte monitoring of transplant patients, and immunodeficiency cases by flow cytometry.

Dr. Bhan's major research interests have been the characterization of cell mediated reactions and mucosal immune responses, and defining the pathogenesis of inflammatory bowel disease.  His laboratory has taken a major role in developing experimental models of inflammatory bowel disease using knockout mice.  These studies have demonstrated an important role of the appendix in the development of ulcerative colitis-like inflammation in mice and identified regulatory B cells capable of suppressing mucosal inflammation.  Dr. Bhan is an Associate Director of the NIH-funded, internationally recognized, Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital.  Dr. Bhan is also interested in the immunopathogenesis of liver disease; he has been the pathologist in charge of liver transplant pathology since 1985 and has participated in NIH-supported multicenter studies to evaluate therapy for hepatitis C and hepatitis B.

Research

My research interests are Mucosal Immunology and Inflammatory Bowel Disease. See details at the Bhan Lab.

Publications

View my most recent publications at PubMed

  1. SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine. O'Keeffe MS, Song JH, Liao G, De Calisto J, Halibozek PJ, Mora JR,Bhan AK, Wang N, Reinecker HC, Terhorst C. Gastroenterology. 2015 Feb 10. pii: S0016-5085(15)00168-7. doi: 10.1053/j.gastro.2015.02.003. [Epub ahead of print]
  2. Shear-wave elastography for the estimation of liver fibrosis in chronic liver disease: determining accuracy and ideal site for measurement. Samir AE, Dhyani M, Vij A, Bhan AK, Halpern EF, M?ndez-Navarro J, Corey KE, Chung RT. Radiology. 2015 Mar;274(3):888-96. doi: 10.1148/radiol.14140839. Epub 2014 Nov 13.
  3. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

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Boston, MA 02114-2696

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