Photo of E Tessa  Hedley-Whyte, MD, MBBS

E Tessa Hedley-Whyte, MD, MBBS

  • Pathologist, Massachusetts General Hospital
  • Professor of Pathology, Harvard Medical School


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Dr. Hedley-Whyte provides services to Mass General, and consulting services for patients, physicians and pathologists in the United States and abroad. She further specializes in neurodegenerative diseases in collaboration with the MADRC.



Centers & Specialties

Cancer Center

  • Neuro-Oncology (Brain)
Clinical Interests
  • Neuropathology
  • Autopsy Pathology
  • Frozen Section Pathology
Medical Education
  • MBBS, Kings College @ University of Durham
  • MD, Newcastle University
  • Residency, Children's Hospital Boston
  • Fellowship, Children's Cancer Research Foundation
Board Certifications
  • Anatomic Pathology
  • Neuropathology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - New York
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Dr. E. Tessa Hedley-Whyte is Professor of Pathology specializing in neuropathology and a Principal Investigator in the Massachusetts Alzheimer's Disease Research Center. She is the author of over 150 research papers with topics ranging from pediatric neuropathology, particularly pituitary tumors, to Alzheimer?s disease. She is deeply involved at Harvard Medical School in medical education, assisting in the admission and evaluation of students, and shaping the medical curriculum.

To learn more about her contributions to the field of Pathology and to the Pathology Service at Massachusetts General Hospital, refer to Chapter 17, Neuropathology, from Keen Minds to Explore the Dark Continents of Disease, a book on the Department?s history.

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Research & Publications

Research Summary

Dr. Hedley-Whyte is co-investigator of the Neuropathology Core of the Massachusetts Alzheimer's Disease Research Center (ADRC). The Core's mission is to conduct neuropathological examinations on brains submitted to the Harvard Brain Tissue Resource Center and distribute tissue to ADRC investigators. The ADRC includes investigators with expertise in neuropathology, morphometry, immunocytochemistry, microarray technology, gene chip applications, laser capture techniques and in situ hybridization, and brain banking procedures. With Dr. Matthew Frosch, we use procedures to enhance the value of the brain tissues to investigators whose specific research projects depend upon receiving carefully prepared and diagnosed tissue. Standardized protocols for tissue acquisition, and dissection procedures ensure complete and reproducible examinations across all cases. The Tissue Resource Center maintains a rich collection of paraffin blocks with frozen, and formalin-fixed tissue. Frozen tissue is available as small blocks, and thin whole coronal brain slices, in which all anatomical structures are clearly visible. Separate databases within the Harvard Brain Tissue Resource Center contain information on tissue availability, location, and investigator allocation.

Dr. Hedley-Whyte's other research interests include predictive histological markers of pituitary tumor behavior.


View my most recent publications at PubMed

  1. Pathologic and clinical features of pituitary adenomas showing TSH immunoreactivity. Tritos NA, Eppakayala S, Swearingen B, Hedley-Whyte ET, Miller KK, Nachtigall LB, Grinspoon SK, Biller BM, Klibanski A. Pituitary. 2013 Sep; 16(3):287-93.
  2. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. N Engl J Med. 2013 May 23; 368(21):1992-2003
  3. Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications. Aizer AA, Sethi RV, Hedley-Whyte ET, Ebb D, Tarbell NJ, Yock TI, Macdonald SM. Neuro Oncol. 2013 Jul; 15(7):955-60.

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Massachusetts General Hospital
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-5154617-724-1465
Fax: 617-724-1813

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