Professor of Pathology
Harvard Medical School
Dr. Sgroi is a Professor of Pathology at Harvard Medical School, the Director of Breast Pathology and a Member and Principal Investigator in the Division of Molecular Pathology Research and Center for Cancer Research at the Massachusetts General Hospital. Dr Sgroi received his undergraduate degree from Bowdoin College and his medical degree from the University of Connecticut School of Medicine. After completing a residency in anatomic pathology at Massachusetts General Hospital, Dr Sgroi completed a postdoctoral research fellowship in molecular pathology under the direction of Dr. Ivan Stamenkovic at Massachusetts General Hospital. His laboratory investigates the molecular genetic basis of human breast cancer and has utilized gene expression and proteomic technologies to better understand breast cancer progression. Dr Sgroi has shown that gene expression alterations are powerful predictors of breast cancer outcome and therapeutic response. His laboratory is currently focusing on determining the clinical utility of the HOXB13:IL17BR and MGI biomarkers in estrogen receptor-positive,lymph node negative breast cancer patients, and understanding the molecular functional role of HOXB13 and IL17BR as it relates to anti-hormonal therapeutic response.
ResearchHuman Breast Cancer Anti-Hormonal Resistance
See details at the Sgroi Lab.
PublicationsBibliography of Dennis C. Sgroi via PubMed
A comparison of three methods of predicting recurrence risk in women treated for estrogen-receptor-positive breast cancer finds that only the breast cancer index – a biomarker based on the expression levels of seven tumor-specific genes – accurately identifies patients who continue to be at risk after five years of estrogen-blocking treatment.