Physician Photo

James R. Stone, MD, PhD

Associate Pathologist, Massachusetts General Hospital

Subspecialty Head, Cardiovascular Pathology and Autopsy Service

Associate Professor of Pathology, Harvard Medical School

Dr. Stone directs the Autopsy Service and Cardiovascular Surgical Pathology Service at Mass General. He is head of the Cardiovascular Histology Core Facility, a core laboratory for NIH-funded multicenter trials relating to cardiovascular diseases.

Department of Pathology


  • Transplant Center
  • Heart Transplant
Clinical Interests
Cardiovascular pathology
Autopsy Pathology
Boston: Massachusetts General Hospital
Medical Education
MD, PhD, University of Michigan Medical School
Residency, Brigham and Women's Hospital
Board Certifications
Anatomic Pathology, American Board of Pathology
Patient Age Group
Accepting New Patients
Accepting New Patients


Dr. Stone has published extensively on cardiovascular diseases including atherosclerosis, vasculitis, amyloidosis, and cardiomyopathies. He is a founding co-chair of the Standards and Definitions Committee of the Society for Cardiovascular Pathology, and directs the core laboratory of an NIH-funded multi-center study of cardiac allograft rejection.  He is a member of the Center for Systems Biology, where his laboratory studies basic mechanisms relating to the cellular and molecular biology of cardiovascular diseases


My lab focuses on elucidating the mechanisms of cardiac and vascular diseases. We are working to understand the biochemical processes resulting in atherosclerosis. Investigations are focused on signal transduction mechanisms responsible for the pre-atherosclerotic intimal hyperplasia, and the factors stimulating the formation of intimal necrotic/lipid cores. For more details, visit the Stone Lab. For information about research concepts, co-authors, and to see a timeline, visit Dr. Stone's profile at the Harvard Clinical and Translational Science Center.


View my most recent publications at PubMed

  1. Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury. Elder GA, Gama Sosa MA, De Gasperi R, Stone JR, Dickstein DL, Haghighi F, Hof PR, Ahlers ST. Front Neurol. 2015 Mar 16;6:48. doi: 10.3389/fneur.2015.00048. eCollection 2015.
  2. Chronic mesenteric ischemia., Wilkins LR, Stone JR. Tech Vasc Interv Radiol. 2015 Mar;18(1):31-7. doi: 10.1053/j.tvir.2014.12.005. Epub 2014 Dec 29.
  3. Acute mesenteric ischemia. Stone JR, Wilkins LR. Tech Vasc Interv Radiol. 2015 Mar;18(1):24-30. doi: 10.1053/j.tvir.2014.12.004. Epub 2014 Dec 29.

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-2967
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