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Anat O. Stemmer-Rachamimov, MD

Associate Pathologist, Massachusetts General Hospital

Associate Professor in Pathology, Harvard Medical School

Dr. Stemmer-Rachamimov is an attending pathologist on the Neuropathology and Autopsy services of Pathology, and is a member of the diagnostic staff of the Cogan Laboratory of Ophthalmic Pathology at Massachusetts Eye and Ear Infirmary.

Department of Pathology


  • Cancer Center
  • Neuro-Oncology (Brain)
Clinical Interests
Autopsy Pathology
Frozen Section Pathology
Molecular pathology
Ophthalmic pathology
Boston: Massachusetts General Hospital
Medical Education
MD, University of Milan
Residency, Memorial Hospital Health Science Centre, St. John's
Residency, University Hospital
Fellowship, Massachusetts General Hospital
Board Certifications
Anatomic Pathology, American Board of Pathology
Neuropathology, American Board of Pathology
Foreign Languages
Patient Age Group
Accepting New Patients
Accepting New Patients


Anat Stemmer-Rachamimov, MD, is a faculty member of the C. S. Kubik Laboratory for Neuropathology. She is associate director of the Cogan Laboratory of Ophthalmic Pathology with Director Frederick A. Jakobiec, MD, at Mass Eye and Ear, providing diagnostic services, instruction to trainees on the Neuropathology service through didactic teaching sessions and routine sign-out procedures. She is a consulting pathologist with the Specialized Histopathology Services Core for DF/HCC investigators.

Her conference activities may include weekly or monthly conferences with Pathology, Neurology and Neuro-Oncology. She has particular interest in weekly consensus review sessions in which all primary brain tumors are discussed, along with cases of complexity or particular interest. This session allows the neuropathology staff to maintain a consistent set of diagnostic criteria and terminology.

She is one of four neuropathologists that diagnose approximately 700 in-house surgical neuropathology cases, and 500 consultation cases per year. In a given year, over 900 intra-operative diagnostic consultations are processed. The surgical Opththalmic Pathology team processes over 1,500 cases per year.
Her research interests focus on identifying the underlying molecular changes in the lesions and malformations associated with hereditary brain tumor syndromes such as neurofibromatosis 1, neurofibromatosis 2, schwannomatosis, and tuberous sclerosis.


Our lab's research focuses on identifying the underlying molecular changes in the lesions and malformations associated with hereditary brain tumor syndromes (neurofibromatosis 1, neurofibromatosis 2, schwannomatosis and tuberous sclerosis), and the identification of activated pathways or events that lead to tumor progression. We are now moving from defining the molecular features and understanding the biology to more practical translational research of biomarkers and drug screens.

See details at the Stemmer-Rachamimov Lab.


View my most recent publications at PubMed

  1. Failure to Detect Human Papillomavirus in Focal Cortical Dysplasia Type IIb.
    Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-RachamimovA, Staley KJ. Ann Neurol. 2015 Apr 20.[Epub ahead of print]
  2. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP. Acta Neuropathol Commun. 2014 Dec 24;2:167.
  3. Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. Taylor JW, Dietrich J, Gerstner ER, Norden AD, Rinne ML, Cahill DP,Stemmer-Rachamimov A, Wen PY, Betensky RA, Giorgio DH, Snodgrass K, Randall AE, Batchelor TT, Chi AS. J Neurooncol. 2015 Feb;121(3):557-63. doi: 10.1007/s11060-014-1667-z. Epub 2014 Nov 20.

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