Physician Photo

John M. Higgins, MD

Assistant Pathologist, Massachusetts General Hospital

Assistant Professor of Systems Biology, Harvard Medical School

Dr. Higgins is a hematology specialist in the Core Laboratory of the Mass General Hospital Pathology service. He was a recent recipient of the annual NIH Director's New Innovator Award.

Department of Pathology
Clinical Interests
Clinical Immunology
Hemoglobin Electrophoresis
Boston: Massachusetts General Hospital
Medical Education
MD, Harvard Medical School
Residency, Brigham and Women's Hospital
Fellowship, Brigham and Women's Hospital
Board Certifications
Clinical Pathology, American Board of Pathology
Patient Age Group
Accepting New Patients
Accepting New Patients


John Higgins, MD, is an Assistant Pathologist specializing in the interpretation of clinical immunology and hematology tests.  He is an Assistant Professor of Systems Biology at Harvard Medical School and has a research program developing mathematical models of disease processes with the goal of advancing science and providing new methods of diagnosis, patient monitoring, and treatment discovery.  Dr. Higgins was trained in clinical pathology at Brigham and Women's Hospital and has been on the staff of the Department of Pathology since 2009.


Dr. Higgins studies the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.

See details at the Higgins Lab.


Higgins JM, Mahadevan L
Physiological and pathological population dynamics of circulating human red blood cells. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20587-92. Epub 2010 Nov 8. PubMed PMID: 21059904.

Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J
Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses. Am Heart J. 2010 Mar;159(3):428-33. PubMed PMID: k20211305

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L
Statistical dynamics of flowing red blood cells by morphological image processing.
PLoS Comput Biol. 2009;5(2):e1000288 - PMID: 19214200 - PMCID: PMC2631282

Higgins JM, Sloan SR
Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders.
Blood. 2008;112(6):2546-53 - PMID: 18535200

Higgins JM, Eddington DT, Bhatia SN, Mahadevan L
Sickle cell vasoocclusion and rescue in a microfluidic device.
P Natl Acad Sci U S A. 2007;104(51):20496-500 - PMID: 18077341 - PMCID: PMC2154459

Major NIH grants support innovative research projects

Two MGH-led research teams and one MGH investigator have received major grants from the National Institutes of Health.

Decreased red blood cell clearance appears to predict development and worsening of serious diseases

MGH investigators have found the probable mechanism underlying a previously described biomarker associated with the risk of developing serious diseases ranging from cancer to cardiovascular disease and the risk of serious complications.

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-643-6129