Photo of John M. Higgins, MD

Higgins, John M., MD

  • Assistant Pathologist, Massachusetts General Hospital
  • Associate Professor of Systems Biology, Harvard Medical School


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Dr. Higgins is a hematology specialist in the Core Laboratory of the Mass General Hospital Pathology service. He was a recent recipient of the annual NIH Director's New Innovator Award.



Clinical Interests
  • Clinical Immunology
  • Hemoglobin Electrophoresis
  • Coagulation
Medical Education
  • MD, Harvard Medical School
  • Residency, Brigham and Women's Hospital
  • Fellowship, Brigham and Women's Hospital
Board Certifications
  • Clinical Pathology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group


John Higgins, MD, is an Assistant Pathologist specializing in the interpretation of clinical immunology and hematology tests.  He is an Associate Professor of Systems Biology at Harvard Medical School and has a research program developing mathematical models of disease processes with the goal of advancing science and providing new methods of diagnosis, patient monitoring, and treatment discovery.  Dr. Higgins was trained in clinical pathology at Brigham and Women's Hospital and has been on the staff of the Department of Pathology since 2009.

Research & Publications

Research Summary

Dr. Higgins studies the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.

See details at the Higgins Lab.


View a complete list of Dr. Higgins' publications on the Center for Systems Biology website.

  1. Patel H, Patel H, Higgins JM. Modulation of Red Blood Cell Population Dynamics is a Fundamental Homeostatic Response to Disease. American Journal of Hematology. 2015 Feb 18
  2. Malka R, Delgado FF, Manalis SR, Higgins JM.  In Vivo Volume and Hemoglobin Dynamics of Human Red Blood Cells. PLoS Computational Biology, 10:e1003839 (2014).
  3. Higgins, JM* Mahadevan, L. Physiological and pathological population dynamics of circulating human red blood cells.  Proceedings of the National Academy of Sciences of the United States of America 107:20587-20592 (2010).
  4. Higgins JM and Sloan SR. Stochastic Modeling of Human RBC Alloimmunization: Evidence for a Distinct Population of Immunologic Responders. Blood. 112:2546-53 (2008).

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Pathology Associates
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-643-6129

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