Atul K. Bhan, MBBS, MD

Bhan Lab

“Researching mucosal immunology and inflammatory bowel disease...”

Phone: 617-726-2588

E-mail me

Overview

Atul K. Bhan, MBBS, MD

Professor of Pathology, Harvard Medical School
Pathologist, Massachusetts General Hospital
Massachusetts General Hospital
55 Fruit Street
Warren Building, Room 501
Boston, MA 02114
Phone: 617-726-2588
Fax: 617-726-2365
Email: abhan@mgh.harvard.edu

Overview

In the two major forms of IBD, Crohn’s disease and ulcerative colitis the underlying etiological factors and the pathogenesis remain poorly defined. It is generally believed that exaggerated immune responses to luminal normal enteric flora are involved in the initiation and perpetuation of the disease process.

The availability of a wide variety of experimental models of intestinal inflammation has helped provide important clues about the pathogenesis of IBD. The commonly used models include chemically induced mucosal injury and colitis induced by the transfer of selected populations of T cells into immunodeficient mice. The spontaneous development of colitis in genetically engineered animal models has provided excellent experimental models to study the pathogenesis of IBD. One important lesson learned from IBD models is that many different immunologic and mucosal defects can lead to similar pathologic findings.

For the last several years, our laboratory has focused on defining the pathogenesis of chronic intestinal inflammation using TCR alpha KO mice as a model of human IBD. TCR alpha KO mice develop spontaneously chronic colitis with many features of ulcerative colitis. We have identified a regulatory B cell subset, which appears under chronic intestinal inflammatory conditions and suppresses the progression of intestinal inflammation by secreting IL-10. TCR alpha KO mice deficient in both IL-4 and B cells, but not in IL-4 alone, develop granulomatous colitis with features of Crohn’s disease. This suggests that differences in the two major forms of IBD may reflect different immunological responses to similar initiating events.

The laboratory is closely associated with the Center for the Study of Inflammatory Bowel Disease at MGH and collaborates with the other members of the Center; Dr. Bhan is an Associate Director of the Center. In collaboration with Dr. Terhorst and Dr. Xavier we have studied the role of Th-1 and Th-17 pathways, innate immune system and autophagy in the development of intestinal inflammation. Collaborative studies with Dr. Scott Snapper’s laboratory have shown that interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. The studies with Dr. Richard Hodin’s laboratory indicate that administration of intestinal alkaline phosphatase may have a beneficial effect in intestinal inflammatory conditions and metabolic syndromes. Dr. Bhan’s consultant role in the newly established Harvard Institute of Translational Immunology-Helmsley Pilot Program in Crohn’s Disease has led to his collaboration with Dr. Vijay Yajnik at MGH and Dr. Matthew Myerson at DFCI to identify microorganisms in Crohn’s disease lesions.

Group Members

Atul K. Bhan, MBBS, MD

Research Projects

For the last several years, our laboratory has focused on defining the pathogenesis of chronic intestinal inflammation using TCR alpha KO mice as a model of human IBD. TCR alpha KO mice develop spontaneously chronic colitis with many features of ulcerative colitis. These features include restriction of inflammation to the colon and the mucosa, presence of autoantibodies, the protective role of appendectomy and pathogenic role of Th-2 pathway in the development of colitis. We have identified a regulatory B cell subset, which appears under chronic intestinal inflammatory conditions and suppresses the progression of intestinal inflammation by secreting IL-10. Recently, we have identified an IL-12-producing regulatory B cell subset. TCR alpha KO mice deficient in both IL-4 and B cells, but not in IL-4 alone, develop granulomatous colitis with features of Crohn’s disease. This suggests that differences in the two major forms of IBD may reflect different immunological responses to similar initiating events.

 

Publications

Bibliography of Atul Bhan via PubMed

Lassen KG, McKenzie CI, Mari M, et al.  Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk.  Immunity. 2016 (in press).

Lassen KG, Kuballa P, Conway KL, et al. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A 2014;111:7741-6.

Shouval DS, Biswas A, Goettel JA, et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014;40:706-19.

Kaliannan K, Hamarneh SR, Economopoulos KP, et al. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2013;110:7003-8.

Chang SY, Song JH, Guleng B, et al. Circulatory antigen processing by mucosal dendritic cells controls CD8+ T cell. Immunity. 2013;38:153-165.

Yilmaz OH, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 2012;486:490-5.

Sugimoto K, Ogawa A, Shimomura Y, et al. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology. 2007;133:124-36.

Mizoguchi A, Ogawa A, Takedatsu H, et al. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest. 2007;117:605-615.

Contact

Contact Us

Bhan Laboratory

Massachusetts General Hospital

55 Fruit StreetPathology Service, WRN 501 Boston, MA 02114
  • Phone: 617-726-2588
  • Fax: 617-726-2365

Email: abhan@partners.org

Phone: 617-726-2588

E-mail me

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