Aryee Lab

Martin J. Aryee, PhD, Computational Methods for Genomics and Epigenomics



lab Websites

Martin J. Aryee, PhD

Assistant Pathologist
Massachusetts General Hospital

Assistant Professor of Pathology
Harvard Medical School

Research Interests

Epigenetic mechanisms involve chemical and physical changes to the structure of DNA without changes in the underlying sequence.  Epigenetics allows for fine-tuned control of gene expression and is the basic mechanism whereby a single human genome can give rise to over 200 different cell types in the adult organism. I am interested in the interplay between genetic and epigenetic factors, and their role in determining cell state and disease etiology. My research involves developing statistical tools for mapping genomic and epigenomic landscapes and using this data to understand causes of human disease.