Suvà Lab

Mario L. Suvà is an assistant professor of pathology at Massachusetts Hospital, and a Broad Institute-associated scientist. His most recent work is related to glioblastoma tumors.

Phone: 617-726-5156


One focus of the Suvà lab is studying the genetic epigenesis of glioblastoma tumors. 

Group Members



lab Websites

Mario L. Suvà, MD, PhD

Assistant Molecular Pathologist
Pathology Research
Massachusetts General Hospital

Assistant Professor of Pathology
Harvard Medical School











  1. Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML*, Regev A*, Bernstein BE*. Single-cell RNA-seq highlights intra-tumoral heterogeneity in primary glioblastoma. Science 2014 Jun 12.
  2. Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Riggi N, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek A, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE. Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells. Cell. 2014 Apr 24;157(3):580-94.
    Featured article of the issue and Leading Edge Preview by Gronych J, Pfister SM, Jones DT. Connect four with glioblastoma stem cell factors. Cell. 2014 Apr 24;157(3):525-7
  3. Rheinbay E*, Suvà ML* , Gillespie SM, Wakimoto H, Patel AP, Shahid M, Oksuz O, Rabkin SD, Martuza RL, Rivera MN, Louis DN, Kasif S, Chi AS, Bernstein BE. Chromatin profiles reveal an aberrant transcription factor network connected to Wnt signaling and essential for glioblastoma stem cell maintenance. Cell Reports. 2013 May 30;3(5):1567-79.
  4. Suvà ML, Riggi N and Bernstein BE. Epigenetic reprogramming in cancer. Science. 2013 Mar 29;339(6127):1567-70.
  5. Janiszewska M*, Suvà ML*, Riggi N, Houtkooper RH, Auwerx J, Clément-Schatlo V, Radovanovic I, Rheinbay E, Provero P, Stamenkovic I. Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes & Development. 2012 Sep 1;26(17):1926-44.

Phone: 617-726-5156

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