Kamran Badizadegan, M.D.

Assistant Professor of Pathology, Harvard Medical School
Assistant Pathologist, Gastrointestinal and Pediatric Pathology,
Massachusetts General Hospital

Pathology Service
Gastrointestinal and Pediatric Pathology
Massachusetts General Hospital
55 Fruit Street – WRN219
Boston, MA 02114

Tel: 617-726-6710
Fax: 617-726-7474
Email: kbadizadegan@partners.org

Affiliations:
Visiting Scientist, GR Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology.
Affiliated Faculty, Harvard-MIT Division of Health Sciences and Technology (HST) and Course Director,
HST.035 Principles and Practice of Human Pathology.

Signout: gastrointestinal pathology, consultation in pediatric pathology.

Research:

Lipid rafts have been implicated in a variety of cellular functions including signal transduction and vesicular trafficking. With the exception of caveolae, little is known about specific structural and functional associations in lipid rafts. Using cholera toxin as a model of lipid raft function in intestinal epithelial cells, we have shown significant structural and function heterogeneity within lipid rafts. Furthermore, we have identified the actin cytoskeleton as one of the possible determinant of structural and functional heterogeneity within the rafts. Ongoing studies will determine how a lipid-associated signal (such as the cholera toxin) on the exoplasmic leaflet of the plasma membrane communicates with the actin cytoskeleton on the cytoplasmic leaflet of the plasma membrane lipid rafts.

Dr. Badizadegan’s collaboration with the Spectroscopy Laboratory at MIT has focused on the use of optical spectroscopy in the diagnosis of neoplastic lesions in humans, as well as developing optical spectroscopic methods for the study of cells and cellular functions in vitro. Dr. Badizadegan is the Co-PI (with Professor Michael Feld, Director of the Spectroscopy Lab) on a multi-institutional Bioengineering Research Partnership that aims to develop and test spectroscopic imaging devices and diagnostic algorithms for neoplastic lesions of the cervix and the oral cavity. In addition to these translational studies, Dr. Badizadegan and Professor Feld closely collaborate on the development and testing of spectroscopic techniques for the study of cellular structure and function in living cells.

Bibliography of Kamran Badizadegan via Pubmed (will open in new window)