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Stuart
L. Houser, M.D.
Assistant
Professor of Pathology, Harvard Medical School
Assistant Pathologist, Massachusetts General Hospital
Department of Pathology – WRN 2
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114
Phone: 617-724-7810
Fax: 617-726-7474
Email:
shouser@partners.org |
Signout:
Cardiovascular and lung pathology, and autopsies.
Research Interests:
Our lab is involved in a unique study
of vasculopathy, which developed in xenograft hearts
in a pig-to-baboon model of transplantation. Using
immunohistochemical tissue staining techniques, we
have observed that endothelium in these grafts is
partially replaced by host-derived endothelial cells.
We hypothesize that subsequent activation of these
host-derived endothelial cells may set the stage for
the development of lesions of graft atherosclerosis
(chronic rejection). Further study of this experimental
model may contribute to the understanding of the pathogenesis
of this disease in human allografts, which, to date,
has proved less susceptible to therapy than acute
cellular rejection.
This effort to characterize vasculopathy in transplanted
hearts has been funded by three separate grants and
has resulted in more than thirty publications in the
span of four years. We have incorporated the use of
histopathology, molecular techniques, and digital
morphometry in studies done with a group of investigators,
including immunologists, molecular biologists, and
surgeons at our Transplantation Biology Research Center
in Charlestown.
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