Sign
out: Obstetric pathology, fetal pathology,
neonatal autopsies, maternal autopsies, GYN pathology.
Research:
The Roberts lab uses the chick embryo
as a model system to study the molecular controls
of organogenesis and patterning with specific focus
on the gut and lung. The lab does some translational
work studying the expression of factors in human tissues.
The research uses a retroviral misexpression system,
electroporation, transplants, RNAi, and organ cultures
to alter expression of candidate factors important
in pattern formation of the gut, lung and the ENS.
Histology and gene expression studies on the phenotypes
obtained are used to develop models for pathways used
in development. Translational work studies expression
of these factors in tissues from human malformation
syndromes (congenital diaphragmatic hernia) and disorders
(Hirschprung’s disease and intestinal neuronal
dysplasia). Clinical studies emphasize placental pathology
with specific interests in neonatal outcome and effects
of alcohol exposure in utero to the placenta and fetus.
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