 |
Patrick
M. Sluss, Ph.D.
Assistant
Professor
Harvard Medical School
Associate Director
Clinical Chemistry Laboratory
Massachusetts General
Hospital
Bulfinch 051
55 Fruit Street
Boston, MA 02114
Phone:
617-726-4352
Fax: 617-726-9330
Email:
psluss@partners.org |
Research:
Basic investigations of the biochemistry,
physiology and pathophysiology of the activin-binding
protein follistatin. Recent studies have focused upon
identifying the specific epitopes directly involved
with activin binding and delineating allosteric effects
of activin binding in altering domain-specific antigenic
epitopes in the holoprotein. In addition, his lab
is involved in clinical studies directed toward developing
methods and technological approaches for serum measurements
of novel ovarian cancer markers using SELDI and other
high resolution proteomic procedures. Finally, his
lab conducts studies of current and new immunodiagnostic
methods to evaluate their analytical performance and
clinical utility. These studies encompass immunoassays
for endocrine hormones, tumor markers, cardiac markers,
and therapeutic drugs. |
