Department of Pharmacy
Department of Nursing
Critical Care
| Generic Name: | Tromethamine, Tris Buffer |
| Trade Name: | Tham |
| Action: | Organic proton acceptor (buffer) |
| Indications: | Metabolic Acidosis |
| Administration Guidelines: | |
| Usual Dose and Route: | Dose in ml’s of Tromethamine of 0.3M
solution (premixed) = body wt in kg X base deficit in MEq/l (calculated by lab upon
request) Total dose should be administered over a period not less than 1 hour |
| Standard concentration: | Central line=0.3M solution (premixed) =300mM/liter |
| Special Considerations: | Frequent ECG and potassium monitoring Contrindicated in chronic repiratory acidosis and uremia/anuria |
| Precautions and Side Effects: | Renal Failure Hyperkalemia Electrolyte disturbances Hypoglycemia |
REV:Apr-98