Physician Photo

James Benjamin (James) Meigs, MD

Physician, Massachusetts General Hospital

  • Phone: 617-724-2700
Primary Care
Department of Medicine
Clinical Interests
Internal Medicine
Primary Care Medicine
Boston: Massachusetts General Hospital
Medical Education
MD, Harvard Medical School
Residency, Massachusetts General Hospital
Fellowship, Massachusetts General Hospital
Board Certifications
Internal Medicine, American Board of Internal Medicine
Patient Age Group
Accepting New Patients
Not Accepting New Patients


JamesB. Meigs MD, MPH is Professor of Medicine at Harvard Medical School,Physician, Division of General Internal Medicine, Massachusetts GeneralHospital and Co-Director of the MGH Clinical Research Program?s ClinicalEffectiveness Research Group.

For over 25 years Dr. Meigs has been a practicing primary care general internist in the MGH Internal Medicine Associates. 

Dr. Meigs' research interest for over 20 years has beenthe cause and prevention of type 2 diabetes and cardiovascular disease. He has authored more than 400 peer-reviewed scientific papers (Thomson Reuters Highly Cited Researcher 2014), supported by multiple NIH andfoundation research grants, currently including 2R01 DK078616: Common Genetic Variation and DiabetesQuantitative Traits (PI), U01DK085526: Multiethnic Study of Type 2Diabetes Genetics (Co-PI) and K24DK080140: Epidemiology of Precursors toType 2 Diabetes (PI). He is a senior scientific leader of several largeinternational type 2 diabetes-related genetic consortia, including MAGIC (MetaAnalysis of Glucose and Insulin Consortium), AAGILE (African American Glucoseand Insulin genetic Epidemiology) and CHARGE (Cohorts for Heart and AgingGenetic Epidemiology).

Dr. Meigs has mentored over 50 junior clinical researchinvestigators, supported in part by the NIDDK K24 award. In 2009, he wasawarded the American Diabetes Association?s Kelly West Award for OutstandingAchievement in Diabetes Epidemiology.

ResearchDr. Meigs' research interest for more than 20 years has been the cause and prevention of type 2 diabetes and cardiovascular disease using molecular and genetic epidemiology and translational health services research approaches. He has authored more than 400 peer-reviewed scientific papers, supported by multiple National Institutes of Health and foundation research grants.


Selected publications:

  1. Berkowitz SA, Meigs JB, Wexler DJ. Age at type 2 diabetes onset and glycaemic control: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2010. Diabetologia. 2013 Sep 1. [Epub ahead of print] PMID: 23995472
  2. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44. PMID: 24509480
  3. Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB. Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes. 2014 Feb 11. [Epub ahead of print] PMID: 24520119
  4. Cornes BK, Brody JA, Nikpoor N, Morrison AC, Dang HCP, Ahn BS, Wang S, Dauriz M, Barzilay JI, Dupuis J, Florez JC, Coresh J, Gibbs RA, Kao WHL, Liu C-T, McKnight B, MuznyD, Pankow JS, Reid JG, White CC, Johnson AD, Wong TY, Psaty BM, Boerwinkle E, Rotter JI, Siscovick DS, Sladek R, Meigs JB. Association of Levels of Fasting Glucose and Insulin with Rare Variants at the Chromosome 11p11.2-MADD Locus: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Circulation Cardiovascular Genetics 2014, in press.
  5. Meigs JB, Grant RW, Piccolo R, Lopez L, Florez JC, Porneala B, Marceau L, McKinlay JB. Association of African Genetic Ancestry with Fasting Glucose and Hemoglobin A1c Levels in Non-Diabetic Individuals: The Boston Area Community Health (BACH) Prediabetes Study. Diabetologia 2014; in press.

Weight gain after quitting smoking does not negate health benefits

A recent MGH study analysis may have answered a question that has troubled individuals considering stopping smoking: do the health effects of any weight gained after quitting outweigh the known cardiovascular benefits of smoking cessation?

Weight gain after quitting smoking does not negate health benefits

An analysis of data from the Framingham Offspring Study confirms that the health benefits of quitting smoking far exceed any negative effects of weight gained after smoking cessation

Internal Medicine Associates Team 3
15 Parkman Street
Boston, MA 02114-3117

Phone: 617-724-2700
Fax: 617-726-6861