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James B. Meigs MD, MPH is Professor of Medicine at Harvard Medical School, Physician, Division of General Internal Medicine, Massachusetts General Hospital and Co-Director of the MGH Clinical Research Program’s Clinical Effectiveness Research Group.
For over 25 years Dr. Meigs has been a practicing primary care general internist in the MGH Internal Medicine Associates.
Dr. Meigs' research interest for over 20 years has been the cause and prevention of type 2 diabetes and cardiovascular disease. He has authored more than 400 peer-reviewed scientific papers (Thomson Reuters Highly Cited Researcher 2014), supported by multiple NIH and foundation research grants, currently including 2R01 DK078616: Common Genetic Variation and Diabetes Quantitative Traits (PI), U01 DK085526: Multiethnic Study of Type 2 Diabetes Genetics (Co-PI) and K24 DK080140: Epidemiology of Precursors to Type 2 Diabetes (PI). He is a senior scientific leader of several large international type 2 diabetes-related genetic consortia, including MAGIC (Meta Analysis of Glucose and Insulin Consortium), AAGILE (African American Glucose and Insulin genetic Epidemiology) and CHARGE (Cohorts for Heart and Aging Genetic Epidemiology).
Dr. Meigs has mentored over 50 junior clinical research investigators, supported in part by the NIDDK K24 award. In 2009, he was awarded the American Diabetes Association’s Kelly West Award for Outstanding Achievement in Diabetes Epidemiology.
An international research team has identified 60 gene variants that can influence blood levels of hemoglobin A1c, measurements of which are used both to diagnose type 2 diabetes and to monitor blood sugar control. One variant found only in African Americans significantly reduces the accuracy of A1c blood testing, increasing the risk of underdiagnosis in a population known to have a higher risk for the disease.
A recent MGH study analysis may have answered a question that has troubled individuals considering stopping smoking: do the health effects of any weight gained after quitting outweigh the known cardiovascular benefits of smoking cessation?
An analysis of data from the Framingham Offspring Study confirms that the health benefits of quitting smoking far exceed any negative effects of weight gained after smoking cessation
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