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Dr. Nierenberg has over 25 years of experience in conducting clinical trials in mood disorders. He is the Director of the NIMH Bipolar Trials Network and PI of its associated Lithium Moderate Dose Use Study (LiTMUS). He was on the management teams of the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) and the Sequenced Treatment Alternatives to Relieve Depression (STAR*D), which combined included over 8,000 participants and cost over $60 million. Dr. Nierenberg leads as the Principal Investigator on both industry and government funded projects, as well as collaborates with investigators on a national and international level. His major research interests include pharmacologic treatment and course of treatment resistant depression; bipolar depression; phenomenology, longitudinal course, and treatment of mood disorders; and the management of antidepressant-associated adverse events.
The Massachusetts General Hospital Bipolar Clinic and Research Program is launching a 10-site nationwide trial evaluating the real-world advantages and disadvantages of second generation mood stabilizing medications compared to lithium.
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