Find a Doctor

Physician Photo

Joshua L. Roffman, MD

  • Phone: 617-724-1920
Department of Psychiatry
Boston: Massachusetts General Hospital
Medical Education
MD, University of Maryland School of Medicine
Residency, Massachusetts General Hospital
Board Certifications
Psychiatry, American Board of Psychiatry and Neurology
Patient Age Group
Accepting New Patients
Accepting New Patients


Dr. Joshua Roffman is a board certified psychiatrist and investigator in the MGH Schizophrenia Clinical and Research Program (SCRP). He is Assistant Professor of Psychiatry at Harvard Medical School and directs the Brain Genomics Laboratory at MGH.

After graduating with high honors in neuroscience at Amherst College, Dr. Roffman completed his medical training at the University of Maryland, National Institutes of Health, and MGH-McLean Adult Psychiatry Residency Training Program. He was the recipient of early career awards from the Howard Hughes Medical Institute, National Institute of Mental Health (NIMH), and NARSAD/Brain & Behavior Research Foundation among others. His research is currently supported by NIMH, NARSAD, and MQ: Transforming Mental Health, where he was named one of the inaugural MQ Fellows.


Dr. Roffman's research merges brain imaging, genomics, and clinical trials to examine folic acid abnormalities in schizophrenia. His previous work has linked low-functioning genetic variants in the folate metabolic pathway to increased risk for negative symptoms, cognitive impairment, and related alterations in brain activation. Recently completed clinical trials conducted by Dr. Roffman and colleagues at the SCRP have identified modest protective effects of folic acid supplementation, especially among individuals who carry the previously identified genetic variants. Dr. Roffman is currently exploring how variation in folate-related genes, dietary folate intake, and exposure to folic acid during neurodevelopment influence MRI-based markers of schizophrenia vulnerability.

Dr. Roffman is also co-director of the Brain Genomics Superstruct Project, a unique collection of MRI scans and genomic data from >3,500 individuals. Using this resource, Dr. Roffman is examining how genes expressed early in brain development influence MRI markers that are abnormal in schizophrenia. The ultimate goal of this work is to identify biological pathways that may be targeted by folate-based interventions for individuals who are at increased genetic risk for schizophrenia.

Folate and vitamin B12 supplementation reduces disabling schizophrenia symptoms in patients with specific gene variants

Adding the dietary supplements folate and vitamin B12 to treatment with antipsychotic medication improved a core symptom component of schizophrenia in a study of more than 100 patients.

PET scans reveal how psychodynamic therapy for depression may change brain function

MGH investigators have identified changes in the metabolic activity of a key brain region in patients successfully treated for depression with psychodynamic psychotherapy and found evidence that metabolism in a different structure might predict which patients are likely to respond to that form of therapy.

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114

Phone: 617-724-1920
Fax: 617-726-4078

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114

Phone: 617-724-1920
Fax: 617-726-4078

Request a new patient appointment

Call the Massachusetts General Hospital physician referral service at 800-711-4644.

Insurance plans - what you need to know

Mass General accepts most health insurance plans. Find out what you need to know before coming to Mass General.

Directions to Mass General

Driving to Mass General? Get driving directions or locate a parking lot on the hospital's main campus.