Deeper Knowledge and New Treatments

Our goal is to develop a better understanding of mental health, and use that knowledge to create more effective treatments.Learn more about our research focus learn more

Psychiatry Clinical Studies

White matter pathways

Research at the Department of Psychiatry

The MGH Department of Psychiatry’s wide-ranging research portfolio spans clinical and basic research on virtually every major psychiatric disorder. These research initiatives typically began from clinical trials conducted in clinical units, and expanded to observational and mechanistic studies with notable expansions in genetics, neuroimaging, and basic neuroscience.

Over the years, there has been an enormous expansion in the overall volume of research in the Department and associated research funding - with more than $50 million in research programs last year alone -- as well as a gradual shift in funding from pharmaceutical sponsorship to federal and foundation funding.

The model of integrating clinical work and research is evident even in the name of the department’s major programs—the “Depression Clinical and Research Program,” the “Bipolar Clinic and Research Program,” the “Obsessive-Compulsive Disorder Clinic and Research Unit,” and so on. This model of crosstalk between clinical care and science has consistently borne fruit in the form of research advances.

Clinical Trials Network & Institute (CTNI)

At the Clinical Trials Network & Institute, we ensure that our innovative research methods are unmatched in helping sponsors meet their research goals.

Pre-Clinical and Translational Research

Our neuroscience, neuroimaging, and genetic research programs include clinical and translational researchers whose work is informed and motivated by the unmet needs of our patient populations. Our programs include:












#2 in the nation for psychiatric care

U.S. News & World Report ranks Mass General psychiatry second among U.S. hospitals.

Research at Mass General

Discover the largest hospital-based research program in the U.S. and how clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and bring the latest advances to patient care


Proto magazine

Proto magazine stakes its ground on medicine's leading edge, reporting back from the frontiers of research and practice - exploring breakthroughs, dissecting controversies and opening a forum for informed debate.