Psychiatric and Neurodevelopmental Genetics Unit
Center for Human Genetic Research
Massachusetts General Hospital
Richard B. Simches Research Center
185 Cambridge Street
Boston, MA 02114
Alysa E. Doyle PhD is a licensed child and adult clinical psychologist and Assistant Professor of Psychiatry at Harvard Medical School. She holds faculty appointments in the Department of Psychiatry and the Center for Human Genetic Research at Massachusetts General Hospital and is a senior staff member of the Stanley Center for Psychiatric Research at the Broad Institute.
Dr. Doyle’s research lies at the intersection of developmental psychopathology, neuropsychology and psychiatric genetics. Her studies aim to 1) use genes and neuropsychological traits to help disentangle the complex and overlapping etiologies of psychiatric and neurodevelopmental disorders, including ADHD, bipolar disorder, autism spectrum conditions and schizophrenia; 2) determine whether emerging risk variants from the field of psychiatric genetics can aid in the early identification of youth at risk for major adult mental illness; and 3) improve evidence-based assessment practices in child psychiatric populations.
Dr. Doyle has received several awards for her work, including election to Sigma Xi at Williams College, a Dissertation Research Award from the American Psychological Association and a 50th Anniversary Scholars Award from Harvard Medical School. She is also currently a Consulting Editor for the APA journal Neuropsychology. She has been first or co-author on over seventy peer-reviewed publications. Her studies have been funded by the National Institutes of Health as well as private foundations.
Dr. Doyle earned her BA in English and Psychology from Williams College. She received training in child and adult clinical psychology, pediatric neuropsychology and behavioral genetics at the University of Minnesota, where she earned her PhD in 1998. She completed her pre-doctoral internship and post-doctoral fellowship in the Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School before joining the faculty. She was Director of Neuropsychology in the Pediatric Psychopharmacology Unit at MGH for over 10 years.
Current projects include:
- Longitudinal Study of Genetic Influences on Cognition (LOGIC; Role PI)
This project aims to collect DNA and cognitive and psychiatric phenotypes on 3,000 clinically-referred youth enriched for neurocognitive dysfunction. Its goal is to reveal complex trajectories to adult psychiatric illness and provide an evidence base by which to improve early identification and intervention efforts in youth at risk for adult mental illness.
- Genetic Imaging of working memory and interference control in ADHD (Role Co-PI)
This project combines functional and structural neuroimaging data with neurocognitive traits and psychiatric symptoms to explore how compelling ADHD-risk genes impact the brain to produce meaningful variation in behavior.
Kelsey Hudson is a Research Coordinator for the LOGIC study. Kelsey graduated Cum Laude from Vanderbilt University in 2011 with a BA in psychology and a BM in violin performance. Her research interests include the biological bases of neuropsychiatric disorders. Kelsey grew up in Blue Hill, Maine and enjoys exploring the outdoors, finding new restaurants, doing yoga, and rooting for the Boston Celtics.
Erin Hill is a research assistant on the LOGIC study. Erin is currently a doctoral student in Clinical Psychology at Suffolk University. She received her Master’s Degree in Child Development from Tufts University in 2009 and graduated Cum Laude from Carleton College in 2006. Her research interests include peer relationships and the evaluation of pediatric mood disorders.
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