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The mission of PNGU is to identify and characterize the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.
Principal Faculty, Harvard Stem Cell InstituteAssistant Professor, Center for Regenerative MedicinePsychiatric and Neurodevelopmental Genetics UnitCenter for Human Genetic ResearchMassachusetts General HospitalRichard B. Simches Research Center185 Cambridge StreetBoston, MA 02114Phone: 617-643-4371 (o)617-724-4978 (lab)Email: firstname.lastname@example.org
Dr. Sahay is an Assistant Professor at the Center for Regenerative Medicine and the Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School. He is also principal faculty of the Harvard Stem Cell Institute of Harvard University. The focus of Dr. Sahay’s research interests lies in understanding how stem cells in the adult brain may be harnessed to improve cognition and mood and how alterations in neural circuits contribute to the development of psychiatric disorders. The goal of his research program is ultimately to develop new therapeutic strategies for treating cognitive and mood impairments seen in psychiatric disorders such as depression, post-traumatic disorder and during normal aging.Dr. Sahay earned his undergraduate degree at Bennington College and his doctorate in neuroscience from the Johns Hopkins University School of Medicine. Dr. Sahay’s doctoral thesis in the laboratories of Dr. Alex Kolodkin and Dr. David Ginty investigated the role of specific axon guidance cues, secreted semaphorins, in shaping neuronal connectivity in the developing mouse forebrain and in modulation of synaptic transmission in the adult brain. Dr. Sahay carried out postdoctoral research with Dr. Rene Hen at the Center for Neurobiology and Behavior at Columbia University’s School of Physicians and Surgeons. His research demonstrated that selectively increasing adult hippocampal neurogenesis is sufficient to improve pattern separation, a mnemonic process essential for episodic memory formation and potentially, a circuit-based endophenotype in psychiatric illnesses (Sahay et al, Neuron 2011).
See a complete list of Dr. Sahay's publications
Lab manager Sally Levinson, B.S (Ph.D. program in Neuroscience at NYU, 2013-) Tomer Langberg, B.S. (2013- )
Research fellows Nannan Guo, Ph.D. (Fudan University) Kathleen McAvoy, Ph.D. (University of Rochester) Antoine Besnard, Ph.D. (INSERM/CNRS/UPMC, Paris)
Graduate students Tara Raam (Program in Neuroscience) Hugo Vega-Ramirez (Program in Neuroscience)
Undergraduate students Shannen Kim (Harvard) Melissa Boldridge (Harvard) Sekinat Jumai Yusuf (Harvard)
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