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The mission of PNGU is to identify and characterize the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.
Richard B. Simches Research Center185 Cambridge Street Boston, MA 02114 Phone: 617-643-3139 Email: Jscharf@partners.org
Dr. Scharf is a behavioral neurologist and neuropsychiatric geneticist who works at the interface between neurology and psychiatry, employing genetics and clinical research tools to investigate the etiology and pathogenesis of Tourette Syndrome (TS) and related disorders as model neuropsychiatric illnesses. The research lab is focused on genetic and non-genetic factors that predispose individuals to TS and its common co-morbidities, specifically obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD).
Current genetics projects include:
Current clinical research projects include:
We are also launching a clinical research study of electronic health records using novel data-mining methods to identify prenatal and perinatal risk factors for these conditions.
Dr. Scharf is the co-chair of the Tourette Syndrome Association International Consortium for Genetics (TSAICG) Steering Committee, serves on the TSA Scientific Advisory Board, and is principal investigator of the TSAICG multi-center U01 grant from the NINDS. Dr. Scharf is also Director of the Partners Neurology Tic Disorders Clinic and Co-Director of the TAA TS Center of Excellence, which currently sees over 100 new cases a year and provides comprehensive clinical assessments and ongoing management of TS patients referred from local, regional, national, and international sources. These patients also contribute to ongoing clinical and genetic research projects.
See a list of select publications by Dr. Scharf
Cornelia Illmann, Ph.D. Project Director
Lisa OsieckiDatabase Manager
Kelly Yang, BSClinical Research Coordinator
Dongmei Yu, MSStatistical Geneticist
Erica Greenberg, MDChief Resident, Child and Adolescent Psychiatry, Massachusetts General Hospital
Caitlin Gauvin, BSFormer Position: Clinical Research CoordinatorCurrent Position: Medical Student, NYIT
Sarah Weatherall, BAFormer Position: Research Lab TechnicianCurrent Position: Medical Student, Brown University
Jacqueline CraneFormer Position: Laboratory TechnicianCurrent Position:: Pediatrics Resident, UCLA
Janelle AlabisoFormer Position: Clinical Research AssistantCurrent Position: Graduate Student in Psychology, Northeastern University
Gloria GerberFormer Position: Research Lab TechnicianCurrent Position: Medical Student, Robert Wood Johnson Medical School
Lauren BartonFormer Position: Senior Clinical Research AssistantCurrent Position: Clinical Research Coordinator, MGH Stroke Research Center
Lauren McGrath, PhDFormer Position: Postdoctoral FellowCurrent Position: Assistant Professor, Department of Psychology, American University
Paul Lee, M.D.Former Position: Postdoctoral FellowCurrent Position: Staff Psychiatrist, Department of Defense, Honolulu, HI
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