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The mission of PNGU is to identify and characterize the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.
Richard B. Simches Research Center185 Cambridge Street Boston, MA 02114 Phone: 617-643-3139 Email: Jscharf@partners.org
Dr. Scharf is a behavioral neurologist and neuropsychiatric geneticist who works at the interface between neurology and psychiatry, employing genetics and clinical research tools to investigate the etiology and pathogenesis of Tourette Syndrome (TS) and related disorders as model neuropsychiatric illnesses. The research lab is focused on genetic and non-genetic factors that predispose individuals to TS and its common co-morbidities, specifically obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD).
Current genetics projects include:
Current clinical research projects include:
Dr. Scharf is the co-chair of the Tourette Syndrome Association International Consortium for Genetics (TSAICG) Steering Committee, serves on the TSA Scientific Advisory Board, and is principal investigator of the TSAICG multi-center U01 grant from the NINDS. Dr. Scharf is also Co-Director of the Partners Neurology Tic Disorders Clinic, which currently sees over 75 new cases a year and provides comprehensive clinical assessments and ongoing management of TS patients referred from local, regional, national, and international sources. These patients also contribute to ongoing clinical and genetic research projects.
See a list of select publications by Dr. Scharf
Cornelia Illmann, Ph.D. Project Director
Lisa OsieckiDatabase Manager
Caitlin Gauvin, BSClinical Research Coordinator
Dongmei Yu, MSStatistician
Erica Greenberg, MDPediatric Psychiatry Fellow at Massachusetts General Hospital
Sarah Weatherall, BAResearch Lab Technician
Jacqueline CraneFormer Position: Laboratory TechnicianCurrent Position: Medical Student, Tufts University School of Medicine
Janelle AlabisoFormer Position: Clinical Research AssistantCurrent Position: Graduate Student, Boston College
Gloria GerberFormer Position: Research Lab TechnicianCurrent Position: Medical Student, Robert Wood Johnson Medical School
Lauren BartonFormer Position: Senior Clinical Research AssistantCurrent Position: Clinical Research Coordinator, MGH Stroke Research Center
Lauren McGrath, PhDFormer Position: Postdoctoral FellowCurrent Position: Assistant Professor, Department of Psychology, American University
Paul Lee, M.D.Former Position: Postdoctoral FellowCurrent Position: Staff Psychiatrist, Department of Defense, Honolulu, HI
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