Psychiatric & Neurodevelopmental Genetics Unit

The mission of PNGU is to identify and characterize the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.

 

NAME Margaret (Chia-Ying) Wey, Ph.D. Postdoctoral Research Fellow
Psychiatric and Neurodevelopmental Genetics Unit
Center for Human Genetic Research
Massachusetts General Hospital
Richard B. Simches Research Center
185 Cambridge Street, CPZN 6300
Boston, MA 02114
Phone: 617-726-0871
Email: mwey@chgr.mgh.harvard.edu

 

Margaret Wey is a postdoctoral research fellow in the Psychiatric and Neurodevelopmental Genetics Unit at Massachusetts General Hospital. Dr. Wey's primary interests lies within pharmacotherapy, behavioral pharmacology and neuroscience which has been focusing on:

  1. understanding mechanism leading of neurodegenerative disorders (i.e., Parkinson¹s Disease) and psychiatric disorders (i.e., depression, anxiety and compulsive disorders);
  2. develop reliable animal model for neuroscience research;
  3. evaluate genetic risk factors of diseases; and
  4. identify novel therapeutic targets for the treatment of neurological and psychiatric disorders.

Dr. Wey earned her Bachelor¹s degree from China Medical University (Taiwan) in Pharmacy. She earned her Ph.D. in 2012 from the University of Texas Health Science Center at San Antonio in pharmacology with a specialization in neuroscience and biology of aging. She is now expanding her previous expertise in pre-clinical research using behavioral and biochemical techniques into translational and basic clinical investigation of psychiatric disorders.

Dr. Wey has received several awards for her work, including two poster awards and two travel awards. Her work was previously supported by the National Research Service Award (NRSA) from the National Institute of Aging and is currently supported by the Stuart T. Hauser Research Training Program in Biological and Social Psychiatry through Harvard Medical School (T32-NIMH).

Publications:

  1. Wey, M.C.Y., Fernandez E., Martinez P.A. Sullivan, P.S., Goldstein, D., and Strong, R. 2012. Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson¹s Disease. PLoS ONE.
  2. Wey, M.C.Y., Wang, S.S., Sullivan, P.S., Goldstein, D., Fernandez E. and Strong, R. Neuroprotective Effect of Aldehyde Trapping Agent, Hydralazine, in a Parkinson¹s Disease Mouse Model. In preparation.
  3. Bai, X*, Wey, M.C.Y.*, Fernandez E. and Strong, R. Mechanisms of paralysis induced by neuronal overexpression of human A53T alpha-synuclein. In preparation.
  4. Wey, M.C.Y., Lu, X.Y. and Wei Zhang. Attractin mutant mice are sensitive to MPTP-induced Parkinsonism. In preparation.

 

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