Psychiatric & Neurodevelopmental Genetics Unit

The mission of PNGU is to identify and characterize the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.

NAME Chia-Yen Chen, ScD Postdoctoral Research Fellow
Psychiatric and Neurodevelopmental Genetics Unit
Center for Human Genetic Research
Massachusetts General Hospital
Richard B. Simches Research Center
185 Cambridge Street
Boston, MA 02114
Email: cychen@mail.harvard.edu

Chia-Yen Chen, Sc.D. is a post-doctoral research fellow at the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) and the Analytic and Translational Genetics Unit (ATGU) at Massachusetts General Hospital. Dr. Chen is also affiliated with the Broad institute and the Harvard School of Public Health. His primary mentors are Jordan Smoller, M.D., Sc.D., and Benjamin Neale, Ph.D.

Dr. Chen’s research interests lie in genetic epidemiology and population genetics. Dr. Chen has been developing new methods for genetic risk prediction and applying these methods to real data analyses. These methods include improved polygenic prediction models by leveraging genetic ancestry information, genetic risk prediction models based on pleiotropic effects, and prediction models using genetic factors, environmental factors, family history and interactions between risk factors. He also developed methods for ancestry inference with better efficiency than current methods. His recent research focuses on applying these methods in combination with other existing methods to understand the genetic architecture of psychiatric disorders, including post-traumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), and electroencephalography (EEG) phenotypes among schizophrenia and bipolar disorder patients.

Dr. Chen earned a BSc in Life Science in 2004 and a MSc in Epidemiology in 2006 from National Taiwan University. He earned a Sc.M. in Biostatistics in 2012 and a Sc.D. in Epidemiology in 2013 from the Harvard School of Public Health. His doctoral advisor was Alkes L. Price, Ph.D.

Publications

Chia-Yen Chen, Peter Kraft, Alkes L. Price, David J. Hunter, Jiali Han, Jing Cui, Jeffrey A. Sparks, Susan Malspeis, Karen H. Costenbader, Elizabeth W. Karlson. Cumulative genetic risk score from multiple sclerosis is associated with risk of rheumatoid arthritis. In preparation.

Chia-Yen Chen, Jiali Han, David J. Hunter, Peter Kraft, Alkes L. Price. Explicit modeling of genetic ancestry improves polygenic prediction accuracy. Submitted.

Jeffrey A. Sparks*, Chia-Yen Chen*, Xia Jiang, Johan Askling, Linda T. Hiraki, Susan Malspeis, Lars Klareskog, Lars Alfredsson, Karen H. Costenbader, Elizabeth W. Karlson. Performance of risk models for rheumatoid arthritis serologic phenotypes using family history, epidemiologic, and genetic factors. Submitted. (*contributed equally to this work)

Jeffrey A. Sparks, Chia-Yen Chen, Linda T. Hiraki, Susan Malspeis, Karen H. Costenbader, Elizabeth W. Karlson. The Contribution of Environmental Factors and Family History to Risk of Rheumatoid Arthritis and Serologic Phenotypes Among Women in a Longitudinal Cohort Study. Submitted.

Chia-Yen Chen, Samuela Pollack, David J. Hunter, Joel N. Hirschhorn, Peter Kraft, Alkes L. Price. Improved ancestry inference using weights from external reference panels. Bioinformatics 2013; 29: 1399–1406.

Mitchell J. Machiela*, Chia-Yen Chen*, Constance Chen, Stephen J. Chanock, David J. Hunter, Peter Kraft. Evaluation of polygenic risk scores for predicting breast and prostate cancer risk. Genetic Epidemiology 2011; 35: 506-14. (*contributed equally to this work)