Join the PNGU team
Job Title: Postdoctoral Research Fellow in Molecular Neuroscience
The Petryshen laboratory within the Psychiatric and Neurodevelopmental Genetics Unit in the MGH Center for Human Genetic Research is seeking a motivated and highly trained postdoctoral fellow to conduct neuroscience research to study psychiatric disorder risk genes in rodent models. Studies will focus on developing technology to selectively modulate in vitro and in vivo transcription of a bipolar disorder risk gene in cellular and mouse models to examine gene function in disease-related neural processes and behavior. The position entails using expert scientific knowledge and technical expertise in molecular neuroscience to design and execute experiments including developing and validating transcription activator-like effectors (TALEs) to up- and down-regulate gene expression in an isoform-specific manner in cell culture and mouse brain to study the effect on neural function and behavior.
The fellow will work in a world-class training environment consisting of clinical and basic research scientists, statistical geneticists, and computational biologists who are leaders in the development of genetic analysis methods, human genetic studies of psychiatric and other multifactorial disorders, and animal and cellular model studies of genetic diseases. The fellow will have joint appointments at MGH and Harvard Medical School.
The projected start date is October 1, 2013. A two-year commitment is expected, with possible extension dependent upon grant funding.
- Develop TALE technology to bi-directionally modulate transcription of alternative transcripts of psychiatric risk genes in vitro and in vivo in neuronal cultures and mouse brain.
- Evaluate effects of gene perturbation in neuronal cultures and mouse brain including transcriptome analysis, neuronal morphology and function, and behavioral analysis to determine the disease-relevant function of psychiatric risk genes.
- Present results in seminars and at conferences, generate data for grant applications, and prepare scientific publications.
- PhD in Molecular Neuroscience or a related field and at least 4 years experience in a rodent neuroscience research laboratory.
- Demonstrated ability to design and conduct research with minimal instruction. Strong initiative to learn and develop new techniques, and resourceful in troubleshooting technical challenges.
- Strong training in molecular biology and neurobiology principles and methods including DNA/RNA/protein isolation and measurement (PCR, qRT-PCR, in situ hybridization, microarray transcript profiling, RNA-seq, Western blotting, immunohistochemistry), sequencing, molecular cloning, viral vector construction, culture and transfection of cell lines and primary neurons, antibody production, and fluorescent, confocal, and two-photon microscopy.
- Experience with rodent neuroscience methods including brain stereotaxic surgery, viral gene expression, brain tissue fixation, sectioning, and microscopy, examination of neuronal and synaptic morphology and function, and behavioral analyses. Familiarity with psychiatric models and neuronal and brain slice electrophysiology is desirable.
- Knowledge of scientific and bioinformatics databases for characterization of gene structure, designing targeting constructs, brain transcript and protein expression, and sequence analysis.
- Highly motivated to work independently and within a team on multiple projects simultaneously in a multi-disciplinary fast-paced environment.
Interested candidates should email their CV and names of 3 references to Dr. Tracey Petryshen: email@example.com
Job Title: Clinical Research Coordinator I
Location: MGH Main Campus - Boston
Std Hrs/Wk: 40.00
Full/Part Time: Full-time
We are seeking two BA or MA-level clinical research coordinators (CRCs) to work on a high-impact project studying the genetic bases of child and adult neuropsychiatric disorders. The start date for one position is March 2013, the start date for the second position is June 2013. Both positions require a 2-year commitment and are well-suited to individuals planning to attend doctoral programs in clinical psychology or medical school. Responsibilities include recruiting and interacting with study subjects, learning and administering a small number of neuropsychological tests, entering data, collecting DNA via saliva samples, and assisting with IRB approvals, grant applications, literature reviews and slide and manuscript preparations.
Competitive candidates should have:
- excellent organizational skills and attention to detail
- excellent verbal and written communication skills
- the ability to work both as part of a team and independently
- psychology major and strong GPA
- research experience
- prior experience working with children/adolescents
- interest in genetics, neuroscience and/or the biological basis of psychopathology
- knowledge of Excel and Power Point
The Psychiatric and Neurodevelopmental Genetics Unit and the Analytic and Translational Genetics Unit in the MGH Center for Human Genetic Research and the Broad Institute of MIT and Harvard have an immediate opening for a postdoctoral position for methods development and genetic, statistical and bioinformatic analyses of large-scale studies of disease susceptibility, transcriptomics, and epigenetics. Ongoing studies include GWAS and sequencing analyses of psychotic, mood, anxiety, and developmental disorders as well as neuroimaging phenotypes related to these disorders.
Close supervision and intensive training will be provided by a team of collegial experts in neuropsychiatric genetics, statistical genetics, bioinformatics, computational biology, and genetic epidemiology. We seek a highly motivated and dedicated MD or PhD in genetics, bioinformatics or statistical genetics with excellent quantitative skills, proven ability to work well in a collaborative environment, fluency with all modes of communication in English, and strong writing skills. The successful applicant will have strong training in statistics or biostatistics, data mining, and genetic analysis as well as experience with database management and computer programming.
To apply, please send a single email containing your CV, a short statement describing your qualifications for this position, and contact information for three professional references to Dr. Jordan W. Smoller at firstname.lastname@example.org or Benjamin Neale at email@example.com.
- Job Title: Clinical Research Program/Project Manager
Overview Statement: The Psychiatric and Neurodevelopmental Genetics Unit (PNGU) of the Center for Human Genetic Research is seeking a Program Manager to coordinate and oversee clinical and translational research projects on the genetics of psychiatric disorders specifically for the Director as well as manage tasks related to the running of the unit.
Scope of Position: PNGU is a multidisciplinary research program devoted to understanding genetic and environmental contributions to childhood and adult psychiatric disorders. This position offers a unique and exciting opportunity to lead programs that are at the cutting edge of genetic research in a time of great transition in the field. Reporting to and working closely with the Director, the Program Manager will have responsibility for coordinating human subjects research and operational activities of the Director’s program including range of genetic and clinical research studies of neuropsychiatric disorders. He or she will play a key role in guiding the research activities of the program. He or she will also have primary responsibility for maintaining and managing human subjects’ approvals, study compliance, project timelines and documentation, coordinating research meetings, coordinating multisite research projects, creating and overseeing standard operating procedures for the research program and the unit, and training and supervising research assistants. He or she will also provide management support to the Principal Investigator in his various roles including but not limited to in the Harvard Clinical and Translational Science Center Translational Genetics Education Program, as the Science Director of the Harvard Center on the Developing Child, and as the Chair of the 2013 World Congress of Psychiatric Genetics.
The ideal candidate will possess the ability to:
- Provide leadership skills necessary to create effectively functioning operations.
- Work productively and collaboratively with a wide variety of people, including clinical investigators, clinical and administrative support staff, colleagues and supervisors.
- Understand and provide leadership to staff regarding the issues and regulations important to translational and human subjects research.
- Personal skills: must be responsible and conscientious; have strong computer skills; outstanding interpersonal skills and sensitivity to human subjects issues; excellent communication skills (both written and oral), ability to work independently with minimal supervision; strong time management & organizational skills; and ability to handle multiple projects simultaneously.
- Masters degree or equivalent in health-related field
- Experience in clinical research area, preferably mental health or genetic research.
- Management experience
Interested applicants should email a resume and cover letter to Alison Hoffnagle at firstname.lastname@example.org. Candidates invited to interview for the position should be prepared to provide a writing sample and two letters of recommendation.
Competitive salary that varies depending on experience, competitive benefits package.
Interested applicants should email a resume and cover letter to Dr. Alysa Doyle at email@example.com. Candidates invited to interview for the position should be prepared to provide a transcript and two letters of recommendation.