The Post-Traumatic Stress Disorder (PTSD) Research Laboratory at Massachusetts General Hospital conducts federally funded, psychophysiological and neuroimaging research into post-traumatic stress disorder.

Our current major focus is whether medications administered at the time of traumatic memory reactivation can weaken the distressing emotional component of these memories through reconsolidation blockade, which is a potential novel treatment for PTSD. This work is conducted both at Mass General and at subcontract sites internationally. Ancillary work in this area includes preclinical studies with rats and normal humans. We are also conducting an ongoing, large-scale, psychobiological investigation of a national sample of monozygotic twins discordant for combat exposure in Vietnam.

Another major research area is maternal adaptation to the landmark event of childbirth. We are studying the psychological and biological mechanisms involved in mothers’ adaptation following a potentially traumatic childbirth experience. We are conducting a longitudinal and prospective study on pregnant women to gain insight into the various psychological reactions to childbirth, including postpartum depression, anxiety and the overlooked traumatic stress response.

We are also interested in whether acute neurological soft signs following traumatic brain injury can predict the subsequent development of postconcussive, PTSD and other psychopathological symptoms. Subject referrals are welcome.

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PTSD Research Laboratory

Charlestown Navy Yard
120 2nd Ave.
Charlestown, MA 02129
Maps & directions

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Meet Our Staff
Our researchers are engaged in an ongoing series of studies related to both causes and preventative measures for PTSD.
Research Projects
Current research includes assessment, pathophysiology, prevention and treatment of PTSD.

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