Clinical Research

Depression Treatment Studies: At the Depression Clinical and Research Program, the following treatment studies are currently under way, and seeking participants.

The DCRP is currently conducting cutting edge research in the area of depression, with a focus on testing novel antidepressant treatments and on developing new tools to understand the biological changes that occur in this condition.

If any of these studies interest you, please call us at 1-877-552-5837.

TREATMENT STUDIES

Smoking Cessation and Relapse Prevention:
The purpose of the study is to test the effectiveness of an investigational drug for the prevention of relapse to smoking in men and women who have recently quit smoking. READ MORE

A Study of Riluzole When Taken with Sertraline for Major Depressive Disorder:
The purpose of this study is to test whether adding the medication riluzole to Selective Serotonin Reuptake inhibitor (SSRIs) antidepressants for the treatment of depression enhances the efficacy of the SSRIs. READ MORE

A Study to Test the Safety and Effectiveness of Ziprasidone with an Anti- Depressant, Escitalopram, for Patients with Major Depressive Disorder:
A medication study that is geared towards individuals who have already tried at least one anti depressant, but not found relief from depressive symptoms. The purpose of this study is to examine the effectiveness and safety of Ziprasidone when it is taken in addition to an antidepressant, in this case Lexapro. READ MORE

Exploring biomarkers for depression:
This study looks at the biomarkers in voice, physiological, movement and brain imaging signals of patients with depression to investigate what types of biological signals identify and predict depression. READ MORE

Predicting Responses to Antidepressant Medications:
This study is looking for ways to tell in advance which medication will work best to help those with depression get better. Click the link below for more information about this research study: http://embarc.utsouthwestern.edu/mgh.html.

College Suicide Prevention Study:
This study gives researchers a unique look into the minds of college-aged students (18-23) to assess for depression and suicidal ideation. This study consists of psychological screenings at colleges around the country. Students are asked to fill out packets of psychological questionnaires. Based on their answers they may be eligible for free therapy sessions with our clinicians at the Depression Clinic, or eligible to receive compensation for filling out online questionnaires.
Please note: This study is only open for targeted populations.

Dialectical Behavior Therapy (DBT) for Patients with Depression and Suicidal Thoughts and Behaviors:
This is a study to see if a type of group therapy that teaches Dialectical Behavior Therapy (DBT) skills is helpful in treating symptoms of depression and suicidal thoughts and behaviors. READ MORE

Mindfulness-Based Cognitive Therapy for Pain and Comorbid Unipolar Depression:
The purpose of this research study is to evaluate the effectiveness of a group program that combines cognitive therapy with mindfulness meditation for people who have chronic pain and depressive symptoms. The study also looks at how the brain, immune system, and hormone levels are altered by participation in this program. READ MORE
Please note: This study is only open for targeted populations.

Transcranial Laser Therapy for Depression:
In this pilot study, we are testing whether Transcranial Laser Therapy (TLT) can help people’s depression. TLT involves a non-invasive and invisible beam of light that is briefly delivered to the forehead. TLT increases certain kinds of brain activity that may be useful for depression treatment.READ MORE

A Study of Iloperidone to Treat Anger and Irritability When Taken with an Antidepressant:
This study is investigating whether adding the medication Iloperidone to Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants will help treat symptoms of anger and irritability.

A Study of Lurasidone to Treat Depression with Mixed Features:
This study is testing whether the medication Lurasidone is safe and effective in treating depression with mixed features (periods of feeling sad or down along with periods with an elevated mood).

Ketamine Infusion for Treatment-resistant Major Depressive Disorder with Suicidal Ideation:
The purpose of this study is to test whether repeated use of intravenous ketamine, in addition to ongoing antidepressant treatment, improves symptoms of depression and suicidal ideation in patients who have not improved adequately on different antidepressant medication.

Help for sadness and excessive drinking in college students:
In this study, we are investigating new and effective therapy treatments for college students who experience depressive symptoms and drink excessively. We are comparing two different treatment courses, both of which consist of 8 sessions with a counselor and are provided at no cost. Participants will be compensated for their time.
Please note: This study is only open for targeted populations.

Well-being Therapy + Stimulant Medication for Depression:
The purpose of this research study is to see if using a combination of Well-being Therapy (WBT) and an FDA-approved stimulant medication helps improve symptoms of depression. This research study is specifically for individuals who are currently taking an antidepressant medication that has not worked for them.

NON-TREATMENT STUDIES

Cortical GABA (Gamma-AminoButyric Acid) in MDD (Major Depressive Disorder)/Insomnia Study:
The purpose of this study is to understand the neurochemical mechanisms underlying insomnia in individuals with and without depression. We will assess a group with no insomnia and no depression, a group with insomnia without depression, a group with depression without insomnia and a group with depression and insomnia. In this way, we hope to determine whether GABA abnormalities in MDD are related to insomnia or the mood state. READ MORE

Altropane and Raclopride PET Studies:
These studies use PET scans, a type of brain imaging, to explore how certain brain chemicals work in people who have depression.

Visual Memory and Object Recognition:
The purpose of this study is to understand how people recognize and remember things that they encounter in their everyday environments. Participants will complete a series of basic tasks that involve viewing and rating pictures displayed on a computer screen and/or responding to words or phrases.

Responses to Reward and Punishment in those with Depression:
This study explores how people with depression differ in their responses to reward and punishment compared to those without depression. This study is completed at one visit, and participants will do two computer tasks and complete questionnaires. READ MORE

National Network of Depression Centers’ Clinical Care Registry:
In this research study, we are helping to form the first-ever national database on depression symptoms and treatment outcomes. Both research and clinical patients can take part in this study, by filling out questionnaires on their mood during their visits to the DCRP.

Alcohol Consumption, Rewards, and Emotions among College Students:
The purpose of this research study is to learn more about the relationships among alcohol consumption and responses to emotions and rewards among undergraduate college students who are not depressed. The study is completed in one visit and participants will be compensated for their time.
Please note: This study is only open for targeted populations.