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Division of Pulmonary and Critical Care Medicine
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Since arriving at MGH in 1999 I have had the privilege of training in internal medicine and cardiology, teaching as a chief resident and as a cardiology attending, providing clinical care to patients with a broad range of cardiovascular diseases, and conducting research. As an investigator at MGH I have published over 50 manuscripts in fields ranging from the evaluation of novel therapies for heart failure to mechanisms of exercise intolerance in cardiovascular disease and metabolic response patterns to exercise. I am particularly interested in the role of the lung circulation in mediating exercise intolerance in patients with heart failure. Our team of investigators is also interested in understanding the molecular mechanisms of exercise adaptation through mass spectrometry-based metabolic profiling in collaboration with the Broad Institute and Dr. Robert Gerszten. My clinical interests parallel my research interests and focus on improving cardiac performance in patients with a variety of cardiovascular diseases. As a staff member in the recently established Cardiac Performance Program I look forward to offering state of the art cardiopulmonary exercise testing to a broad spectrum of individuals- from patients with heart failure to athletes- in an effort to further understand and improve cardiac performance. As medical Director of Mechanical CIrculatory Support and the Cardiology Intensive Care Unit I also have a strong interest in treatment of advanced heart failure and other critical illnesses
Please see Pubmed for a complete list
Lewis GD, Shah R, Shahzad K, et al. Sildenafil Improves Exercise Capacity and Quality of Life in Patients with Systolic Heart Failure and Secondary Pulmonary Hypertension. Circulation. 2007.116:1555-1562.
Lewis GD, Gona P, Benjamin EJ, et al. Exercise Blood Pressure and the Risk of Incident Cardiovascular Disease: The Framingham Heart Study. Am J Cardiol 2008, Jun 1;101(11):1614-20
Lewis GD, Shah RV, Systrom DM, et al. Determinants of Ventilatiory Efficiency in Heart Failure. Circulation Heart Failure, 2008; 1: 227-233
Lewis GD, Farrell L, Wood MJ, et al. Metabolic Signatures of Exercise in Human Plasma. Science Translational Medicine. 2010;2(33)
Using a system that analyzes blood samples with unprecedented detail, a team led by MGH researchers has developed the first "chemical snapshot" of the metabolic effects of exercise.
Study of 'planned' heart attacks identifies markers that could improve treatment, save lives.
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