Pulmonary and Critical Care Medicine

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Charles Hales, MD

Major interest in pulmonary hypertension and its treatment with heparin derivatives we have produced which are weakly anticoagulant but strongly antiproliferative for smooth muscle cells, pulmonary emboli detection and smoke inhaltion from fires.

Research Interests:

Heparin on Hypoxic Pulmonary Hypertension and Remodeling
Combined Smoke Inhalation Injury and Burn Injury
Pulmonary Emboli
Ventilator-Induced Lung Injury

Charles A. Hales MD honored with AHA award

MGH Hotline 010909 Charles A. Hales, MD, chief of the MGH Pulmonary and Critical Care Unit, has received the 2008 Distinguished Achievement Award from the American Heart Association's Cardiopulmonary, Perioperative and Critical Care Council.

Longas MO, Garg HG, Trinke-Pereira JM, Hales CA. Heparin antiproliferative activity on bovine pulmonary artery smooth muscle cells requires both N-acetylation and N-sulfonation. Carbohydrate Research 2003;338:251-256.

Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA. Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med 2003;167:1627-1632.

Cindhuchao N, Quinn DA, Garg HG, Hales CA. Heparin inhibits SMC growth in the presence of human and fetal bovine serum. Biochem and Biophys Res Communic 2003;302:84-88.

Quinn DA, Hales CA, Syrkina O, Volokhov A, Moufarrej RK. Combined smoke inhalation and scald burn in the rat. J Burn Care and Rehabil 2003;24:208-216.

Garg HG, Yu L, Hales CA, Toida T, Islam T, Linhardt RJ. Sulfation patterns in heparin and heparin sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cell. Biochem and Biophys Acta 2003;225-231.

Mascarenhas MM, Day RM, Ochoa CD, Choi WI, Yu L, Ouyang B, Garg HG, Hales CA, Quinn DA. Low molecular weight hyaluronan from stretched lung enhances IL-8 expression. Am J Resp Cell Mol Biol 2004;30:51-60.

Jafari B, Ouyang B, Li LF, Hales CA, Quinn DA. Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells. Respirology 2004 9:43-53.

PubMed Publications

Charles Hale Lab

55 Fruit Street
BUL 128
Boston, MA 02114

Phone: 617-726-1766
Fax: 617-726-6878