Sarcoma Program

The Sarcoma Program in the Department of Radiation Oncology uses state-of-the-art radiation therapies to treat soft tissue and bone tumors, both malignant and benign.


Mass General’s Center for Sarcoma & Connective Tissue Oncology, part of the Cancer Center, is one of the largest and most specialized centers to treat malignant and benign tumors. Here, our radiation oncologists collaborate with your entire treatment team, which may include medical oncologists, surgical oncologists, orthopaedic oncologists, diagnostic and interventional radiologists and pathologists.

Working closely with these specialists, our practitioners integrate radiation therapy into your treatment plan, which also may involve chemotherapy and/or surgery. Our oncologists' expertise includes using the most advanced techniques and innovative technologies, such as proton therapy, a treatment available at few U.S. hospitals.

Our team treats the complete spectrum of sarcomas and benign tumors, such as:

Improving Care Through Innovation

Mass General's Herman Suit, MD, PhD, helped pioneer the treatment of soft tissue sarcomas with radiation therapy. Today our radiation oncologists continue this rich tradition of innovation, performing groundbreaking research and applying their advances to improve quality of life for our patients.

Many breakthroughs in treating sarcomas were introduced at Mass General, such as:

  • Proton beam therapy: Our oncologists were among the first in the country to treat sarcomas with proton beam therapy. This innovative treatment protects organs and tissues beyond the tumor region when compared with conventional photon therapy. Intensity modulated proton therapy (IMPT) is now available to provide the most conformal radiation doses to the tumor with maximal sparing of normal tissue.
  • Image guided radiation therapy (IGRT): Mass General was among the first institutions to use this technology on a routine basis to improve the accuracy of daily radiation therapy
  • CT-based radiation therapy treatment planning
  • Dural applicator plaque for radiation therapy of spine sarcoma: Our team developed this brachytherapy technique (internal radiotherapy using implants), which delivers high doses of radiation to tumor cells while protecting the highly sensitive spinal cord from radiation exposure
  • Preservation of limbs and tissue: Using various radiation therapies, sometimes in conjunction with surgery, we have developed techniques that enable more patients to retain their limbs and their limb function. Also, we integrate radiation therapy with surgery and/or chemotherapy to treat tumors in bones that cannot be removed, such as the spine and pelvis

We also offer the full range of 3D conformal radiation therapy techniques including intensity modulated proton therapy (IMPT), intensity modulated photon therapy (IMRT), stereotactic body radiation therapy (SBRT), image guided radiation therapy (IGRT), therapies,low- and high-dose rate brachytherapy, pre-operative radiation treatment of sarcomas and intraoperative radiation therapy (IORT), a technique in which patients receive radiotherapy during surgery.

Meet the Team

Every step of your radiation therapy is managed by an experienced radiation oncologist who has dedicated his or her career to treating patients with sarcomas. Our physicians are some of the leading practitioners in the field:

  • Thomas DeLaney, MD, program chief and medical director of the Francis H. Burr Proton Therapy Center, is a world-renowned authority on the treatment of bone and soft-tissue sarcomas. Dr. DeLaney has introduced many breakthrough technologies, runs innovative clinical trials aimed at improving patient outcomes and collaborates with leading medical and surgical oncologists to develop new treatment methods. He has published extensively on the treatment of sarcomas.
  • Norbert Liebsch, MD, PhD, is an expert in using proton therapy to treat complicated sarcomas of the cranial base and spine. An accomplished researcher and educator, Dr. Liebsch has practiced radiation oncology for more than 25 years
  • Yen-Lin Chen, MD, specializes in using advanced radiation methods, including proton therapy, to treat sarcomas, connective-tissue tumors and benign conditions in young adults and adults

Patient Education

We encourage you to ask us about any step in the treatment process, from understanding the safety of your therapy to managing side effects. The answers to many frequently asked questions also appear in Your Guide to Radiation Therapy (PDF).

Clinical Trials

Massachusetts General Hospital invites patients and the community to participate in innovative clinical trials and research studies.

Search open clinical trials.


Contact Us

Clark Center for Radiation Oncology

Vida E & Arthur L. Goldstein Lunder Building

55 Fruit StreetLunder Building LL3 Boston, MA 02114
  • Near Public Transit
  • Accessible
  • Phone: 617-726- 8651
  • Fax: 857-238-6377
  • Email Us

Francis H. Burr Proton Therapy Center
30 Fruit Street
Boston, MA 02114
Phone: 617-726-0923 (Proton Inquiry Line: 617-724-1680)
Fax: 617-726-6498

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