Breast Program
The Breast Program at Massachusetts General Hospital is staffed by leading radiation-therapy experts who provide compassionate, state-of-the-art care to patients with breast cancer.
Our Approach
Each year, our radiation oncologists treat thousands of women and men with every type of breast cancer, including recurring forms of the disease.
Breaking New Ground in Breast Cancer Treatment
Founded nearly 40 years ago, our program is one of the first—and most innovative—breast radiation oncology programs in the United States. We work closely with the Mass General Cancer Center, to develop and investigate advanced therapies and technologies used around the world to make treatment more effective and improve the quality of patients' lives.
Our breakthroughs in radiation therapy for breast cancer include:
- Partial breast irradiation (PBI): For selected patients with early-stage cancer, we use this noninvasive technique to deliver radiation precisely to the area from which the tumor was removed. As a result, we can reduce treatment length from months to a week, potentially reducing side effects
- Heart protection: To eliminate or decrease the heart's exposure to radiation, we use an advanced method that combines exceptional precision with a breath-holding technique for patients with cancer of the left breast and certain cardiac characteristics
- Lymphedema program: After some treatments, such as axillary lymph node dissection and/or axillary radiation, a patient's arm may swell, causing cellulitis. Difficult-to-treat when advanced, lymphedema also can be unattractive, profoundly affecting emotional and psychological well-being. We initiated a screening program to detect very early signs and designed a trial for early intervention. This program includes laser-perometer measurements before and after treatment and twice annually during follow up, as well as access to physical therapists who specialize in lymphedema
- Proton beam therapy: We are planning clinical trials for selected patients to determine the effectiveness of administering radiation to the left breast or chest wall with proton therapy. This approach may eliminate the heart's exposure to radiation
Dedicated & Accomplished Specialists
Every step of your treatment is managed by an experienced radiation oncologist who has dedicated his or her career to studying and treating breast cancer.
Our staff includes leading practitioners in the field of breast radiation oncology:
- Alphonse Taghian, MD, PhD, program chief, has treated thousands of patients with breast cancer over the last 20 years. Dr. Taghian is a leader in partial breast irradiation with 3D conformal techniques, founded the service’s lymphedema program and consults with physicians nationwide on complicated cases
- Shannon MacDonald, MD, specializes in breast cancer and is conducting a leading-edge investigation into using treating the left wall of the chest with proton therapy
Personalized & Comprehensive Care
In the highly specialized Gillette Center for Breast Cancer, our radiation oncologists work side-by-side with your entire cancer treatment team. These world-class breast cancer specialists may include medical oncologists, surgical oncologists, radiologists, pathologists, physical therapists, social workers and genetic counselors. Our cross-specialty approach enables us to provide comprehensive care tailored to your needs.
What to Expect
We encourage you to ask us about any step in the treatment process. The answers to many frequently asked questions also appear in Your Guide to Radiation Therapy (PDF).
Breast Cancer in Men
Breast cancer in men is a rare condition in which certain cells in the breast become abnormal and multiply without control to form a tumor.
Lymphedema Following a Mastectomy
When the normal drainage pattern in the lymph nodes is disturbed or damaged (such as during radiation or during surgery to remove lymph nodes), this may cause an abnormal collection of fluid that causes the arm to swell.
HOPES Program
The HOPES Program provides free wellness services, plus education and support workshops for patients with cancer, their families and their friends. Our services focus on helping you take care of your whole self – mind, body and spirit.
Your Guide to Radiation Therapy (PDF)
Read our patient information guide to learn more about the different types of radiation treatments and what patients can expect.
The following related clinical trials and research studies are currently seeking participants at Massachusetts General Hospital. Search for clinical trials and studies in another area of interest.
HOPES Program
The HOPES Program provides free wellness services, plus education and support workshops for patients with cancer, their families and their friends. Our services focus on helping you take care of your whole self – mind, body and spirit.
Your Guide to Radiation Therapy (PDF)
Read our patient information guide to learn more about the different types of radiation treatments and what patients can expect.
James and Ruth Clark Center for Radiation Oncology
Cox BuildingLower Level
100 Blossom Street
Boston, MA 02114
Phone: 617-726-8650
Fax: 617-724-2019
Email: InformationRadOnc@Partners.org
Public Transportation Access: yes James and Ruth Clark Center for Radiation Oncology Francis H. Burr Proton Therapy Center
Disabled Access: yes
Cox Building, Lower Level
100 Blossom Street
Boston, MA 02114
Telephone: 617-726-8650
Fax: 617-724-2019
e-mail: InformationRadOnc@partners.org
30 Fruit Street
Boston, MA 02114
Telephone: 617-726-0923 or 617-724-1680
Fax: 617-726-6498
e-mail: InformationRadOnc@partners.org


