BiographyMy research and clinical interests are in Neuro and Cardiac radiology. My research is focused on development and clinical applications of ultra-high resolution CT. In my lab, we are developing and testing a prototype CT system based on flat-panel X-ray detectors with a resolution of 150 microns. This system, when fully developed, has the potential to open a new window on human anatomy and physiology by enabling, in a single scanner, dynamic imaging of temporally evolving processes, image-guided interventions, and high-resolution computed tomography. This system has already resulted in several significant clinical results. For example, we have demonstrated that the trabecular structure of the bone in Anorexia Nervosa is significantly altered even when the conventional metrics for measuring it (e.g., DEXA) are normal. Furthermore, this change is irreversible and results in fundamentally altered biomechanics of the bone leading to significantly increased fracture risk in adult life, even after the disease has been fully treated. For dynamic CT imaging, we have developed a new technique and demonstrated its feasibility in an animal model of aneurysms. Algorithms for efficient and accurate reconstruction of dynamic data are under development. The paradigm of volumetric CT using a large area detector also enables image-guided interventions in the same scanner. To this end, we are developing a new genre of low-cost, X-ray transparent, disposable robots that can operate inside the bore of the scanner
PublicationsElizabeth A, Lawson EA, Miller KK, Bredella MA, Phan C, Misra M, Meenaghan E, Rosenblum L, Donoho D, Gupta R, Klibanski K. Hormone Predictors of Abnormal Bone Microarchitecture In Women with Anorexia Nervosa. Bone, in press
Sangwaiya MJ, Saini S, Gupta R, Yoo AJ, Stout M, Dreyer K, Kalra M. A "different level" of Radiology Reporting: Discrepancies in MR of the Spine. The Journal of the American College of Radiology, in press
Torriani M, Gupta R, Donahue DM. Sonographically guided anesthetic injection of anterior scalene muscle for investigation of neurogenic thoracic outlet syndrome. Skeletal Radiol. 2009; 38(11):1083-7. PMID: 19440705
Cheung AC, Bredella MA, Al Khalaf M, Grasruck M, Leidecker C, Gupta R. Reproducibility of trabecular structure analysis using flat-panel volume computed tomography. Skeletal Radiol. 2009; 38(10):1003-8. PMID: 19430779
Mitha AP, Reichardt B, Grasruck M, Macklin E, Bartling S, Leidecker C, Schmidt B, Flohr T, Brady TJ, Ogilvy CS, Gupta R. Dynamic imaging of a model of intracranial saccular aneurysms using ultra-high-resolution flat-panel volumetric computed tomography. Laboratory investigation. J Neurosurg. 2009; 111(5):947-57.PMID: 19374491
Weinand C, Gupta R, Weinberg E, Madisch I, Neville CM, Jupiter JB, Vacanti JP. Toward regenerating a human thumb in situ.Tissue Eng Part A. 2009; 15(9):2605-15. PMID: 19199577
Reichardt B, Sarwar A, Bartling SH, Cheung A, Grasruck M, Leidecker C, Bredella MA, Brady TJ, Gupta R. Musculoskeletal applications of flat-panel volume CT. Skeletal Radiol. 2008; 37(12):1069-76. PMID: 18443787
MGH Hotline: 12/05/08
MGH Hotline 10.08.10 Rajiv Gupta, MD, PhD, director of the MGH Ultra-High-Resolution Volume CT Lab, has been appointed the MGH site miner for the Center for Integration of Medicine and Innovative Technology (CIMIT).
Some answers as to how the MGH's Egyptian mummy Padihershef lived and died are now being explored through a conservation project - which included a full body X-ray and CT scan.