Jason P. Holland, D.Phil

Jason P. Holland, D.Phil

Instructor in Radiology, HMS
Assistant Chemist, MGH

Email:   holland.jason@mgh.harvard.edu
Phone:   1-617-726-6107


Biography

Jason P. Holland read chemistry (MChem, Hons) at the University of York, United Kingdom, in 2004. He completed his doctoral studies (D.Phil) in Inorganic and Computational Chemistry under the joint supervision of Prof. Jennifer C. Green and Prof. Jonathan R. Dilworth at the University of Oxford, United Kingdom, in 2008.

After completing his doctoral studies, he moved to New York City to work as a Post-Doctoral Scholar with Prof. Jason S. Lewis in the Department of Radiology, Memorial Sloan-Kettering Cancer Center from 2008 to 2010. Jason was awarded an ETH Fellowship in 2010 and worked as a senior research fellow at ETH Zurich until Sept 2012 when he was appointed to faculty at Massachusetts General Hospital as Assistant in Chemistry, and Instructor in Radiology at Harvard Medical School.

Jason’s work and area of expertise is highly diverse and interdisciplinary, spanning all aspects in organic synthesis of ligands and coordination chemistry, computation chemistry using Density Functional Theory methods, cyclotron targetry, separation science, radiochemistry with various nuclides (11C, 18F, 64Cu, 67/68Ga, 86Y, 89Zr, 90Nb, 111In, 124/131I and  225Ac etc) , prtotein conjugation chemistry, radiotracer design and evaluation both in vitro and in vivo using animal models of human cancers for nuclear imaging studies with positron emission tomography [PET], single-photon emission computed tomography [SPECT], magnetic resonance imaging [MRI], computed tomography [CT], bioluminescence, fluorescence mediated tomography [FMT] and Cerenkov luminescence imaging [CLI], as well as therapeutic studies with α- and b- particle emitting radiotherapeutic agents.

Jason’s work has been reported in over 50 peer-reviewed publications and he has been awarded numerous prizes and honors including the Journal of Nuclear Medicine’s Editor’s Choice Award 2011, for the best basic science article. He is a regular reviewer for many of the top journals in chemistry and nuclear medicine and current serves on the editorial board of several journals including the Journal of Nuclear Medicine and the American Journal of Nuclear Medicine and Molecular Imaging.

To see a list of selected publications, visit Jason's profile on Harvard Catalyst

Education

  • MChem (Hons) in Chemistry, 2004, University of York, York, United Kingdom
  • D.Phil in Chemistry, 2008, University of Oxford, Oxford, York, United Kingdom

Professional Positions

  • Post-Doctoral Scholar, 2008-2010, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, United States of America
  • ETH Fellow, 2010-2012, Institute for Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
  • Assistant in Chemistry, 2012-Present, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America
  • Instructor in Radiology, 2012-Present, Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America

Research Projects