Hongmei Mou, PhD
Hongmei was born in a small town in the south of China. In 1993, she received a B.S. degree in Biochemistry at Beijing Normal University, and in 1996 an M.S. degree in Genetics at the Institute of Genetics, Chinese Academy of Sciences. In 2002, she earned her Ph.D. in Biochemistry and Molecular Biology at the University of New Hampshire where she studied the regulation of photoresponse recovery and desensitization to light. She show that the regulation was mediated through the protein regulators PDE-gamma and PDE-delta. In 2003, as a postdoctoral fellow at Harvard Medical School, she studied innate immunity and pathogen-induced airway inflammation. Her work showed that p73 acts as a key negative regulator of the inflammatory program triggered by TLRs-related responses in ciliated epithelia. This is a new pathway and mechanism to regulate the inflammatory response and provides a potential target for airway disease due to hyper-inflammation.
Currently, she wishes to apply au understanding of mosue endoderm patterning to differentiate lung endoderm from mouse and human ES cells for eventual use in lung tissue regeneration and disease modeling. She clearly enjoys working at the interface of disease and developmental biology. Outside of lab, her interests include reading, gardening, traveling and spending time with family and friends.