Center for Regenerative Medicine

Ying-Hua Wang, Ph.D.

Ying Hua’s research interest lies in the metabolic regulation in hematopoietic stem cells as well as hematopoietic malignancy. Specifically, his projects focus on the role of the metabolic enzyme, pyruvate kinase M2 (PKM2), in normal hematopoiesis and in leukemia. PKM2, the embryonic form of mammalian PK genes, is expressed in many cancer cell lines and has been shown to promote aerobic glycolysis or the Warburg Effect in cancer. Using genetically modified mouse models that allow switching between distinct catabolic modes, he is trying to address whether metabolism is a driver of the stem cell state and whether aeorobic glycolysis is required for leukemia initiation and/or maintenance.

In 2008, Ying-Hua obtained his Ph.D. degree in immunology from Columbia University, New York where he also served as a Graduate Research Assistant. His thesis work identified a novel mechanism of immune tolerance in peripheral lymphoid organ, which helps to understand the pathogenesis of autoimmunity and provides a potential therapeutic target for autoimmune disease. He joined the Center for Regenerative Medicine in 2009 where he currently holds the position of Postdoctoral Research Fellow.