The genetic programs that control the differentiation of distinct types of neurons in the brain are still largely unknown. In our lab we address this issue in the mammalian cerebral cortex and our main interest focuses on understanding and investigating the molecular pathways that direct the early specification of progenitors to generate distinct types of projection neurons during development. We specifically focus on the early signals that induce differentiation of corticospinal neurons, a clinically relevant neuronal target population that in humans selectively degenerates in ALS (Lou Gehrig’s disease), Hereditary Spastic Paraplegia (HSP), Primary Lateral Sclerosis (PLS), and that is permanently injured in spinal cord injury.

Lab Members
Caroline Rouaux, Ph.D., Research Fellow
Lori Shoemaker, Ph.D., Research Fellow
Simona Lodato, Graduate Student
Alyssa Meleski, Lab Manager