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Research at Mass General
Recent news about scientific and medical research from the Massachusetts General Hospital Research Institute.
Researchers from Massachusetts General Hospital and the Broad Institute of MIT and Harvard have found that analysis of a patient's gut microbiome—the microbial population of the gastrointestinal tract—may predict the likelihood of successful treatment for inflammatory bowel disease with biologic drugs that target immune system activity.
A study led by Massachusetts General Hospital investigators found that 53 percent of individuals seeking pre-travel consultations at clinics across the country who were eligible to receive the measles, mumps, rubella vaccine were not vaccinated during the clinic visit.
Despite dreary weather, hundreds of Massachusetts General Hospital's research staff members enjoyed the annual Research Staff Appreciation Day lunch and ice cream celebration.
Like so many previous monumental moments in her life, Ellen Czahar, assistant and surgical coordinator in the MGH Orthopædics Department, wanted to document it with a snapshot. The empty pack of cigarettes marked the last pack she would smoke as she embarked on a happier, healthier way of life.
Massachusetts General Hospital investigators have identified a surprising mechanism for resistance to immune checkpoint blockade, finding in mouse models of cancer that an antibody-based drug designed to block the immunosuppressive molecule PD-1 is removed from its target T cells by macrophages within minutes of administration.
A study led by Massachusetts General Hospital investigators suggests that following a diet known to reduce the risk of hypertension and cardiovascular disease may also reduce the risk of gout.
The next stage of a Massachusetts General Hospital team's investigation into the therapeutic potential of the hypoxia response—the body's reaction to reduced levels of oxygen in the blood—to treat mitochondrial disease has produced findings that are promising but also reveal some limitations.
A study led by researchers at Columbia University Medical Center and Massachusetts General Hospital revealed that dietary gluten is not associated with heart disease risk in people without celiac disease.
Massachusetts General Hospital investigators have identified silent, seizure-like activity in the hippocampus—a brain structure significantly affected in Alzheimer's disease—in two patients with Alzheimer's disease and no known history of seizures.
Researchers at Partners HealthCare published a study showing that Partners Pioneer ACO not only reduces spending growth, but does this by reducing avoidable hospitalizations for patients with elevated but modifiable risks.
A noninvasive PET imaging method that measures granzyme B, a protein released by immune cells to kill cancer cells, was able to distinguish mouse and human tumors that responded to immune checkpoint inhibitors from those that did not respond early in the course of treatment.
"Science is the scaffolding, the power, the engine that drives society forward. It represents progress and knowledge and answers," said Peter L. Slavin, MD, Massachusetts General Hospital president, at an April 22 rally.
The 2017 Warren Triennial Prize—the most prestigious research prize awarded by Massachusetts General Hospital—was presented on April 5 to James P. Allison, PhD, professor and chairman of Immunology at the University of Texas MD Anderson Cancer Center.
A team of investigators based at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital has devised a means of tracking nanodiamonds noninvasively with magnetic resonance imaging (MRI), opening up a host of new applications.
Massachusetts General Hospital investigators report that an intestinal enzyme previously shown to keep bacterial toxins from passing from the gastrointestinal system into the bloodstream may be able to reduce or prevent the liver damage caused by excess alcohol consumption.
A collaborative study between researchers at Massachusetts General Hospital and Boston University School of Medicine has found evidence implying that alcoholism may have different effects on the reward system in the brains of women than it does in men.
A study led by a Massachusetts General Hospital investigator finds that pretreatment viral levels and immune activation appear to determine the extent of HIV persistence and inflammation during antiretroviral treatment.
A Massachusetts General Hospital-led research team has discovered that the immune cells called macrophages are also essential to the healthy functioning of the heart, helping conduct the electric signals that coordinate the heartbeat.
With the help of genetically engineered mice, scientists at the Massachusetts General Hospital are moving closer to establishing the role that increased intestinal permeability, sometimes called a "leaky gut," plays in chronic inflammatory conditions.
In a new study, a team led by researchers from the Broad Institute of MIT and Harvard, Massachusetts General Hospital and the National Institute of Neurological Disorders and Stroke adds RNA sequencing to the diagnostic toolkit to identify disease-causing mutations buried inside the genome.
People who suffer heart attacks or cardiac arrests in the vicinity of an ongoing major marathon are more likely to die within a month due to delays in transportation to nearby hospitals, according to newly published research from Harvard Medical School.
A study from Massachusetts General Hospital investigators raises the possibility of identifying children with Down syndrome who may also have obstructive sleep apnea without the need for expensive and inconvenient sleep studies.
A PET imaging probe developed by Massachusetts General Hospital investigators appears able to diagnose and stage pulmonary fibrosis—an often life-shortening lung disease—as well as monitor the response to treatment.
Long-term, regular aspirin use was associated with reduced risk of death from several different kinds of cancers, according to data presented at the AACR Annual Meeting 2017.
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