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Research at Mass General
Recent news about scientific and medical research from the Massachusetts General Hospital Research Institute.
A new global collaborative study has confirmed that vitamin D supplementation can help protect against acute respiratory infections.
A study from Massachusetts General Hospital researchers has found that a pattern of gene variants associated with a body type in which weight is deposited around the abdomen increases the risk for type 2 diabetes and coronary heart disease, as well as the incidence of several cardiovascular risk factors.
The first study to evaluate sex differences in academic ranking among academic cardiologists has found that women were significantly less likely than men to be full professors, even when adjusting for factors such as age, years of experience and research productivity that are traditionally associated with academic rank.
Northeastern psychology professor Lisa Feldman Barrett and her colleagues at Massachusetts General Hospital have found that the neurotransmitter dopamine is involved in human bonding, bringing the brain’s reward system into our understanding of how we form human attachments.
Daylight savings time contributes to higher miscarriage rates among women undergoing in vitro fertilization who had had a prior pregnancy loss, according to a new study.
Massachusetts General Hospital investigators have developed a novel approach to analyze brainwaves during sleep, which promises to give a more detailed and accurate depiction of neurophysiological changes than provided by a traditional sleep study.
The effects of a promising new approach to chemotherapy that involves frequent administration of dosage levels much lower than traditionally used appears to rely on the “normalization” of blood vessels within and around a tumor.
Researchers from Weill Cornell Medicine and Massachusetts General Hospital will be conducting a clinical trial to investigate the ability of phenformin – a drug once used to treat diabetes – to improve the results of melanoma treatment.
The executive order restricting individuals from seven Muslim-majority countries from entering the U.S. is “a step backward” for medical education, patient care and biomedical research in this country, write medical department leaders from Massachusetts General Hospital and six other major academic medical centers.
A nearly two-decades-long clinical trial has demonstrated that adding antiandrogen therapy to radiation therapy can improve the survival of prostate cancer patients who have evidence of disease recurrence after radical prostatectomy.
Massachusetts General Hospital investigators report a naturally occurring hormone that plays an important role in fetal development may be the basis for a new type of reversible contraceptive that can protect ovaries from the damage caused by chemotherapy drugs.
A team led by a MassGeneral Hospital for Children physician has developed an assessment that may reduce the need for sleep studies in ruling out the presence of obstructive sleep apnea in people with Down syndrome.
Using a better form of gene therapy, scientists from Harvard Medical School and Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.
Using a novel PET radiotracer, a team of Massachusetts General Hospital researchers has found a way to quantify olfactory sensory neurons and thus improve measurements of olfactory health, a reliable marker of the health of the brain.
Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.
Massachusetts General Hospital investigators describe how use of an advanced form of the commonly used polymerase chain reaction method to analyze circulating tumor cells may greatly increase the ability to diagnose early-stage cancer, increasing the likelihood of successful treatment.
Public health experts from Massachusetts General Hospital and the Harvard T.H. Chan School of Public Health applaud the efforts of the U.S. Department of Housing and Urban Development to protect public housing residents from the harmful effects of tobacco exposure and discuss both implementation challenges and possible solutions to ease the burden of transition.
A Massachusetts General Hospital study finds reduced expression of genes involved in the integrity of the blood-brain barrier and the intestinal barrier in those with autism spectrum disorder.
Investigators at Massachusetts General Hospital have found new evidence that the tumor necrosis factor receptor type II may be a major target for immuno-oncology treatments, which induce a patient's immune system to fight cancer.
Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs)—treatment-resistant cells responsible for cancer recurrence and metastasis—in breast cancer, as well as a compound that appears to reduce the molecule’s ability to protect TICs from the effects of chemotherapy. Results of the team’s study are being published online in PNAS.
A survey conducted by investigators at the Mongan Institute Health Policy Center at Massachusetts General Hospital (MGH) found that almost one-third of Californians enrolling in individual insurance plans offered under the Affordable Care Act (ACA) in 2014 potentially missed opportunities to receive financial assistance with either premium payments, out-of-pocket costs or both. In their report published in the journal Health Affairs, the researchers note that enrollees who received assistance from certified enrollment counselors were less likely to choose plans that made them ineligible for assistance.
A study led by Massachusetts General Hospital and Icahn School of Medicine at Mount Sinai investigators has linked, for the first time in humans, activity in a stress-sensitive structure within the brain to risk of subsequent cardiovascular disease.
A Massachusetts General Hospital research team, using the kidney as an example, has developed a way to avoid ischemia/reperfusion injury with a new monoclonal antibody that binds its target in a way that is "just right."
A team of researchers from the Massachusetts General Hospital and the Ragon Institute of MGH, MIT and Harvard has found that the most common bacterial community in the genital tract of healthy South African women is associated with a more than four-fold increase in the risk of acquiring HIV.
Researchers from Massachusetts General Hospital led a team that has identified gene mutations associated with a rare congenital condition involving the absence of a nose. Mutations in the same gene have previously been associated with a form of muscular dystrophy.
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