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Research at Mass General
New research suggests that a diet recognized for its ability to reduce risk for hypertension may also prevent gout, plus researchers detect "silent" seizures in Alzheimer's patients.
A recent study suggests that following the Dietary Approaches to Stop Hypertension (DASH) diet may reduce the risk of gout, a painful type of inflammatory arthritis caused by buildup of uric acid in joints.
The study enrolled over 44,000 men with no history of gout. The research team applied two scoring systems to the dietary patterns of participants:
During the 26 years of follow up, 1,731 participants were newly diagnosed with gout. A higher DASH dietary pattern score was associated with a lower risk for gout, while a higher western dietary pattern score was associated with an increased risk for gout.
While these findings need to be confirmed in future interventions, the researchers note that many individuals at risk for gout because of elevated uric acid levels might already be candidates for the DASH diets, since more than half of such individuals also have hypertension.
Hyon Choi, MD, DrPH, Director of the Gout and Crystal Arthropathy Center in the MGH Division of Rheumatology, Allergy, and Immunology, is senior author of the study.<
New research suggests a potential new connection between the devastating memory loss associated with Alzheimer’s disease (AD) and “silent” seizures in the hippocampus, the memory center of the brain.
The small study enrolled two female patients in their 60s with early AD and no known history of seizures. Electrodes were placed on the scalp and surgically implanted on both sides of the brain to better detect seizure activity. Each patient’s brain activity was monitored for 24 to 72 hours.
The implanted electrodes recorded evidence of seizures in the hippocampuses of both patients. Most notably, these seizures primarily occurred when patients were asleep, a critical time for memory consolidation.
“Our novel finding that networks involved in memory function can become silently epileptic could lead to opportunities to target that dysfunction with new or existing drugs to reduce symptoms or potentially alter the course of the disease,” says Andrew Cole, MD, Director of the Mass General Epilepsy Service and senior author of the study.
A recent study led by Alice Lam, MD, PhD, also of the MGH Epilepsy Service and lead author of the current study, demonstrated a novel tool for detecting hippocampal seizures not detectible by scalp electrodes in patients with epilepsy. Cole and his team are working to refine this tool and apply it to AD.
Due to the small size of the study, further research is also needed to validate the results with a broader population.
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