Labs & Resources

The research enterprise at Massachusetts General Hospital includes clinical departments, multidisciplinary thematic centers and research programs.

A listing of research labs, core facilties, resources and other assets of the Massachusetts General Hospital research enterprise.

Analytic and Translational Genetics Unit

The Analytic and Translational Genetics Unit at Massachusetts General Hospital focuses on the interpretation of genome data to aide in the discovery of human disease.

Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research

The Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research at Massachusetts General Hospital is a collaborative of scientists, oncologists, surgeons, radiation oncologists and interventional endoscopists whose mission is to extend and improve the lives of patients with pancreatic cancer.

Cardiovascular Research Center

The Cardiovascular Research Center (CVRC) at Massachusetts General Hospital was founded in 1990 to bridge the gap between the science of heart disease and the practice of cardiovascular medicine.

CCIB

The Massachusetts General Hospital Center for Computational and Integrative Biology is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard.

Center for Cancer Research

Massachusetts General Hospital Cancer Center is committed to eradicating cancer and is fueled by scientific investigation conducted as part of the largest hospital-based research program in the United States.

Center for Human Genetic Research

The Massachusetts General Hospital Center for Human Genetic Research is a multidisciplinary crossdepartmental center with the central mission of facilitating the genetic research cycle.

Center for Integration of Medicine & Innovative Technology

A non-profit consortium of Boston's leading teaching hospitals and universities, the Center for Integration of Medicine & Innovative Technology (CIMIT) fosters interdisciplinary collaboration among world-class experts in translational research, medicine, science and engineering, in concert with industry, foundations and government, to rapidly improve patient care.

Center for Regenerative Medicine

The Center for Regenerative Medicine is dedicated to understanding how tissues are formed and may be repaired in settings of injury and disease.

Center for Reproductive Biology

The Vincent Center for Reproductive Biology consists of basic and clinical scientists whose primary research emphasis includes infertility, aging and cancer as they pertain to the ovary and uterus. The center provides an optimal environment for individuals who are interested in integrating clinical and basic sciences and have a strong desire to pursue a career in academic research.

Center for Systems Biology

The goal of the Massachusetts General Hospital Center for Systems Biology is to analyze, at a systems level, how biological molecules, proteins and cells interact in both healthy and diseased states.

Center for the Study of IBD

CSIBD is a Research Center focused on IBD-oriented research at Massachusetts General Hospital and affiliated institutions sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

Center for Translational Pain Research

The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic, and cancer pain conditions by using a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.

Clinical Research Center

Clinical Research Center conducts clinical research, including the use of specialized analyses and procedures for approved studies.

Codman Center for Clinical Effectiveness in Surgery

The Codman Center for Clinical Effectiveness in Surgery is is an academic and service program established by the Department of Surgery to encourage and support surgical outcomes research at Mass General.

Cutaneous Biology Research Center

To achieve that goal the CBRC maintains an environment conducive to collaboration with industrial partners to disseminate the fruits of fundamental research from the CBRC.

Health Decision Sciences Center

The Health Decision Sciences Center conducts shared decision making research and measures the quality of decisions.

Immunology & Inflammatory Diseases

Mass General’s CIID is a multidisciplinary research center focused on basic mechanisms of immune-mediated inflammatory diseases.

MIND / Neurology Research

The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people living with neurodegenerative disease.

Neurological Clinical Research Institute

The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

Transplantation Biology Research Center

The Transplantation Biology Research Center is a multidisciplinary research center working at the interface between basic science and clinical applications in transplantation immunology at Mass General.

Vaccine & Immunotherapy Center

The Vaccine & Immunotherapy Center (VIC) at Massachusetts General Hospital was established to speed the translation of laboratory discoveries into new, cost-effective therapies and treatments to prevent and cure various forms of cancer and infectious diseases.

Wellman Center for Photomedicine

The Wellman Center for Photomedicine at Massachusetts General Hospital investigates the effects of light on human biology and develops light-mediated, minimally invasive diagnostic and therapeutic technologies.

Advancing Understanding of Mechanisms of Hepatitis-Related Liver Disease – Chung Laboratory

Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C virus, persist in the liver and cause liver damage. Our projects will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.nonresponders or ineligible to receive current treatments.

Akito Nakagawa, PhD

Akito Nakagawa researches the identification of small molecules that modulate gas binding properties of human hemoglobin at Massachusetts General Hospital.

Albers Lab at MIND - Mark W. Albers

The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.

Alexander G. Marneros, M.D., Ph.D.

Alexander G. Marneros, MD/PhD Assistant Professor, Department of Dermatology, Harvard Medical School Dermatology Attending, Massachusetts General Hospital

Allan Goldstein Lab

My laboratory is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility.

Allen Steere, MD

The Steere Laboratory does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity, and to develop diagnostic tests.

Allergy Clinical Research Unit

The Allergy Clinical Research Unit conducts clinical "translational" research and drug trials of allergic and immunologic diseases, including asthma, chronic rhinosinusitis, nasal polyopsis, drug allergy, hereditary angioedema (HAE) and food allergy.

Andrew D. Luster, MD, PhD

The Luster Laboratory investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

Andrew Tager, MD

The Tager Laboratory investigates (1) pulmonary and dermal fibrosis, focusing on the roles lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), and (2) HIV immunopathogenesis, using a novel mouse model of HIV infection.

Anesthesia Center for Critical Care Research

The Anesthesia Center for Critical Care Research (ACCCR) at Massachusetts General Hospital aims to develop novel, paradigm-changing therapeutic strategies to improve outcomes in critically ill patients.

Anna Mandinova, M.D., Ph.D.

Anna Mandinova, M.D., Ph.D. Principal Investigator Biologist (Dermatology) Massachusetts General Hospital

ARDS Network Clinical Coordinating Center

The Acute Respiratory Distress Syndrome (ARDS) Network Clinical Coordinating Center coordinates randomized controlled trials for patients with ARDS.

Aryee Lab

Martin J. Aryee, PhD, Computational Methods for Genomics and Epigenomics

Athinoula A. Martinos Center for Biomedical Imaging

The Athinoula A. Martinos Center is committed to developing novel techniques for imaging biological systems and biologically relevant materials, and to applying these techniques toward a more comprehensive understanding and better care of the human mind and body.

Aylwin Ng

Integrative systems biology of microbial sensing, autophagy, innate immune regulation and programming.

Bacskai Lab at MIND

Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.

Bardeesy Lab

Research topics include: pancreatic ductal adenocarcinoma

Benes Lab

Research topics include: the response to cancer therapeutics, the molecular basis of sensitivity to specific drugs and how to identify the genetic variations affecting the response to targeted therapies

Benjamin Medoff, MD

The Medoff Laboratory studies the pathogenesis of pulmonary inflammation, specifically the role of T cells in mediating inflammatory lung diseases.

Berezovska Lab - Presenilin Group Alzheimer Research Unit

The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.

Bernards Lab

Research topics include: Neurofibromatosis-1 (NF1)

Bernstein Lab

Our laboratory applies high-throughput sequencing-based technologies to characterize chromatin structure genome-wide in human and mouse.

Bhan Lab

Mucosal Immunology and Inflammatory Bowel Disease

Bianchi Sleep Informatics Laboratory

Dr. Bianchi's Sleep Informatics Laboratory focuses on understanding human sleep, in health and disease, through a combination of diverse analytical methods and novel device technology.

Bin Zheng, Ph.D

Our lab studies metabolic signaling in skin diseases, particular in melanoma.

Binglan Yu, PhD

Binglan Yu researches blood transfusion and blood substitutes with the goal of making transfusion of human blood stored for prolonged periods a safer clinical process.

Bioengineering Laboratory

The Bioengineering Laboratory continues its tradition of innovation in the area of joint engineering and biomechanics.

Birrer Lab

Research topics include: molecular biology of gynecologic cancer; novel therapeutics; genomics of ovarian cancer; clinical trial design; early detection technologies.

Bobby J. Cherayil, MD

Experiments carried out by our group are directed at understanding the mechanisms that regulate intestinal innate immune responses to pathogenic and commensal bacteria.

Body Dysmorphic Disorder Clinic & Research Unit

The Research Unit currently focuses on studies regarding the treatment of BDD as well as the factors that contribute to the development and maintenance of BDD.

Bone Marrow Transplant Clinical Research

The clinical mission of the Bone Marrow Transplant Clinical Research Lab is to provide a comprehensive range of transplant-related services to patients with hematologic malignancies and other potentially life-threatening blood dyscrasias. Its research mission is to develop novel methods of allogeneic stem cell transplantation to maximize the separation of graft versus host disease (GVHD) and graft versus tumor (GVT) effect in both the HLA-matched and mismatched settings.

Boucher Lab

As part of the Edwin L. Steele Laboratory for Tumor Biology, the Boucher Laboratory analyzes delivery of oncolytic viruses and large therapeutic agents in tumors and tumor cell migration and metastasis.

Brack Lab

Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.

Brain Trauma Lab

The Brain Trauma Lab is aimed at learning how to better treat the millions of children with brain trauma and similar problems, now and in the future.

Brain Tumor Stem Cell Lab

The Brain Tumor Stem Cell Lab develops novel therapeutic strategies for glioblastoma through a better understanding of the biological and molecular characteristics of glioblastoma stem cells

Breakefield Laboratory - Xandra O. Breakefield

The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

Breast Cancer Clinical Research

Our program is on the forefront of investigation to find better therapies, improve diagnostics, and develop less invasive, breast-sparing surgical techniques for the treatment of breast cancer.

Breast Imaging Research

The Breast Imaging Research program at the Massachusetts General Hospital Department of Radiology is dedicated to improving breast cancer detection and diagnosis in order to reduce the death rate of breast cancer.

Bruce A. Morgan, Ph.D

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Brugge research

Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.

Buonanno & Vaina Lab

Neurology of Vision research laboratory for Ferdinando S. Buonanno and Lucia M. Vaina at Massachusetts General Hospital

Cardiac Anesthesia Lab

Research within the Cardiac Anesthesia Lab at Massachusetts General Hospital advances the evolving field of cardiac anesthesiology and improves outcomes for both adult and pediatric patients.

Cardiac MR PET CT Program

The Cardiac MR PET CT Program at Massachusetts General Hospital is dedicated to developing, evaluating and assessing novel imaging techniques for cardiovascular conditions.

Cardiac Psychiatry Research Program

The Cardiac Psychiatry Research Program (CPRP) aims to improve the mental health and medical outcomes of patients with heart disease.

Cardiac Surgery Lab

Cardiac surgery research at the Massachusetts General Hospital Corrigan Minehan Heart Center offers patients the most promising therapies based on the latest scientific evidence.

Cardiothoracic Transplantation Laboratory

The Cardiothoracic Transplantation Laboratory at Massachusetts General Hospital uses state-of-the-art molecular and cellular techniques to study transplantation tolerance, acute/chronic rejection, innate immunity, xenotransplantation and whole organ bioengineering for heart and lung transplantation models.

Cardiovascular Clinical Research Lab

The Cardiovascular Clinical Research Lab seeks to improve clinical diagnosis and treatment of cardiovascular diseases.

Cash, Sydney S., PhD - Cortical Physiology Laboratory

We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.

Cellular & Molecular Radiation Oncology Laboratory

Working at the cellular and molecular levels, our studies cover a range of topics, including mechanisms of cell death, DNA damage induction and repair processes, bystander effects, and cancer genetics.

Cellular Therapy and Neural Regeneration for Intestinal Neuropathies

Our overall goal is to continue to characterize neural stem cells and to study their role in ENS regeneration in health and response to disease, as well as using the NSCs as possible cell-therapy for various forms of intestinal neuropathy including Hirschsprung’s disease.

Center for Applied Clinical Investigation

The Center for Applied Clinical Investigation (CACI) is a training and research center where scientific rigor is used to examine clinical practice and to determine risks and outcomes associated with the variables that comprise patient care.

Center for Cancer Research

Thank you for your interest in this lab at the Mass General Center for Cancer Research.

Center for Child & Adolescent Health Research and Policy

Advancing lifelong health within and beyond healthcare settings

Center for Computational and Integrative Biology

The Center for Computational and Integrative Biology provides support for investigators at the hospital and across Boston through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis, microarray analysis, and research laboratory automation.

Center for Engineering in Medicine

We are scientists, engineers and physicians who are bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.

Center for Experimental Drugs and Diagnostics

The MGH Psychiatry Center for Experimental Drugs and Diagnostics (CEDD) focuses on bringing new discoveries in neuroscience and genetics to the clinic.

Center for Molecular Imaging Research (CMIR)

The Center for Molecular Imaging Research (CMIR) at Massachusetts General Hospital and Harvard Medical School researches molecular phenomena in order to develop novel sensing technologies and, ultimately, clinical applications that can save lives.

Chan_Research_1375

Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.

Charles Hales, MD

Major interest in pulmonary hypertension and its treatment with heparin derivatives we have produced which are weakly anticoagulant but strongly antiproliferative for smooth muscle cells, pulmonary emboli detection and smoke inhaltion from fires.

Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory

The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.

Cheng Lab

Currently, our projects, sponsored by the National Cancer Institute, involve human prostate, breast cancer and lung cancer.

Chung Lab

The main research interest of the Chung Laboratory has been studies of the biology of hepatitis C virus infection, the leading cause of chronic viral liver disease in the U.S.

Chung Lab

The overall goal of the Chung Laboratory is to better elucidate the genetic events in gastrointestinal tumorigenesis.

Clark Lab

MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.

Classon Lab

Research topics include: the role of the pRB pathway and the pRB family of proteins (pRB, p107 and p130) in tumorigenesis

Clinical Investigation in Non-Alcoholic Fatty Liver Disease

Our research focuses on understanding the pathogenesis of non-alcoholic fatty liver disease.

Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag

Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag Clinical Research

Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

Cole, Andrew J., Epilepsy Clinical Research

Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.

Colvin Lab

Dr. Colvin's laboratory is now primarily focused on the role of T regulatory cells in spontaneous acceptance of renal allografts in mice.

Cost Effectiveness of Preventing AIDS Complications (CEPAC)

Cost Effectiveness of Preventing AIDS Complications (CEPAC) is an HIV clinical modeling team that compares the effectiveness of different HIV treatment strategies, in collaboration with investigators around the world.

Cowan Lab

Modeling Cardiovascular and Metabolic Disease with Human Pluripotent Stem Cells

Craniofacial Developmental Biology Laboratory

Advances in clinical treatment of congenital craniofacial malformations require improved understanding of the developmental genetic basis of facial morphogenesis. Our goal in the Craniofacial Developmental Biology Laboratory is to investigate fundamental genetic regulation of facial development, with a focus on translating basic science discoveries to clinical advances. We perform research on palate development and neural crest cell biology.

Critical Care Translational Medicine Group

The Critical Care Translational Medicine Group designs, oversees and coordinates international trials in acute respiratory distress syndrome (ARDS) and sepsis.

Cusack Laboratory

Research topics in the Cusack Laboratory include: molecular targeted therapies for colorectal cancer, melanoma, Merkel cell cancer and carcinomatosis, and improving delivery of surgical cancer care in resource-limited settings.

David Christiani, MD, MPH

Molecular Epidemiology of ARDS: Under the direction of David Christiani, MD, MPH, our laboratory examines genetic and environmental factors that may impact the development and progression of acute respiratory distress syndrome (ARDS).

Davidson Lab

Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.

Demet S. Sulemanji, MD

Demet S. Sulemanji researches the use ventilation strategies in critically ill patients with a variety of lung diseases.

Di Tomaso Lab

Research topics include: vaascular physiology of neurofibromatosis type 2 tumors

Diabetes Research | David Altshuler, MD PhD

The Alshuler lab focuses on studies of human genome sequence variation as a route to understanding the inherited basis of common human diseases, with a major focus on type 2 diabetes.

Diabetes Research Center

The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.

Diabetes Research Center - Clinical and Translational Research

For over two decades, the Mass General Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.

Diabetes Unit Type 2 Diabetes Laboratory

The Type 2 Diabetes Laboratory focuses on studies relating to insulin resistance in type 2 diabetic patients.

Dickerson Lab

Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.

Difiglia Laboratory - Cellular Neurobiology

Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.

Dighe Lab

Research and development of expert system software for pathology interpretations.

Division of General Academic Pediatrics

The Division of General Academic Pediatrics, in the Department of Pediatrics, is an internationally-known academic research division dedicated to improving the health of children and adolescents.

Division of Global Health

The Division of Global Health (DGH) at MassGeneral Hospital for Children is led by Division Chief Dr. Patricia Hibberd and includes energetic faculty members and senior research fellows. The Division's primary mission is to build and foster international partnerships for interdisciplinary research, education and service to reduce health disparities and achieve optimal health for children and adolescnts in resource-limited settings of the developing world. Our multidisciplinary team of faculty has significant experience working in the global arena, and in mentoring and teaching future leaders in global health.

Division of Nephrology Research Program

The Division of Nephrology's research programs are directed towards the elucidation of basic cellular mechanisms and the causes, management and potential therapies of kidney disease.

Division of Research in Emergency Medicine

The Division of Research in the Department of Emergency Medicine at Massachusetts General Hospital pursues a highly active research agenda.

Donald Bloch, MD

The Bloch Laboratory investigates the putative infectious agent or agents that initiate autoimmune disease.

Down Syndrome Research Program

We provide innovative opportunities for your child to participate in research.

Dr. Cosmas Giallourakis

We study genetics of intestinal diseases.

Dr. Deanna Nguyen

We are interested in studying the role of actin regulation in the pathogenesis of inflammatory bowel disease.

Dr. Dinesh Patel Arthroscopy Learning Laboratory

The Dr. Dinesh Patel Arthroscopy Learning Laboratory is a state-of-the-art learning lab with multiple arthroscopy learning stations.

Dr. Kate Jeffrey - Epigenetic Control of Innate Immunity

Epigenetics is a general term encompassing any and all mechanisms that govern gene expression patterns without modifying the underlying DNA sequence. We are interested in how “epigenetic” mechanisms such as histone modifying enzymes and non-coding RNA regulate inflammation and antiviral immunity.

Dr. Lee F. Peng

High-throughput screening of novel cell culture models of HCV-host interactions

Dryja Lab

Ophthalmic pathology, hereditary diseases of the eye, new therapies for eye disease

Duda Lab

Research topics include: solid tumor cellular biology; bone marrow-derived cells in tumor angiogenesis and cancer progression.

Dyson Lab

Research topics include: E2F - and pRB-; tumorigenesis

Edwin L. Steele Laboratory for Tumor Biology

The Edwin L. Steele Laboratory is committed to improving the prevention, detection and treatment of cancer in patients through a better understanding of tumor pathophysiology and host-tumor interactions.

Eichler Lab

Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.

Elizabeth Goodman, MD

The Goodman lab is dedicated to decreasing the burden of disease, particularly related to obesity, cardiovascular disease and diabetes, among disadvantaged youth, their families and communities.

Ellisen Lab

Research topics include: P53 and human tumorigenesis; breast cancer

Emergency Medicine Network

The Emergency Medicine Network's (EMNet) mission is to advance public health objectives through diverse projects in emergency care, particularly through multicenter clinical research.

Emergency Medicine Research Project Inventory

The MGH Department of Emergency Medicine is home to many ongoing research projects which include studies on cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.

Emergency Medicine Research Project Inventory

The MGH Department of Emergency Medicine is home to many ongoing research projects which include studies on cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.

Emmanuel Buys, PhD

Emmanuel Buys investigates the role that soluble guanylate cyclase (sGC) plays in the development of both cardiovascular disease and open angle glaucoma, testing sGC-targeted strategies for disease prevention, detection, and treatment.

Endocrine Cancers Clinical Research

The Program in Endocrine Malignancies is dedicated to the diagnosis and therapy of benign and malignant tumors of the endocrine glands. The physicians affiliated with this center have expertise in the diagnosis and treatment of benign and malignant tumors of the thyroid, parathyroid, and adrenal glands as well as the tumors of the endocrine pancreas.

Endocrine Unit Research

Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.

Endocrine Unit: Bastepe Laboratory

The Bastepe Laboratory investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.

Endocrine Unit: Bergwitz Laboratory

Our research focuses on inborn errors of phosphate metabolism and the endocrine regulation of phosphate homeostasis with an emphasis on the metabolic and homeostatic effects of phosphate.

Endocrine Unit: Demay Laboratory

The Demay Laboratory is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.

Endocrine Unit: Divieti Pajevic Laboratory

The Divieti-Pajevic Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone metabolism.

Endocrine Unit: Kobayashi Laboratory

The Kobayashi Laboratory investigates the genetics of skeletal development.

Endocrine Unit: Kronenberg Laboratory

The Kronenberg laboratory uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.

Endocrine Unit: Mannstadt Laboratory

Research in the Mannstadt Laboratory focuses on diseases of the parathyroid glands and mineral metabolism.

Endocrine Unit: Shimada Laboratory

The Shimada Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone development and remodeling.

Engelman Lab

Research topics include: lung cancer; targeted therapies; molecular fingerprinting; sensitivity and resistance to targeted therapies, PI3K signaling pathways and EGFR inhibitors in cancer.

Epidemiologic and Translational Research in Digestive Diseases - Dr. Andrew Chan

Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.

Ethan A. Lerner, M.D., Ph.D.

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Experimental Organ Transplantation Laboratory

The Experimental Organ Transplantation Laboratory in the Massachusetts General Hospital Transplantation Biology Research Center focuses on developing tolerance-inducing strategies utilizing a preclinical model of pig-to-baboon xenotransplantation.

Fernandez-Del Castillo Lab

The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

Fisher Lab

Our group studies cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy as well as prevention of melanoma and other human cancers

Flaherty Lab

Alice W. Flaherty, MD, PhD has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.

Frosch Lab

My laboratory is interested in the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.

Fuchs Lab

The Fuchs Lab researches prevention and treatment strategies for liver fibrosis and liver cancer as well as development of noninvasive techniques for imaging liver fibrosis.

Fukumura Lab

Research topics include: nitric oxide; angiogenesis; tumor microcirculation; intravital microscopy; tumor microenvironment

Galloway Lab

Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

Garkavtsev Lab

Research topics include: mechanisms governing the development of brain tumors

Gastrointestinal Cancers Clinical Research

The Tucker Gosnell Center for Gastrointestinal Cancers is the first center of excellence in the Harvard system that focuses on integrated multidisciplinary care and research for hepatic and biliary malignancies.

Geijsen Lab

My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.

Genetic Engineering Laboratory

The Genetic Engineering Laboratory in the Transplantation Biology Research Center (TBRC) focuses on understanding the immune response to porcine xenografts, engineering swine for use as solid organ xenotransplantation donors and developing porcine stem cells for use in large animal models of potential stem cell therapies.

Genetics Program

The Schizophrenia Program is involved in a wide range of genetic research projects in collaboration with genetic laboratories at Harvard Medical School and other institutions.

Genitourinary Cancers Clinical Research

The clinical research program of the Claire and John Bertucci Center for Genitourinary Cancers is a multidisciplinary effort to understand cancer biology, discover novel agents and improve treatment outcomes for patients with genitourinary malignancies including cancers of the prostate, bladder and kidney.

Gerontology Research

The Geriatric Neurobehavioral Clinic at Massachusetts General Hospital offers a multidisciplinary and individualized approach to the diagnosis of persons with memory disorders.

GI Cancers – Daniel C. Chung Laboratory

Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.

Giallourakis Laboratory

We study genetics of intestinal diseases.

Gian Paolo Dotto, M.D., Ph.D.

G. Paolo, Dotto, MD, PhD Professor Massachusetts General Hospital Cutaneous Biology Research Center Building 149, 13th Street Charlestown, MA 02129 Tel: (617) 724-9538 Fax: (617) 726-9572 Email: gdotto@partners.org

Gilbertson Lab

Our laboratory develops information systems and robots to support the diagnostic laboratory, the diagnostic process and the communications from the lab to the clinicians, researchers and patients.

Gomez-Isla Lab

Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

Gomperts Lab

The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

Grabowski Lab

Research topics include: endothelial cell function; imaging platelet thrombosis; blood rheology and thrombosis; hemolytic uremic syndrome

Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab

Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

Grewo Lim, PhD

Grewo Lim researches the effect of gene expression on the behavioral interaction between pain and opioid tolerance, exploring the potential use of opioid therapy in chronic pain management.

Gynecologic Cancer Clinical Research

The Gillette Center for Gynecologic Oncology has become one of the nation's outstanding centers for clinical research in gynecologic malignancy. The center has had a strong leadership role at every level of development of therapies for women's cancers, from preclinical drug development, to Phase I and II trials, to Phase III cooperative clinical trials.

Haber Lab

Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer

Haigis Lab

The Haigis laboratory studies how mutations in different members of the Ras family of oncogenes contribute to colorectal cancer.

Hand Surgery Clinical Research

One of the most productive clinical research units in hand surgery, we address all aspects of recovery from hand and arm injury and illness.

Harris Orthopaedics Lab (HOL)

The Harris Orthopaedics Lab comprises preclinical biomechanical research and biomaterials testing along with clinical research involving in vivo follow-up of implant performance.

Hart Lab

Research topics include: modeling neurodegenerative disease in C. elegans; notch signaling in the adult nervous system; osmotic stress response and aging; quiescence and sensory signaling; lipid homeostasis

Harvard Orthopedic Trauma Research Division

The Harvard Orthopedic Trauma Research Division is an inter-institutional, multi-disciplinary team dedicated to understanding the human biological and clinical processes associated with traumatic orthopedic injuries.

Harvard Program in Refugee Trauma

The Harvard Program in Refugee Trauma has spent 25 years caring for the health and mental needs of survivors of mass violence and torture through a combined practice of clinical experience and medical research.

Harvard Reproductive Endocrine Sciences Center

Supported by the National Institute of Child Health and Human Development (NICHD) for close to two decades, the Harvard Reproductive Endocrine Sciences Center builds and sustains the careers of investigators interested in the field of reproductive science.

Head & Neck Cancers Clinical Research

The Center for Head and Neck Cancers is a longstanding multidisciplinary clinical and scientific program that arose from a foundation established by world-renowned clinicians at Massachusetts General Hospital (MGH) and the Massachusetts Eye & Ear Infirmary (MEEI).

Held Lab

Research topics include: apoptosis; DNA damage and repair; oxidative stress; radiation-induced bystander effects; heavy ion radiation biology

Hematologic Malignancies Clinical Research

The Hematologic Malignancies Program encompasses research regarding leukemia, lymphoma and multiple myeloma, incorporating a substantial commitment to the understanding and use of stem cells in these diseases. It is closely integrated with the Bone Marrow Transplant Program, sharing commitment, faculty and research efforts.

Hematopoietic Cell Transplantation Laboratory

The Hematopoietic Cell Transplantation Laboratory in the Transplantation Biology Research Center studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.

Hersch Laboratory, Steven M. Hersh, MD, PhD

Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.

Higgins Lab

I study the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.

Hochedlinger Lab

Research topics include: pluripotency and nuclear reprogramming

Hochedlinger Lab

Our lab tries to understand the role stem cells play in normal development and disease.

Hock Lab

Research topics include: transcription factors in blood development and leukemia

Hock Lab

Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.

Hodin Lab

The major focus of the laboratory is to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia.

Huajun Feng, PhD

The Feng Laboratory at Mass General studies the modulation of ion channels by general anesthetics using molecular biology, biochemistry andelectrophysiology techniques. The laboratory also researches the mechanism and treatment of epilepsy and seizures as well as their related complications.

Huang Lab

Research topics include: spontaneous tumors and their isograft models; histopathology; pathophysiology

Hughes Lab

The Hughes Lab develops a cancer risk assessment software (Hughes riskApps™) that focuses on increasing the quality and efficiency of care while decreasing cost.

Hyman Lab

The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

Iafrate Lab

We have established a broad cancer genotyping platform, termed SNAPSHOT, which detects recurrent mutations in DNA from archived pathology specimens. This platform is allowing for a molecular stratification of cancer patients, and in some cases allowing for placement of patients into trials of novel agents that target specific mutated gene products.

Iliopoulos Lab

Research topics include; biology of tumor suppressor genes and tumor angiogenesis

Immunobiology Laboratory Type 1 Diabetes Research

The Mass General Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.

Informing the management of gastrointestinal cancers and diseases using simulation modeling - Dr. Chin Hur

Our research focuses on applying outcomes methodologies to the clinical field of gastroenterology. Specific examples include the use of decision-analytic modeling to perform comparative effectiveness research regarding the screening and management of various gastrointestinal cancers and diseases.

Institute for Technology Assessment (ITA)

The Institute for Technology Assessment (ITA) conducts health outcomes research to guide the development, evaluation and utilization of medical technologies that improve the quality and cost-effectiveness of medical care.

Intestinal epithelial cell homeostasis – Mizoguchi Lab

Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.

Intestinal Innate Immunity Group

Experiments carried out by the Intestinal Innate Immunity Group are directed at understanding the mechanisms that regulate intestinal innate immune responses to pathogenic and commensal bacteria.

Jain Lab

Research topics include: tumor microenvironment; angiogenesis and lymphangiogenesis; metastasis; in vivo imaging; translational research; drug delivery, nanotechnology, mathematical modeling

James M. Perrin, MD

The Perrin group studies chronic health conditions in children and adolescents, with particular focus on autism spectrum disorders (ASD). Recent work has examined care improvement for children with ASD and racial and ethnic disparities in autism diagnosis and care. The team also provides evidence to support decision-making regarding newborn genetic screening and has examined recent policy and changes regarding public programs supporting children with disabilities (the Supplemental Security Income [SSI] program).

James Moon, PhD

The Moon Laboratory investigates basic issues of CD4+ T cell tolerance by directly tracking endogenous antigen-specific populations in mice and humans.

Jeffrey B. Cooper, PhD

The Center for Medical Simulation for Medical Simulation advances patient safety by teaching and study of the actions of healthcare providers and educators using simulation. The provider focus is on crises management and teamwork; instructor training focuses on debriefing and development of a learner-centered approach. Research generally studies provider behavior and instructional methods.

Jenny W. Rudolph, PhD

The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. We also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.

Jesse Roberts Jr. Laboratory

The Roberts Laboratory is devoted to investigating novel mechanisms and developing new therapies for important pediatric lung diseases.

Jin Mo Park , Ph.D.

Assistant Professor of Dermatology Harvard Medical School Assistant Biologist (Dermatology) Massachusetts General Hospital

Joseph El Khoury, MD

The El Khoury Laboratory investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.

Joung Laboratory

The Joung laboratory utilizes engineered zinc finger, transcription activator-like effector (TALE), and RNA-guided CRISPR/Cas-based systems to create sequence expression alterations in living cells and organisms.

Kaplan Lab

At the MGH Weight Center, we believe that treatments for obesity that are safe and effective will be discovered only through ongoing research to find the answers to these and other questions.

Katia Georgopoulos, Ph.D.

Katia Georgopoulos, Ph.D. Professor of Dermatology Harvard Medical School Biologist (Dermatology) Massachusetts General Hospital

Kazantsev Drug Discovery Lab

The Kazantsev lab is focused on discovering therapeutic agents for Huntington's and Parkinson's diseases using high throughput screening, rational drug design, and medicinal chemistry lead optimization.

Keith W. Miller, MA, D Phil, AM

The Miller laboratory focuses on elucidating the molecular mechanisms by which general anesthetics act to produce anesthesia and its side effects.

Kovacs Lab, Neurobiology of Disease Laboratory at MIND

Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

Kristin White, Ph.D.

Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

Kuter Lab

Research topics include: thrombopoietin; thrombocythemia

Laboratory for Lipid Medicine and Technology

The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.

Laboratory for Musculoskeletal Research and Innovation (LMRI)

The LMRI performs basic and pre-clinical research in bone and vascular tissue engineering, fracture and bone graft healing, implant infection, implant osseointegration, tendon healing and complications related to orthopaedic trauma.

Laboratory for Musculoskeletal Tissue Engineering

The mission of the Laboratory for Musculoskeletal Tissue Engineering is to conduct cutting edge research in tissue engineering and regenerative medicine for repairing and regenerating musculoskeletal tissues. Programs have been developed in three primary areas: 1) articular cartilage repair and regeneration; 2) meniscal repair and replacement; and 3) photochemical tissue bonding to promote healing.

Laboratory of Gastrointestinal Epithelial Biology

The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota.

Laboratory of Molecular Endocrinology

The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.

Lamont Lab

Research topics include: clinical epidemiology and health services research in cancer

Langenau Lab

Self-renewal is responsible for the indefinite replicative potential found in malignant cells and is likely found in residual cell populations that evade conventional therapy and lead to relapse. Uncovering downstream molecular pathways that regulate self-renewal will be integral to identifying novel drugs for the treatment of cancer.

Large Animal Organ Transplantation Section

The Large Animal Organ Transplantation Section in the Transplantation Biology Research Center at Massachusetts General Hospital comprises three laboratories investigating tolerance induction in transplantation.

Lauer Laboratory – Immunology of Viral Infections in Humans

Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.

Lipid Metabolism

Lipid Metabolism research activities center on cholesterol trafficking in and out of cells and the proteins that control this movement.

Louis Lab

David N. Louis' research interests include glioma, glioblastoma, molecular genetics, molecular pathology and therapeutics

Lubitz Lab

The Lubitz Lab focuses on improving the quality of care for patients with thyroid, parathyroid and adrenal disorders.

M. Amin Arnaout Laboratory

Our laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

Madhusmita Misra, MD

The Misra group studies neuroendocrine and bone alterations in conditions spanning the nutritional spectrum.

Maheswaran Lab

Research topics in the Maheswaran Lab include: tumorigenesis, breast cancer and cancer genetics.

Masao Kaneki, MD, PhD

Masao Kaneki investigates clinical data to help develop new strategies to improve the clinical outcome of critically ill patients with conditions like sepsis or burn injuries, and chronic inflammation-mediated human diseases like diabetes.

Mass General Imaging Global Health Programs

Mass General Imaging's Global Health Programs are dedicated to addressing unmet medical imaging needs and healthcare disparities for vulnerable and crisis-affected populations.

Mass General Sports Performance Center

The Mass General Sports Performance Center integrates state of the art technology with the clinical expertise of Mass General Sports Medicine physicians, certified athletic trainers, biomechanists, therapists, nutritionists and certified strength and conditioning coaches to critically and scientifically analyze athletic activities and develop individualized exercise and fitness programs.

Massachusetts General Hospital Optical Coherence Tomography (OCT) Registry

Massachusetts General Hospital researchers are spearheading an international effort to study optical coherence tomography (OCT), an imaging technology that could help doctors identify the vulnerable coronary plaques that cause heart attacks or sudden cardiac death.

MassGeneral Institute for Neurodegenerative Disease (MIND)

The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.

McClatchey

Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity

Medoff Lung Immunology Laboratory

The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury.

Melanoma Clinical Research

The Center for Melanoma draws upon the specialized expertise of physicians and researchers from the Departments of Dermatology and Radiation Oncology, and the Divisions of Surgical Oncology, Transplant Surgery, Hematology and Oncology, and Dermatopathology.

Membrane Biology Lab

Membrane proteins play critical roles in the brain. The Membrane Biology Lab studies ATP-hydrolyzing enzymes that control sodium, potassium and calcium movements. Molecular, cellular and biochemical approaches are used to study structure, function and physiology. Mutations found in human diseases, such as dystonia, are being studied in mutant mice.

Mental Health and the Media

The mission of the Center for Mental Health and Media is to destigmatize mental illness, comfort and educate families about optimal development, and to change the public's outdated and inaccurate perceptions of the nature, causes and treatment of mental illness.

MGH Nuclear Medicine and Molecular Imaging (NMMI)

NNMI encompasses Clinical Service, Education and Research and the MGH PET Core. The research areas are organized into three Centers of excellence: PET Radiochemistry Discovery (CPRD); Advanced Radiological Sciences (CARS); and Translational Nuclear Medicine and Molecular Imaging (CTNMI)

Michaelson Lab

Research in the Michaelson Lab focuses on development of databases on several cancers, testing systems and various analyses.

MingMing Ning MD, MMSc, Clinical Proteomics Research Center

The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.

Mizoguchi Lab

The Atsushi Mizoguchi laboratory focuses on dissecting the gut immune networks and developing cell-specific and tissue-specific therapeutic measures for digestive diseases.

Moir Lab

Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

Molecular Biology Laboratory

The Molecular Biology Laboratory in the Transplantation Biology Research Center at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.

Molecular Neurosurgery Lab

Research in the Molecular Neurosurgery Lab focuses on the use of herpes simplex virus (HSV) vectors for cancer therapy and gene delivery in the nervous system, with the long-term goal being the therapeutic application of these vectors to patients.

Monoclonal Antibody & Immunotherapy Laboratory

The goal of this laboratory is to investigate the role of immunological events in the pathogenesis of orthopedic malignancies and to develop combinatorial immunotherapeutic strategies for the treatment of orthopedic malignancies with special emphasis on translational research.

Mostoslavsky Lab

Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair

Motamedi Lab

Research topics include: RNA-mediated epigenetic gene silencing.

Mucosal Immunology, Microbial Defense and Inflammatory Bowel Diseases - Reinecker Laboratory

We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.

Mucosal Inflammation Group

Our focus is to better understand inflammatory processes impacting mucosal surfaces, particularly in the lung and digestive tract.

Munn Lab

Research topics include: leukocyte mechanics and tumor physiology

Murat Bastepe, MD, PhD

Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.

Musculoskeletal Genetics and Regenerative Biology Laboratory (MGRBL)

The MGBRL is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

Naar Lab

Research topics include: molecular mechanisms of gene regulation; the function of co-activators and co-repressors in mediating the action of transcription regulators

Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory

The Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory develops innovative minimally invasive techniques using the body’s natural orifices to perform surgeries.

Neural Prosthetic Lab

The Neural Prosthetic Lab seeks to improve the effectiveness of CNS-based neural prosthetics by understanding how and why neurons respond to electric stimulation. We use this knowledge to develop improved methods of stimulation. Projects focus on retinal prosthetics, DBS and other devices.

Neurochemistry Laboratory

Successfully studying novel chemotherapeutic agents for clinical trials in Alzheimer patients.

Neuroendocrine Clinical Research Program

Learn more about clinical research in the Neuroendocrine Unit at Mass General.

Neuroendocrine Malignancies Clinical Research

The Neuroendocrine Center is one of the premier multidisciplinary clinical and research programs in neuroendocrinology and pituitary tumors in the USA. A recognized international referral center, the Neuroendocrine Center incorporates multidisciplinary expertise from Neuroendocrinology, Neurosurgery, Neurology, Radiation Oncology and Psychiatry.

Neuroendocrine Research Laboratory

Learn more about basic research the the Neuroendocrine Unit at Mass General.

Neuroenteric Research Laboratory - Dr. Braden Kuo

The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.

Neuroimaging Program

The Schizophrenia Program Neuroimaging Investigators use MRI and other imaging technologies to conduct cutting-edge research on the neurobiological basis of schizophrenia.

Neurological Clinical Research Institute

The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

Neurology of Vision Lab

Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

Neuronal Communication and Restoration Lab

The Neuronal Communication and Restoration Lab probes the mechanisms by which individual neurons communicate locally and across cortical areas, and investigate new approaches for reconstituting the line of communication across areas disrupted within the CNS.

Neuro-Oncology Clinical Research

The Stephen E. and Catherine Pappas Center for Neuro-Oncology is a national leader in clinical research and the development of experimental therapeutics for adult malignant brain tumors.

Neuroscience Center

With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.

Neurotherapeutics

The MGH Neurotherapeutics Program encompasses the clinical, research and training activities related to device-based treatments for psychiatric disorders.

Nir Hacohen, PhD

The Hacohen Laboratory investigates the initiation of immune responses, the sensing of pathogens, host-pathogen biology and the development of approaches to discover and model genetic and biochemical networks.

NMR Surgical Laboratory

The Mass General Nuclear Magnetic Resonance Surgical Laboratory investigates biomedical problems related to mechanisms underlying significant medical paradigms, including neoplasia, injury, inflammation, infection and stroke rehabilitation.

Nutt Lab

The primary research interests of our laboratory are the biological and clinical implications of brain tumor heterogeneity.

Online Strategy & Communications

The Online Strategy and Communications Group is a multi-disciplinary team working to develop patient education materials.

Organ Transplantation Tolerance and Xenotransplantation Laboratory

The Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Transplantation Biology Research Center works to develop strategies to induce tolerance across allogeneic and xenogeneic barriers to prevent rejection and relieve the current shortage of donor organs.

Outcomes Research Center

Research at the Outcomes Research Center at Massachusetts General Hospital focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

Padera Lab

Research topics include: the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis

Pancreatic Biology Research Laboratory

The focus of the basic and translational laboratory efforts is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic disease and cancer, specifically the contribution of developmental genes.

Pathology Research Center - Immunopathology Research Unit

Translational Research in Immunology and Transplantation [Image: dendritic cells (green) and foxp3+ cells (red) in an accepted mouse kidney graft]

Pathology Research Center - Molecular Pathology Unit

Basic and translational research with an emphasis on cancer biology

Patricio A. Leyton, MD

Patricio Leyton researches how mutations in bone morphogenetic proteins can result in the development of Primary Pulmonary Arterial Hypertension (PAH).

Patrick L. Purdon, PhD

Patrick Purdon develops and applies novel methods in neuroimaging and biomedical signal processing to study the systems neuroscience of general anesthesia and other altered states of consciousness.

Pediatric Airway, Swallowing and Voice Center

The Pediatric Airway, Swallowing and Voice Center, a collaboration of MassGeneral Hospital for Children and the Massachusetts Eye and Ear Infirmary, specializes in conducting research to treat children with voice disorders and airway management symptoms that affect the ability to eat, breathe or speak.

Pediatric Cancer Clinical Research

The Center for Pediatric Hematology and Oncology is actively participating in clinical trials and translational research. A significant number of our clinical trials are through collaborative efforts with the Children's Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), the New England Retinoblastoma Group and the Hodgkin Lymphoma Consortium.

Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

Research within the Pediatric Sports Endocrine Lab aims to further medical knowledge about the common endocrine issues facing athletes today. In particular, we focus our efforts on establishing findings that lead to the adaptation and improvement of medical care for female athletes.

Pediatric Endocrinology Research Lab

The goal of our laboratory research is to find ways to generate regulated insulin secretion in cells or tissues for pancreatic b-cell replacement therapy in diabetes.

Pediatric Epilepsy Research Lab: Kevin J. Staley, MD

The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.

Pediatric Surgical Research Laboratories

The Pediatric Surgical Research Laboratories focus on areas of Developmental Biology which hold promise for clinical application for birth defects and cancer prevention and treatment.

Physics Research for Radiation Oncology

Research efforts are focused on developing radiation treatment techniques to optimize physical dose conformation to the tumor target volume and to increase the precision of the dose application.

Pillai Lab

"Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia"

Plastic Surgery Research Laboratory

The Plastic Surgery Research Laboratory conducts investigations into tissue engineering of cartilage, mechanisms of neural injury and regeneration, ischemia/reperfusion injury, and transplantation of vascularized limb tissues.

Preffer Lab

Of particular present interest are side populations [SP] cells, which are relatively rare cells found in both the circulation and bone marrow.

Program in Glomerular Disease

The MGH Program in Glomerular Disease is founded with the mission to advance understanding of the molecular mechanisms of urinary protein loss and associated kidney diseases.

Program in Membrane Biology

The MGH Program in Membrane Biology brings together a diverse group of investigators with a common interest in understanding how physiological signals regulate tissue and organ function at the cellular level.

Psychiatric & Neurodevelopmental Genetics Unit Core Lab

Director: Smoller, Jordan, M.D., Sc.D.

Psychiatric Neuroscience: Epidemiology Research

Epidemiology provides a public health perspective on mental health and mental illness in that it is concerned with psychiatric disorders in the general population.

Psychiatric Oncology

In a collaboration between the Department of Psychiatry, consistently rated the best program in the US, and the Mass General Cancer Center, ranked among the top ten in the nation, we are able to complement the research on cancer treatments by focusing on the psychological and behavioral aspects of cancer.

Psychological Evaluation and Research Laboratory (PEaRL)

The Psychological Evaluation and Research Laboratory (PEaRL) is a clinical assessment, research, and training service directed by Mark A. Blais, PsyD, Associate Chief of Psychology at Massachusetts General Hospital (MGH).

Psychopharmacology Lab

The Psychopharmacology Lab research team seeks better medication options to treat schizophrenia symptoms and mitigate the medical problems associated with existing medications.

QPID (Queriable Patient Inference Dossier) Informatics

The QPID (Queriable Patient Inference Dossier) Informatics group includes physicians and computer scientists who are developing a novel platform capable of extracting useful patterns of electronic health record data from clinical data repositories.

Radiation Oncology Biostatistics & Biomathematics

The Division of Biostatistics & Biomathematics supports research-oriented databases and data management needs for Radiation Oncology.

Radiochemistry Program - Vasdev Lab

The Radiochemistry Program at Massachusetts General Hospital is dedicated to discovering new chemistry and evaluating novel PET radiopharmaceuticals for preclinical and clinical imaging studies.

Rajagopal Lab

Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system since there is an abundance of respiratory diseases of unknown cause without cures.

Raje Lab

Research topics include: multiple myeloma; tumor microenvironment; bone disease and myeloma; novel therapies for multiple myeloma

Ramaswamy Lab

Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.

Ramaswamy Lab

Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.

Reproductive Endocrine

Select a topic from this list to view a detailed description of the study:

Reproductive Endocrine Unit All Research

The Reproductive Endocrine Unit in the Endocrine Division at Massachusetts General Hospital hosts a broad-based clinical and basic scientific research program into the scientific basis of reproductive disorders in the human.

Research at the Center for Cancer Risk Assessment

Research at the Center for Cancer Risk Assessment (CCRA) is devoted to advancing all aspects of cancer risk assessment, screening and prevention. The Center has both laboratory and clinical components.

Research in Inflammatory Bowel Diseases - Dr. Ashwin Ananthakrishnan

My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.

Rheumatology Clinical Research Unit

The Rheumatology Clinical Research Unit performs state-of-the-art translational research for patients with immune-mediated and rheumatological conditions.

Riccardo Barbieri, PhD

Riccardo Barbieri analyzes biological systems such as the cardiovascular, central nervous and automatic nervous systems through mathematical modeling, providing a more accurate and noninvasive assessment of these systems.

Richa Saxena, PhD

Richa Saxena studies the genetics of circadian rhythms/sleep disorders and their association with common disease like type 2 diabetes. The lab also investigates the genetics of preeclampsia, and its role in predicting the risk of future cardiovascular disease.

Rivera Lab

Our laboratory uses genomic technologies to identify and characterize pathways implicated in pediatric solid tumors and sarcomas.

Robert Anthony, PhD

The Anthony Laboratory investigates the interplay of inflammation and glycosylation, with the intention of engineering and fine tune responses.

Robert E. Gerszten, MD

The Gerszten Laboratory investigates the molecular basis of injury responses in cardiovascular disease.

Robert Simon, EdD

The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. The lab also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.

Rocco Lab

Research topics in the Rocco Lab include P63 mediators as targets in head and neck cancer.

Rosenberg Lab

We focus on the immunology and pathogenesis of HIV infection with a particular interest in CD4+ T helper cells in persons with acute HIV and long-term non-progressive infection.

Sadri-Vakili Neuroepigenetics Laboratory

The laboratory focuses on identifying epigenetic alterations that regulate gene expression in brain disorders, and investigates whether these alterations are heritable across multiple generations.

Sahay Lab

Our goals are to understand how plasticity mechanisms in the adult brain may be harnessed to modify hippocampal functions in cognition and mood and how alterations in neural circuits contribute to the development of psychiatric disorders. As part of this endeavor, the laboratory has two main areas of focus.

Sam Moskowitz Laboratory (Pediatric Pulmonary Medicine)

Research in the Moskowitz Lab at Massachusetts General Hospital focuses on antibiotic-resistant bacteria such Pseudomonas aeruginosa that cause difficult-to-treat infections in people with cystic fibrosis (CF) or other serious clinical conditions.

Sam W. Lee, Ph.D

Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Research Center Professor MGH/Harvard Medical School

Sarcoma Molecular Biology Laboratory

The Sarcoma Molecular Biology Laboratory conducts studies on molecular biology of sarcoma and mechanisms of multidrug resistance

Sarcomas & Soft Tissue Tumors Clinical Research

The Center for Sarcoma and Connective Tissue Oncology offers a truly multidisciplinary approach to care, including research and clinical trials conducted as part of one of the largest hospital-based programs in the nation.

Scadden Lab

The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.

Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology

I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.

Schmidt Lab

Research topics include: Cyclin D1

Schneeberger Lab

Our laboratory examines the molecular composition and regulation of tight junctions as they pertain to the permeability properties of the lung. A second major goal of our laboratory is to examine the biology of dendritic cells in the lung.

Schwarzschild Lab - Molecular Neurobiology Laboratory

The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.

Scott Harris, MD

The Harris Lab is a multi-disciplinary, inter-departmental group of investigators aiming to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling and bioengineering. In our studies, we apply rigorous quantitative tools to investigate the complex structure-function relationships of healthy and diseased lungs.

Sensorimotor Integration Lab

The Sensorimotor Integration Lab explores the influence of basal ganglia in adaptive learning and motor control in subjects undergoing surgery for movement disorders, such as Parkinson’s disease, while awake.

Settleman Lab

Research topics include: targeted therapies; signaling in cancer; PI3K signaling pathway; EGFR inhibitors in cancer; sensitivity and resistance to targeted therapies

Settleman Lab

Jeffrey Settleman, PhD, assumed a position at the biotechnology company Genentech as Senior Director of Discovery Oncology last April. Since then he has continued to maintain research activities and collaborations at Mass General.

Settleman Lab

Research topics include: targeted therapies; signaling in cancer; PI3K signaling pathway; EGFR inhibitors in cancer; sensitivity and resistance to targeted therapies

Sgroi Lab

My laboratory is currently focused on applying high-throughput DNA microarray and proteomic technologies as a means to predict the clinical behavior of human breast cancer in the setting of specific hormonal and chemotherapeutic regimens.

Sharma Lab

Research topics include: Targeted Anti-cancer Therapeutics on Epidermal Growth Factor Receptor (EGFR)

Shioda Lab

Research topics include: signaling of mammary epithelial cells

Shoulder Biomotion Laboratory (SBL)

The Shoulder Biomotion Lab conducts studies on shoulder joint biomechanics and upper extremity nerve pathology. Our mission is to bridge basic science research with clinical applications to advance shoulder joint treatments.

Skeletal Biology Research Center

The Skeletal Biology Research Center of the Department of Oral and Maxillofacial Surgery does pioneering work to apply advances is biomedical engineering, biomechanics, tissue engineering, and computer-aided surgical planning to the art of reconstruction or congenital and acquired facial deformities.

Smith Lab

Dr. Smith's research focuses primarily on immunology and transplantation, with emphasis on the transplantation pathology of the heart, kidney, and pancreatic islets.

Smoking Cessation Program: Center for Addiction Medicine and Schizophrenia Program

At the Mass General Smoking Cessation Program, people with schizophrenia receive the best in personally tailored behavioral and medication treatment for smoking cessation as well as prevention of relapse to smoking.

Smoller Laboratory

The Smoller Laboratory is working to understand the genetic basis of psychiatric disorders in order to improve diagnosis and treatment.

Stem Cell Biology and Cellular Reprogramming Laboratory – Choi Laboratory

We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.

Stemmer-Rachamimov Lab

Our lab's research focuses on identifying the underlying molecular changes in the lesions and malformations associated with hereditary brain tumor syndromes (neurofibromatosis 1, neurofibromatosis 2, schwannomatosis and tuberous sclerosis), and the identification of activated pathways or events that lead to tumor progression.

Stone Lab

The laboratory is seeking to understand the biochemical processes resulting in atherosclerosis in order to combat this pervasive disease.

Stroke Service Research

Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.

Supko Lab

Research topics include: pharmacokinetic studies of new anticancer agents

Suter Pulmonary Optical Imaging Laboratory

The focus of the Pulmonary Optical Imaging Laboratory is the development and subsequent translation of novel optical diagnostic tools for evaluating the pulmonary airways and lung.

Sweetser Lab

Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.

Syed Shaukat Husain, PhD

Syed Shaukat Husain studies the molecular composition of general anesthesia.

Tanabe Lab

Research topics in the Tanabe Lab include: hepatobiliary cancer, Epidermal Growth Factor and hepatocellular carcinoma.

Tannous Lab - Experimental Therapeutics and Molecular Imaging Laboratory

Bakhos Tannous, PhD – Research focus in molecular Imaging, gene transfer technologies and high throughput screening aiming at finding novel therapeutics against brain tumors.

Tanzi Lab - Genetics and Aging Research Unit

Dr. Rudolph Tanzi is carrying out genome-wide association screens to identify novel genes associated with AD and autism spectrum disorders.

Tearney Lab

My research interests are primarily focused on the development and validation of non-invasive, high-resolution optical imaging methods for disease diagnosis.

Technology Implementation Research Center (TIRC)

The Technology Implementation Research Center conducts translational research relating to orthopedic implants, materials and surgical technologies. Our mission is to dramatically improve the quality of orthopaedic care by leveraging biomechanical and biomaterials research to bring disruptive technology to active clinical use.

Teratology Program

The Teratology Program focuses on the study of the causes of congenital malformations.

Terry Means, PhD

The Means Laboratory combines molecular biology, cellular biology, and genetics to understand the molecular and cellular mechanisms of inflammation and host defense.

TGF-beta signaling in development and disease Mullen Laboratory

Understanding how TGF-beta signaling regulates the activity of coding and non-coding genes in health and disease

The Deborah Kelly Center for Outcomes Research

The mission of the Deborah Kelly Center is to facilitate exemplary obstetrical and gynecologic outcomes-based research in women's health care.

The Laboratory for Tissue Engineering and Organ Fabrication

The Laboratory for Tissue Engineering and Organ Fabrication is designing and building replacement living tissues and organs to ultimately translate to clinical therapies.

The Program in Nutritional Metabolism, Massachusetts General Hospital

The MGH Program in Nutritional Metabolism was formed under the Direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.

The Stott Laboratory

Research topics include: Circulating tumor cells; microfludics and control of the cell microenvironment; imaging.

Thoracic Cancers Clinical Research

Lung cancer is the leading cause of cancer-related mortality in the United States. Despite great advances in the understanding of lung cancer biology, only 15% of patients are alive five years after diagnosis. The research program of the Center for Thoracic Cancers is a multifaceted effort designed to understand thoracic cancer biology, discover novel agents and improve treatment.

Thorsten R. Mempel, MD, PhD

The Mempel Laboratory investigates cell migration and intercellular communction in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.

Thyroid Cancer Research Laboratory

The main focus of the Mass General Thyroid Cancer Research Laboratory, led by Sareh Parangi, MD, is to study certain key genetic and epigenetic changes seen more frequently in those patients who do poorly, and find out how exactly these genetic changes lead to more aggressive cancer behavior in those patients.

Tilo Winkler, PhD

Tilo Winkler studies the effect of bronchoconstriction on regional ventilation to determine how ventilation defects emerge, and identify methods of treatment and prevention. The laboratory also develops new methods for pulmonary imaging and image analysis to improve studies in asthma, COPD, ventilator induced lung injury and other diseases.

Ting Lab

Research Topics Include: Pancreatic ductal adenocarcinoma (PDAC)

TRANSCEND Research Laboratory, Martha Herbert, MD, PhD

TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.

Translational Brain Tumor Immunology Lab

Research in the Translational Brain Tumor Immunology Lab focuses on the development and evaluation of novel therapies for brain tumors.

Translational Center Investigating Prescription Drug Abuse (MIDA)

MIDA is an interdisiplinary collaborative center for the purpose of basic science and clinical research of prescription drug abuse.

Trauma Research Laboratory

Research at the Trauma Research Laboratory targets critical aspects of early trauma care, focusing on clearly defined high-impact goals.

Traumatic Brain Injury Research Laboratory

Our laboratory focuses on secondary mechanisms of acute brain injury including trauma and intracerebral hemorrhage.

Tsao Lab

The overall goal of my research effort is to better understand the genetic basis of melanoma formation and the clinical realization of these molecular events.

Turka Laboratory

The Turka Laboratory in the Transplantation Biology Research Center at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.

Type 2 Diabetes Laboratory Research

The Diabetes Lab focuses on studies relating to insulin resistance in Diabetic patients.

United States Critical Illness and Injury Trials Group (USCIITG)

The USCIIT Group aims to establish a critical care research consortium for the United States.

Urology Research Lab

The aim of the Urology Research Lab is to reduce the burden on our patients by studying the basic mechanisms that are responsible for some of the common urologic diseases.

Urology Research Lab

The Urology Research Lab studies the molecular basis of urologic tumors, including cancers of the prostate, bladder and kidney.

Vaina & Buonanno Lab

Dr. Vaina's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

Vascular Biology Research Laboratory

The Vascular Surgery Research Laboratory is involved in experimental strategies geared towards understanding the pathophysiology of intimal hyperplasia and ischemia reperfusion injury. We are also involved in the development of novel clinically relevant experimental therapies to treat and/or prevent both of these complex problems.

Vascularized Composite Allotransplantation Laboratory

The Vascularized Composite Allotransplantation Laboratory in the Massachusetts General Hospital Transplantation Biology Resource Center investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.

Vasudevan Lab

Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence

Visual Prosthesis Lab

The Visual Prosthesis Lab is working to create a means to restore sight to the blind by sending signals from a digital camera directly into the brain.

Voice Center Research Laboratories

Mass General's Voice Center Research Laboratories are designed to develop novel technologies, biomaterials, devices, and surgical tools for advancing the diagnosis, management and treatment of laryngeal diseases and pathologies that affect voice.

Warshaw Lab

The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

Wasim Q. Malik, PhD

Wasim Malik researches and develops technology for healthcare applications with a focus on neuroscience and neuroengineering.

Wayne Shreffler, MD, PhD

The Shreffler Laboratory is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.

Webster Center for Advanced Research and Education in Radiation

The Webster Center promotes and develops imaging methods that use the lowest achievable radiological exposure to patients and disseminates those methods through dedicated radiation-dose education programs.

Weight Loss and Diabetes Prevention Program

At the Weight Loss and Diabetes Prevention Program, people with schizophrenia receive state-of-the-art intervention for weight loss, diabetes prevention, cardiovascular fitness, and improved overall health.

Whetstine Lab

Research topics include: histone demethylase; chromatin; C. elegans; transcription; epigenetics; JMJC; HDAC

Wilbur Lab

Gynecologic cytopathology, computerization in pathology, translation of molecular methods

Willers Lab

Research topics include: lung cancer; radiation; EGFR; molecular targeting; DNA repair

Wu Lab

We are in the process of identifying molecular and genetic changes of urologic cancers that correlate with the cancer disease behaviors, both clinically and pathologically. The long-term goal of these studies is to develop new diagnostic methods and therapeutic regiments for these cancers.

Xavier Laboratory

The primary research goal of the Xavier Laboratory is to discover and understand the function of important mediators and effectors involved in the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. Current themes of the lab include (1) systems biology of innate and adaptive immunity, (2) functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes, and (3) genetics of Crohn's disease, celiac disease and ulcerative colitis.

Xu Lab

Research topics include: tumor angiogenesis and metastasis; tumor microenvironment

Xu Wu, Ph.D.

My research is focused on studying cellular functions (self-renewal, differentiation, proliferation, and chromatin remodeling) and developmental signaling pathways using chemical and genomic tools.

Yagi Lab

Informatics and digital imaging management

Yajnik Lab

My principal interest is to understand the molecular basis of cancer progression.

Young Laboratory - Anne B. Young, MD

Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms.

Zou Lab

Research topics include: DNA damage response; DNA damage checkpoint; checkpoint signaling; checkpoint activation; genomic instability

Zukerberg Lab

We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in nude mice.

Biostatistics Unit

The Biostatistics Center maintains a combined research and collaborative program that focuses on the development and application of quantitative methods relevant to cancer.

Cancer Pharmacology Core

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.

Cardiovascular Imaging Core Lab

The Cardiovascular Imaging Core Lab at Massachusetts General Hospital is an independent facility dedicated to providing the highest quality services to the cardiovascular imaging community.

CBRC Cores

Overview of CBRC Cores. Please follow the link below for the main MGH Cores page

Center for Computational Discovery

The Center for Computational Discovery (CCD) uses computational, bioinformatic, and statistical approaches to analyze complex biological datasets for basic discovery, translational, and clinical research.

Center for Molecular Therapeutics

The Center for Molecular Therapeutics is actively investigating better ways to match individual cancer patients with particular targeted drug therapies in order to maximize the likelihood of a clinical response.

Center for Outcomes Research

Our research focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

Circulating Tumor Cell Center

The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

Circulating Tumor Cell Center

The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

Functional Genomics

Genome-wide RNAi libraries available at the Broad Institute

hESC Core Facility

The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.

Histopathology Research Core

The Histopathology Research Core provides standard and customized research specific histology services including routine formalin fixation and paraffin embedding, and sectioning and preparation of frozen sections

HSCI-CRM Flow Cytometry Core Facility

Offers custom-built instrumentation for cell sorting and data analysis.

Humanized Mouse Model of HIV Infection

This program investigates HIV pathogenesis and evaluates anti-HIV preventive and therapeutic interventions, in an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.

Institute for Healthcare Policy

The Institute for Health Policy (IHP) is dedicated to conducting world-class research on the leading health issues.

Intravital Microscopy Lab

The CIID Intravital Microscopy Lab is dedicated to the dynamic visualization of cellular processes in vivo in small animals using multiphoton excitation fluorescence microscopy.

Light Microscopy and Image Analysis Core

Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.

Massachusetts General Hospital Imaging Trials Center (MITC)

The Massachusetts General Hospital Imaging Trials Center (MITC) is an Academic Research Organization (ARO) that enhances clinical imaging research by providing scientific and informatics expertise to foster, design, conduct, and support clinical trials.

Metabolomics and Proteomics

A targeted liquid chromatography-mass spectrometry-based metabolomics platform in collaboration with the Broad Institute.

MGH Tissue Repository

The goal of the Massachusetts General Hospital Tissue Repository is to collect human tumor surgical specimens for distribution to researchers in the Massachusetts General Hospitals scientific community, and to the broader biomedical science community as well. Tumor specimens are now available for distribution to researchers.

Molecular Profiling Laboratory

The Molecular Profiling Laboratory (MPL) is one of the Cancer Center research centers that provide technological support to Cancer Center investigators.

Mood & Anxiety Disorders Institute (MADI)

The Center translates the latest research advances into practical information to help people work with their doctors toward the most accurate diagnosis and best possible treatment results.

Mouse Behavior Facility at MIND

We provide Neurology investigators with a wide array of behavioral tasks for comprehensive assessment of motor and cognitive functions, anxiety, and social interactions in mice.

Mouse Models

The Luster lab has expertise in mouse models of disease and in the generation of genetically modified knockout, transgenic and reporter mice to study immune cell function in vivo.

Musculoskeletal Imaging Research Core (MIRC)

The Musculoskeletal Imaging Research Core (MIRC) provides Mass General and Partners investigators with streamlined access to research imaging.

Neurogenetics DNA Diagnostic Laboratory

The Neurogenetics DNA Diagnostic Laboratory at Massachusetts General Hospital conducts standard-setting molecular DNA diagnostic testing for over 25 rare neurodegenerative disorders.

Palliative Care

The Palliative Care Service, in conjunction with the Harvard Medical School Center for Palliative Care, continues to focus research on innovative projects to promote education in end-of life care for health care professionals.

Pathology Imaging Research Core

The Pathology Imaging Research Core provides professional and technical imaging services to researchers at MGH, academic researchers outside the Harvard system, and investigators in Industry

PET Core Laboratory

The PET (positron emission tomography) Core Laboratory provides a full range of technical and professional services for the design and execution of programs using PET.

Phase I Clinical Trials Program

Basic research is necessary to achieve an understanding of the normal and pathological state, but cannot, by itself, put new knowledge to useful applications. The bridge to application is created by the development of diagnostic tests, new drugs or treatment approaches that allow an intervention in patients.

Recombinant Protein Expression and Purification Core

The Recombinant Protein Expression and Purification (RPrEP) Core in the Transplantation Biology Research Center at Massachusetts General Hospital provides cost-effective resources for expression and purification of recombinant proteins necessary for preclinical and basic mechanistic studies by immunologists and cancer biologists.

Specialized Histopathology Services

Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research.

Tetramer Resource Lab

The Tetramer Resource Lab generates fluorescently labeled peptide:MHC multimers for the purpose of detecting polyclonal populations of antigen-specific T cells.

The Analytical and Quantitative Cytology Core Facility

The Analytical and Quantitative Cytology Core Facility offers services and equipment to perform most flow cytometric assays.

The Genomics of Drug Sensitivity (GDS)

Anti-cancer drugs are screened against a large collection (>1000) cancer cell lines representative of many different malignancies to discover links between genotypes and drug response.

Tissue MicroArray Core Lab

The Tissue MicroArray Core in Mass General Hospital Pathology offers tissue array services and technical support in preparing cores.

Tobacco Research and Treatment Center

The Tobacco Research and Treatment Center's clinical research aims to identify effective tobacco treatment strategies and adapt them for the smokers who come to the health care setting.

Translational Research Laboratory

A laboratory dedicated to fostering personalized cancer patient care, through development and implementation of innovative tumor genotyping technologies and collaborative clinical and translational research studies.

Tumor Imaging Metrics

The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal radiological measurements to evaluate therapeutic response for DF/HCC clinical trials.

Tumor Imaging Metrics Core (TIMC)

The Tumor Imaging Metrics Core (TIMC) provides standardized, consistent, and efficient radiological measurements to evaluate tumor response for DF/HCC (Dana-Farber /Harvard Cancer Center) clinical trials.

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