Research Centers

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  • Analytic and Translational Genetics Unit

    The Analytic and Translational Genetics Unit at Massachusetts General Hospital focuses on the interpretation of genome data to aide in the discovery of human disease.

  • Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research

    The Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research at Massachusetts General Hospital is a collaborative of scientists, oncologists, surgeons, radiation oncologists and interventional endoscopists whose mission is to extend and improve the lives of patients with pancreatic cancer.

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  • Cardiovascular Research Center

    The Cardiovascular Research Center (CVRC) at Massachusetts General Hospital was founded in 1990 to bridge the gap between the science of heart disease and the practice of cardiovascular medicine.

  • CCIB

    The Massachusetts General Hospital Center for Computational and Integrative Biology is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard.

  • Center for Assessment Technology and Continuous Health

    CATCH is discovering new health measurements and tools to better diagnose and treat diseases within a patient’s daily life.

  • Center for Cancer Research

    Massachusetts General Hospital Cancer Center is committed to eradicating cancer and is fueled by scientific investigation conducted as part of the largest hospital-based research program in the United States.

  • Center for Engineering in Medicine

    We are the ambassadors of bioengineering, bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.

  • Center for Human Genetic Research

    The Massachusetts General Hospital Center for Human Genetic Research is a multidisciplinary crossdepartmental center with the central mission of facilitating the genetic research cycle.

  • Center for Integration of Medicine & Innovative Technology

    A non-profit consortium of Boston's leading teaching hospitals and universities, the Center for Integration of Medicine & Innovative Technology (CIMIT) fosters interdisciplinary collaboration among world-class experts in translational research, medicine, science and engineering, in concert with industry, foundations and government, to rapidly improve patient care.

  • Center for Regenerative Medicine

    The Center for Regenerative Medicine is dedicated to understanding how tissues are formed and may be repaired in settings of injury and disease.

  • Center for Systems Biology

    The goal of the Massachusetts General Hospital Center for Systems Biology is to analyze, at a systems level, how biological molecules, proteins and cells interact in both healthy and diseased states.

  • Center for the Study of IBD

    CSIBD is a Research Center focused on IBD-oriented research at Massachusetts General Hospital and affiliated institutions sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

  • Center for Translational Pain Research

    The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic, and cancer pain conditions by using a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.

  • Center for Transplantation Sciences

    The Center for Transplantation Sciences is a multidisciplinary research center working at the interface between basic science and clinical applications in transplantation immunology at Mass General.

  • Clinical Research Center

    Clinical Research Center conducts clinical research, including the use of specialized analyses and procedures for approved studies.

  • Codman Center for Clinical Effectiveness in Surgery

    The Codman Center for Clinical Effectiveness in Surgery is is an academic and service program established by the Department of Surgery to encourage and support surgical outcomes research at Mass General.

  • Collaborative Center for XDP

    An international consortium of scientists, physicians and advocates working to advance research and clinical care for people with X-linked Dystonia Parkinsonism

  • Cutaneous Biology Research Center

    To achieve that goal the CBRC maintains an environment conducive to collaboration with industrial partners to disseminate the fruits of fundamental research from the CBRC.

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  • Medical Practice Evaluation Center

    An interdivisional center dedicated to improving clinical outcomes—particularly in HIV/AIDS ad tuberculosis—increasing value in health policy and informing global health through research and education.

  • MIND / Neurology Research

    MassGeneral Institute for Neurodegenerative Disease (MIND)

    The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people living with neurodegenerative disease.

  • Mongan Institute Health Policy Center

    The Mongan Institute Health Policy Center provides solutions to critical challenges in health policy, access, and health care delivery through innovation and research.

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  • Neurological Clinical Research Institute

    The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

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  • Vaccine & Immunotherapy Center

    The Vaccine & Immunotherapy Center (VIC) at Massachusetts General Hospital was established to speed the translation of laboratory discoveries into new, cost-effective therapies and treatments to prevent and cure various forms of cancer and infectious diseases.

  • Vincent Center for Reproductive Biology

    The Vincent Center for Reproductive Biology consists of basic and clinical scientists whose primary research emphasis includes infertility, aging and cancer as they pertain to the ovary and uterus. The center provides an optimal environment for individuals who are interested in integrating clinical and basic sciences and have a strong desire to pursue a career in academic research.

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  • Wellman Center for Photomedicine

    The Wellman Center for Photomedicine at Massachusetts General Hospital investigates the effects of light on human biology and develops light-mediated, minimally invasive diagnostic and therapeutic technologies.

Research Labs

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  • 3D Imaging Lab

    3D Imaging Lab

    The 3D Imaging Lab at Massachusetts General Hospital produces 3D images that provide precise, anatomical visualizations to enhance patient care.

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  • Advanced Tissue Resource Center (ATRC)

    Tissue Nanoarray

    The Advanced Tissue Resource Center in the Department of Neurology at Massachusetts General Hospital serves as a molecular and anatomic neuropathology resource for the Boston neuroscience community. Our research incorporates advanced micro-molecular profiling technologies into studies of human neurodegenerative and psychiatric diseases.

  • Advancing Understanding of Mechanisms of Hepatitis-Related Liver Disease (Chung Laboratory)

    Raymond Chung

    Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C virus, persist in the liver and cause liver damage. Our projects will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.nonresponders or ineligible to receive current treatments.

  • Akito Nakagawa, PhD

    Akito Nakagawa, PhD

    Akito Nakagawa researches the identification of small molecules that modulate gas binding properties of human hemoglobin at Massachusetts General Hospital.

  • Albers Lab at MIND - Mark W. Albers

    Mark W. Albers, MD, PhD

    The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.

  • Alessandrini Laboratory

    Alessandro Alessandrini, PhD

    The Alessandrini Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies regulatory T cells and plasmacytoid dendritic cells, and the roles they play in the induction of transplantation tolerance.

  • Alexander G. Marneros, M.D., Ph.D.

    Alexander G. Marneros

    Alexander G. Marneros, MD/PhD Assistant Professor, Department of Dermatology, Harvard Medical School Dermatology Attending, Massachusetts General Hospital

  • Allan Goldstein Lab

    Allan Goldstein, MD

    My laboratory is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility.

  • Allen Steere, MD

    Photo of Allen Steere, MD

    The Steere Laboratory at Massachusetts General Hospital does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity, and to develop diagnostic tests.

  • Allergy Clinical Research Unit

    The Allergy Clinical Research Unit conducts clinical "translational" research and drug trials of allergic and immunologic diseases, including asthma, chronic rhinosinusitis, nasal polyopsis, drug allergy, hereditary angioedema (HAE) and food allergy.

  • Andrew D. Luster, MD, PhD

    Photo of Andrew D. Luster

    The Luster Laboratory at Massachusetts General Hospital investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

  • Andrew Tager, MD

    Photo of Dr. Andrew Tager

    The Tager Laboratory at Massachusetts General Hospital investigates (1) pulmonary and dermal fibrosis, focusing on the roles lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), and (2) HIV immunopathogenesis, using a novel mouse model of HIV infection.

  • Anesthesia Center for Critical Care Research

    The Anesthesia Center for Critical Care Research (ACCCR) at Massachusetts General Hospital aims to develop novel, paradigm-changing therapeutic strategies to improve outcomes in critically ill patients.

  • Anna Mandinova, M.D., Ph.D.

    Anna Mandinova, M.D., Ph.D. Principal Investigator Biologist (Dermatology) Massachusetts General Hospital

  • ARDS Network Clinical Coordinating Center

    David Schoenfeld, PhD

    The Acute Respiratory Distress Syndrome (ARDS) Network Clinical Coordinating Center coordinates randomized controlled trials for patients with ARDS.

  • Areej El-Jawahri, MD

    Areej El-Jawahri, MD

    Research Interests: Investigating patient-reported outcomes, developing interventions to enhance patient-centered decision-making, and designing supportive and palliative care interventions to improve the care of patients with hematologic malignancies and their families.

  • Arnaout Laboratory

    The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

  • Aryee Lab

    Martin J. Aryee

    Martin J. Aryee, PhD, is a developer of computational methods for genomics and epigenomics. He is a member of the Molecular Pathology Research Unit of Massachusetts General Hospital.

  • Athinoula A. Martinos Center for Biomedical Imaging

    The Martinos Center is committed to developing novel techniques for imaging biological systems and biologically relevant materials, toward a more comprehensive understanding and better care of the human mind and body.

  • Aylwin Ng

    Integrative systems biology of microbial sensing, autophagy, innate immune regulation and programming.

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  • Babitt Laboratory

    The Jodie L. Babitt Lab is focused on elucidating the molecular and cellular mechanisms involved in iron homeostasis

  • Bacskai Lab at MIND

    FLIM plaque

    Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.

  • Bardeesy Lab

    Nabeel M. Bardeesy PhD

    Research topics include: pancreatic ductal adenocarcinoma

  • Benes Lab

    Research topics include: the response to cancer therapeutics, the molecular basis of sensitivity to specific drugs and how to identify the genetic variations affecting the response to targeted therapies

  • Benichou Laboratory

    Gilles Benichou, PhD, DSc

    The Benichou Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies the immune mechanisms underlying the allorecognition and alloresponse by T and B cells in transplant rejection and tolerance.

  • Benjamin Medoff, MD

    Photo of Benjamin Medoff, MD

    The Medoff Laboratory at Massachusetts General Hospital studies the pathogenesis of pulmonary inflammation, specifically the role of T cells in mediating inflammatory lung diseases.

  • Berezovska Lab - Presenilin Group Alzheimer Research Unit

    Oksana Berezovska FLIM shows PS1 distribution in different conformation states

    The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.

  • Bernards Lab

    Bernards

    Research topics include: Neurofibromatosis-1 (NF1)

  • Bernstein Lab

    Bradley Bernstein, MD, PhD

    The Bradley Bernstein pathology research lab at Massachusetts General Hospital applies high-throughput, sequencing-based technologies to characterize chromatin structure genome-wide in human and mouse.

  • Bhan Lab

    Dr. Bhan's research laboratory is focused on defining the pathogenesis of chronic intestinal inflammation. He is widely published and recognized for his expertise.

  • Bhan Laboratory

    The Ishir Bhan Laboratory's research focuses on vitamin D and the immune system in humans, particularly in the setting of renal disease.

  • Bianchi Sleep Informatics Laboratory

    Sleep Informatics Laboratory

    Dr. Bianchi's Sleep Informatics Laboratory focuses on understanding human sleep, in health and disease, through a combination of diverse analytical methods and novel device technology.

  • Bin Zheng, Ph.D

    Our lab studies metabolic signaling in skin diseases, particular in melanoma.

  • Binglan Yu, PhD

    Binglan Yu researches blood transfusion and blood substitutes with the goal of making transfusion of human blood stored for prolonged periods a safer clinical process.

  • Biochemical Translational Imaging - Hooker Research Lab

    Biochemical Translational Imaging - Hooker Research Lab

    The Hooker Research Group, part of the Athinoula A. Martinos Center for Biomedical Imaging, focuses on the development and application of in vivo molecular imaging tools.

  • Bioengineering Laboratory

    Bioengineering Laboratory at MassGeneral Hospital

    The Bioengineering Laboratory continues its tradition of innovation in the area of joint engineering and biomechanics.

  • Biorepository for Neurological Injury

    The Massachusetts General Hospital Biorepository for Neurological Injury advances research in brain health and recovery by providing data to help researchers understand how genes and other factors contribute to risk of brain disease, recovery from brain injuries and the maintenance of a healthy brain.

  • Birrer Lab

    Michael J. Birrer, MD, PhD

    Research topics include: molecular biology of gynecologic cancer; novel therapeutics; genomics of ovarian cancer; clinical trial design; early detection technologies.

  • Body Dysmorphic Disorder Clinic & Research Unit

    The Research Unit currently focuses on studies regarding the treatment of BDD as well as the factors that contribute to the development and maintenance of BDD.

  • Boland Lab -- Genevieve M. Boland, MD, PhD

    The Boland Lab focuses on blood-based techniques for assessing changes in the tumor microenvironment through analysis of circulating exosomes.

  • Bone Marrow Transplant Clinical Research

    The clinical mission of the Bone Marrow Transplant Clinical Research Lab is to provide a comprehensive range of transplant-related services to patients with hematologic malignancies and other potentially life-threatening blood dyscrasias. Its research mission is to develop novel methods of allogeneic stem cell transplantation to maximize the separation of graft versus host disease (GVHD) and graft versus tumor (GVT) effect in both the HLA-matched and mismatched settings.

  • Boucher Lab

    As part of the Edwin L. Steele Laboratory for Tumor Biology, the Boucher Laboratory analyzes delivery of oncolytic viruses and large therapeutic agents in tumors and tumor cell migration and metastasis.

  • Bouley Laboratory

    The Richard Bouley Laboratory is studying the role of vasopressin receptor type 2 in the pathophysiology of diseases associated with water reabsorption dysregulation.

  • Bragg Laboratory -- Chemical Neurobiology of Hereditary Dystonia

    Bragg Laboratory

    The laboratory combines gene expression profiling and chemical screening of novel cellular models to understand the pathogenesis of hereditary dystonias.

  • Brain Trauma Lab

    Brain Trauma Lab

    The Brain Trauma Lab is aimed at learning how to better treat the millions of children with brain trauma and similar problems, now and in the future.

  • Brain Tumor Stem Cell Lab

    Brain Tumor Stem Cell Lab

    The Brain Tumor Stem Cell Lab develops novel therapeutic strategies for glioblastoma through a better understanding of the biological and molecular characteristics of glioblastoma stem cells

  • Brastianos Lab

    Priscilla K. Brastianos, MD

    The Brastianos laboratory studies genomic drivers of human brain tumors.

  • Breakefield Laboratory - Xandra O. Breakefield

    mouse neurons

    The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

  • Breast Cancer Clinical Research

    Our program is on the forefront of investigation to find better therapies, improve diagnostics, and develop less invasive, breast-sparing surgical techniques for the treatment of breast cancer.

  • Breast Imaging Research

    Breast imaging research

    The Breast Imaging Research program is dedicated to improving breast cancer detection and diagnosis in order to reduce the death rate of breast cancer.

  • Breton Laboratory

    The Sylvie Breton laboratory studies the regulation of epithelial cells in the urogenital tract with an emphasis on the kidney and epididymis. Our main areas of interest include: acute kidney injury, chronic kidney disease, male infertility, cystic fibrosis, acid/base homeostasis.

  • Brown Laboratory

    The Dennis Brown Laboratory uses cell biological and imaging techniques to understand mechanisms and physiological signals that regulate the distribution of important proteins in the kidney that regulate urine concentration and systemic acid base balance. We are especially interested in the pathophysiology of vasopressin activated water channels (aquaporins), and in proton pump (V-ATPase) function.

  • Bruce A. Morgan, Ph.D

    Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

  • Brugge Research

    Dr. Brugge

    Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.

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  • Cardiac Anesthesia Lab

    Cardiac Anesthesia Laboratory

    Research within the Cardiac Anesthesia Lab at Massachusetts General Hospital advances the evolving field of cardiac anesthesiology and improves outcomes for both adult and pediatric patients.

  • Cardiac MR PET CT Program

    Cardiac MR PET CT Program

    The Cardiac MR PET CT Program at Massachusetts General Hospital is dedicated to developing, evaluating and assessing novel imaging techniques for cardiovascular conditions.

  • Cardiac Psychiatry Research Program

    The Cardiac Psychiatry Research Program (CPRP) aims to improve the mental health and medical outcomes of patients with heart disease.

  • Cardiac Surgery Lab

    Cardiac surgery research at the Massachusetts General Hospital Corrigan Minehan Heart Center offers patients the most promising therapies based on the latest scientific evidence.

  • Cardiothoracic Transplantation Laboratory

    Joren C. Madsen,  MD, DPhil

    The Cardiothoracic Transplantation Laboratory at Massachusetts General Hospital uses state-of-the-art molecular and cellular techniques to study transplantation tolerance, acute/chronic rejection, innate immunity, xenotransplantation and whole organ bioengineering for heart and lung transplantation models.

  • Cardiovascular Biorepository (CVBio)

    Stored samples at the Cardiovascular Biorepository (CVBio)

    The Massachusetts General Hospital Cardiovascular Biorepository (CVBio) advances cardiovascular research by providing patient data and blood samples to help researchers understand how genes and other factors contribute to heart disease.

  • Cardiovascular Clinical Research Lab

    The Cardiovascular Clinical Research Lab seeks to improve clinical diagnosis and treatment of cardiovascular diseases.

  • Cash, Sydney S., PhD - Cortical Physiology Laboratory

    Cortical oscillations

    We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.

  • Cellular & Molecular Radiation Oncology Laboratory

    Working at the cellular and molecular levels, our studies cover a range of topics, including mechanisms of cell death, DNA damage induction and repair processes, bystander effects, and cancer genetics.

  • Cellular Therapy and Neural Regeneration for Intestinal Neuropathies

    Jaime Belkind-Gerson, MD

    Our overall goal is to continue to characterize neural stem cells and to study their role in ENS regeneration in health and response to disease, as well as using the NSCs as possible cell-therapy for various forms of intestinal neuropathy including Hirschsprung’s disease.

  • Center for Applied Clinical Investigation

    Find out more about the Center for Applied Clinical Investigation (CACI).

  • Center for Computational and Integrative Biology

    The Center for Computational and Integrative Biology provides support for investigators at the hospital and across Boston through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis, microarray analysis, and research laboratory automation.

  • Center for Engineering in Medicine

    We are scientists, engineers and physicians who are bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.

  • Center for Experimental Drugs and Diagnostics

    The MGH Psychiatry Center for Experimental Drugs and Diagnostics (CEDD) focuses on bringing new discoveries in neuroscience and genetics to the clinic.

  • Center for Molecular Imaging Research (CMIR)

    Molecular Imaging Research

    The Center for Molecular Imaging Research (CMIR) at Massachusetts General Hospital and Harvard Medical School researches molecular phenomena to develop novel sensing technologies and, ultimately, clinical applications that can save lives.

  • Center for Rare Neurological Diseases

    Center for Rare Neurological Diseases

    The Mass General Center for Rare Neurological Diseases (CRND) aims to eradicate rare disorders of the nervous system by leveraging the power of biological insights towards design and implementation of clinical trials.

  • Center for Surgery, Innovation & Bioengineering

    Simulated microfluidic cell array

    The Center for Surgery, Innovation & Bioengineering at Massachusetts General Hospital comprises physicians, surgeons, engineers and biologists who create novel, engineering-based biomedical approaches to improve the delivery of health care to patients worldwide.

  • Chan_Research_1375

    Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.

  • Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory

    at the bench

    The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.

  • Cheng Lab

    Leo L. Cheng, PhD

    The research of the Leo L. Cheng lab focuses on human prostate cancer, breast cancer, and lung cancer. The National Cancer Institute sponsors his research.

  • Chung Lab

    Chung

    The overall goal of the Chung Laboratory is to better elucidate the genetic events in gastrointestinal tumorigenesis.

  • Chung Lab

    Chung

    The main research interest of the Chung Laboratory has been studies of the biology of hepatitis C virus infection, the leading cause of chronic viral liver disease in the U.S.

  • Clark Lab

    Tim Clark informatics

    MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.

  • Classon Lab

    Research topics include: the role of the pRB pathway and the pRB family of proteins (pRB, p107 and p130) in tumorigenesis

  • Clinical and Translational Epidemiology Unit

    Andrew Chan

    Our mission is to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions in chronic disease.

  • Clinical Investigation in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

    Our research focuses on understanding the pathogenesis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH), the interaction between obstructive sleep apnea (OSA) and NASH, and the influence of NASH on lipid metabolism and cardiovascular risk factors.

  • Clinical Neuroscience and Neuropsychology of Aging Lab

    The Clinical Neuroscience and Neuropsychology of Aging Lab is focused on the study of age-related cognitive and brain changes that may predispose individuals to develop dementia later in life

  • Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag

    Dr. Dienstag Research

    Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

  • Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag Clinical Research

    Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

  • Cobbold Lab

    Mark Cobbold, MRCP, PhD

    The Cobbold laboratory focuses on understanding how the healthy human immune response is able to recognize and target cancerous cells, and when it fails, how it could be strengthened to recognize this endogenous threat.

  • Cole, Andrew J., Epilepsy Clinical Research

    MRI of brain superimposed over pathology slide

    Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.

  • Colvin Lab

    Dr. Colvin's laboratory is primarily focused on the role of T regulatory cells in spontaneous acceptance of renal allografts in mice.

  • Corcoran Lab

    Ryan Corcoran, MD, PhD

    The Corcoran laboratory focuses on developing new and effective therapies for gastrointestinal cancers, such as colorectal and pancreatic cancers, by targeting the specific survival signals that are active in a given patient’s cancer.

  • Cosimi/Kawai Laboratory

    A. Benedict Cosimi, MD, and Tatsuo Kawai, MD, PhD

    The Cosimi/Kawai Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on allograft tolerance induction in nonhuman primates and humans, with the goal of developing safe and reliable tolerance-inducing regimens for clinical transplantation.

  • Cowan Lab

    Modeling Cardiovascular and Metabolic Disease with Human Pluripotent Stem Cells

  • Craniofacial Developmental Biology Laboratory

    Advances in clinical treatment of congenital craniofacial malformations require improved understanding of the developmental genetic basis of facial morphogenesis. Our goal in the Craniofacial Developmental Biology Laboratory is to investigate fundamental genetic regulation of facial development, with a focus on translating basic science discoveries to clinical advances. We perform research on palate development and neural crest cell biology.

  • Critical Care Translational Medicine Group

    Critical Care Translational Medicine Group

    The Critical Care Translational Medicine Group designs, oversees and coordinates international trials in acute respiratory distress syndrome (ARDS) and sepsis.

  • Cusack Laboratory

    James C. Cusack, Jr., MD

    Research topics in the Cusack Laboratory include: molecular targeted therapies for colorectal cancer, melanoma, Merkel cell cancer and carcinomatosis, and improving delivery of surgical cancer care in resource-limited settings.

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  • Da Silva Laboratory

    The Nicolas Da Silva Laboratory focuses on interactions between the immune system and the male reproductive tract, specifically on the importance of macrophages and dendritic cells during sperm maturation and storage.

  • David Christiani, MD, MPH

    David Christiani, MD, MPH

    Molecular Epidemiology of ARDS: Under the direction of David Christiani, MD, MPH, our laboratory examines genetic and environmental factors that may impact the development and progression of acute respiratory distress syndrome (ARDS).

  • Davidson Lab

    Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.

  • Deborah Forst, MD

    Deborah Forst, MD

    Research Interests: Palliative and supportive care for patients with brain and spinal cord tumors.

  • Demehri Lab

    Shadmehr (Shawn) Demehri, M.D., Ph.D.

    The focus of the Demehri laboratory is to determine the role of the immune system in regulating the early stages of cancer development in order to harness its anti-tumor potential for cancer therapy.

  • Demet S. Sulemanji, MD

    Demet S Sulemanji, MD

    Demet S. Sulemanji researches the use ventilation strategies in critically ill patients with a variety of lung diseases.

  • Di Tomaso Lab

    Research topics include: vaascular physiology of neurofibromatosis type 2 tumors

  • Diabetes Research | David Altshuler, MD PhD

    The Alshuler lab focuses on studies of human genome sequence variation as a route to understanding the inherited basis of common human diseases, with a major focus on type 2 diabetes.

  • Diabetes Research Center

    The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.

  • Diabetes Research Center

    For over two decades, the Massachusetts General Hospital Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.

  • Dickerson Lab

    Alzheimer's disease imaging signature

    Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.

  • Dieter Manstein, MD, PhD

    The Manstein lab conducts basic and clinical research related to novel, energy-based procedures in dermatology.

  • Difiglia Laboratory - Cellular Neurobiology

    Marian DiFiglia, PhD

    Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.

  • Dighe Lab

    Dr. Dighe is engaged in research and development of expert system software for pathology interpretations.

  • Division of Global Health

    The Division of Global Health (DGH) at MassGeneral Hospital for Children is led by Division Chief Dr. Patricia Hibberd and includes energetic faculty members and senior research fellows. The Division's primary mission is to build and foster international partnerships for interdisciplinary research, education and service to reduce health disparities and achieve optimal health for children and adolescents in resource-limited settings of the developing world. Our multidisciplinary team of faculty has significant experience working in the global arena, and in mentoring and teaching future leaders in global health.

  • Division of Neurotherapeutics

    Division of Neurotherapeutics

    Our lab focuses on translating neurobiological research into novel treatments for psychiatric disorders such as post traumatic stress disorder, major depressive disorder, eating disorders and obsessive compulsive disorder.

  • Division of Research in Emergency Medicine

    The Division of Research in the Department of Emergency Medicine at Massachusetts General Hospital pursues a highly active research agenda.

  • Donald Bloch, MD

    Photo of Donald Bloch

    The Bloch Laboratory at Massachusetts General Hospital investigates the putative infectious agent or agents that initiate autoimmune disease.

  • Down Syndrome Research Program

    Photo of child

    We provide innovative opportunities for people with Down syndrome to participate in research.

  • Dr. Cosmas Giallourakis

    Cosmas Giallourakis

    Functions of RNA Chemical Modifications (Epitranscriptomes) in Health and Disease

  • Dr. Deanna Nguyen

    We are interested in studying the role of actin regulation in the pathogenesis of inflammatory bowel disease.

  • Dr. Dinesh Patel Arthroscopy Learning Laboratory

    Dr. Dinesh Patel Arthroscopy Learning Laboratory

    The Dr. Dinesh Patel Arthroscopy Learning Laboratory is a state-of-the-art learning lab with multiple arthroscopy learning stations.

  • Dr. Kate Jeffrey - Epigenetic Control of Innate Immunity

    Epigenetics is a general term encompassing any and all mechanisms that govern gene expression patterns without modifying the underlying DNA sequence. We are interested in how “epigenetic” mechanisms such as histone modifying enzymes and non-coding RNA regulate inflammation and antiviral immunity.

  • Drummond Laboratory

    The Iain Drummond Laboratory studies kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying vertebrate kidney cell differentiation, morphogenesis, ciliogenesis, and regeneration.

  • Dryja Lab

    Dr. Dryja is a principal investigator researching ophthalmic pathology, hereditary diseases of the eye, and new therapies for eye disease.

  • Duda Lab

    Research topics include: solid tumor cellular biology; bone marrow-derived cells in tumor angiogenesis and cancer progression.

  • Dyson Lab

    Nicholas Dyson, PhD

    Research topics include: E2F - and pRB-; tumorigenesis

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  • Edwin L. Steele Laboratory for Tumor Biology

    The Edwin L. Steele Laboratory is committed to improving the prevention, detection and treatment of cancer in patients through a better understanding of tumor pathophysiology and host-tumor interactions.

  • Eichler Lab

    Florian Eichler, MD, dorsal root ganglia

    Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.

  • Elizabeth Goodman, MD

    Elizabeth Goodman, MD

    The Goodman lab is dedicated to decreasing the burden of disease, particularly related to obesity, cardiovascular disease and diabetes, among disadvantaged youth, their families and communities.

  • Ellisen Lab

    Ellisen

    Research topics include: P53 and human tumorigenesis; breast cancer

  • Elyse Park, PhD, MPH

    Elyse Park, PhD

    Research Interests: Development and integration of motivational and behavioral intervention treatments, particularly for chronic stress and smoking cessation, into cancer and survivorship care.

  • Emergency Medicine Network

    Emergency Medicine Network

    The Emergency Medicine Network's (EMNet) mission is to advance public health objectives through diverse projects in emergency care, particularly through multicenter clinical research.

  • Emergency Medicine Research Project Inventory

    ED Research Inventory

    The MGH Department of Emergency Medicine is home to many ongoing research projects which include studies on cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.

  • Emergency Medicine Research Project Inventory

    Emergency Medicine Research Project Inventory

    The MGH Department of Emergency Medicine is home to many ongoing research projects which include studies on cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.

  • Emmanuel Buys, PhD

    Emmanuel Buys, PhD

    Emmanuel Buys investigates the role that soluble guanylate cyclase (sGC) plays in the development of both cardiovascular disease and open angle glaucoma, testing sGC-targeted strategies for disease prevention, detection and treatment.

  • Endocrine Cancers Clinical Research

    The Program in Endocrine Malignancies is dedicated to the diagnosis and therapy of benign and malignant tumors of the endocrine glands. The physicians affiliated with this center have expertise in the diagnosis and treatment of benign and malignant tumors of the thyroid, parathyroid, and adrenal glands as well as the tumors of the endocrine pancreas.

  • Endocrine Unit Research

    Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.

  • Endocrine Unit: Bastepe Laboratory

    The Bastepe Laboratory at Massachusetts General Hospital investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.

  • Endocrine Unit: Bergwitz Laboratory

    Endocrine Unit: Bergwitz Laboratory

    Our research focuses on inborn errors of phosphate metabolism and the endocrine regulation of phosphate homeostasis with an emphasis on the metabolic and homeostatic effects of phosphate.

  • Endocrine Unit: Demay Laboratory

    Endocrine Unit: Demay Laboratory

    The Demay Laboratory at Massachusetts General Hospital is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.

  • Endocrine Unit: Divieti Pajevic Laboratory

    Endocrine Unit: Divieti Pajevic Laboratory

    The Divieti-Pajevic Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone metabolism.

  • Endocrine Unit: Kobayashi Laboratory

    Endocrine Unit: Kobayashi Laboratory

    The Kobayashi Laboratory at Massachusetts General Hospital investigates the genetics of skeletal development.

  • Endocrine Unit: Kronenberg Laboratory

    The Kronenberg Laboratory at Massachusetts General Hospital uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.

  • Endocrine Unit: Mannstadt Laboratory

    Endocrine Unit: Mannstadt Laboratory

    Research in the Mannstadt Laboratory at Massachusetts General Hospital focuses on diseases of the parathyroid glands and mineral metabolism.

  • Endocrine Unit: Shimada Laboratory

    Endocrine Unit: Shimada Laboratory

    The Shimada Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone development and remodeling.

  • Engelman Lab

    Engelman

    Research topics include: lung cancer; targeted therapies; molecular fingerprinting; sensitivity and resistance to targeted therapies, PI3K signaling pathways and EGFR inhibitors in cancer.

  • Ethan A. Lerner, M.D., Ph.D.

    Ethan A. Lerner, M.D., Ph.D.

    Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

  • Eyal Y. Kimchi, MD, PhD -- Delirium Lab

    The Delirium Lab at Massachusetts General Hospital is committed to determining the causes and treatments of delirium through a combination of translational and clinical research.

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  • Fernandez-Del Castillo Lab

    The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

  • Fisher Lab

    Our group studies cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy as well as prevention of melanoma and other human cancers

  • Flaherty Lab

    Functional Magnetic Resonance Image

    Alice W. Flaherty, MD, PhD has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.

  • Frosch Lab

    The Frosch laboratory is interested in the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.

  • Fuchs Lab

    Bryan Fuchs

    The Fuchs Lab researches prevention and treatment strategies for liver fibrosis and liver cancer as well as development of noninvasive techniques for imaging liver fibrosis.

  • Fukumura Lab

    Research topics include: nitric oxide; angiogenesis; tumor microcirculation; intravital microscopy; tumor microenvironment

  • Functional Neurology Research Group

    Functional Neurology Research Group

    The Functional Neurology Research Group at Massachusetts General Hospital, led by David Perez, MD, aims to identify biomarkers of disease, prognosis and treatment response for Functional Neurological Disorders.

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  • Galloway Lab

    Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

  • Garkavtsev Lab

    Research topics include: mechanisms governing the development of brain tumors

  • Gastrointestinal Cancers Clinical Research

    The Tucker Gosnell Center for Gastrointestinal Cancers is the first center of excellence in the Harvard system that focuses on integrated multidisciplinary care and research for hepatic and biliary malignancies.

  • Geijsen Lab

    My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.

  • General Academic Pediatrics

    The Division of General Academic Pediatrics is an internationally-known academic research division dedicated to improving the health of children and adolescents.

  • Genetic Engineering Laboratory

    Robert J. Hawley, PhD

    The Genetic Engineering Laboratory in the Center for Transplantation Sciences (CTS) focuses on understanding the immune response to porcine xenografts, engineering swine for use as solid organ xenotransplantation donors and developing porcine stem cells for use in large animal models of potential stem cell therapies.

  • Genetics Program

    Genetics Program

    The Schizophrenia Program is involved in a wide range of genetic research projects in collaboration with genetic laboratories at Harvard Medical School and other institutions.

  • Genitourinary Cancers Clinical Research

    The clinical research program of the Claire and John Bertucci Center for Genitourinary Cancers is a multidisciplinary effort to understand cancer biology, discover novel agents and improve treatment outcomes for patients with genitourinary malignancies including cancers of the prostate, bladder and kidney.

  • Gerontology Research

    The Geriatric Neurobehavioral Clinic at Massachusetts General Hospital offers a multidisciplinary and individualized approach to the diagnosis of persons with memory disorders.

  • GI Cancers - Daniel C. Chung Laboratory

    Dr. Daniel Chung

    Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.

  • Gian Paolo Dotto, M.D., Ph.D.

    Gian Paolo Dotto, M.D., Ph.D.

    G. Paolo, Dotto, MD, PhD Professor Massachusetts General Hospital Cutaneous Biology Research Center Building 149, 13th Street Charlestown, MA 02129 Tel: (617) 724-9538 Fax: (617) 726-9572 Email: gdotto@partners.org

  • Gilbertson Lab

    John R. Gilbertson, MD

    Gilbertson lab develops information systems and robots to support diagnostic laboratories, diagnostic processes and communications from the lab to the clinicians, researchers and patients.

  • Giselle K. Perez, PhD

    Giselle K. Perez, PhD

    Research Interests: Development of integrative mind-body and behavioral interventions to promote health behavior change, treatment adherence, and treatment outcomes for patients throughout the cancer spectrum.

  • Giselle Perez, PhD

    Research Interests: Development of integrative mind-body and behavioral interventions to promote health behavior change, treatment adherence, and treatment outcomes for patients throughout the cancer spectrum.

  • Global Neurology Research Group

    Baby with cap

    The Global Neurology Research Group, part of the Department of Neurology and the Neurological Clinical Research Institute, finds innovative solutions to improve the quality of neurological care in low- and middle- income countries.

  • Gomez-Isla Lab

    APOE and PRNP

    Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

  • Gomperts Lab

    Lewy body dementia brain scan

    The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

  • Grabowski Lab

    Research topics include: endothelial cell function; imaging platelet thrombosis; blood rheology and thrombosis; hemolytic uremic syndrome

  • Graubert Lab

    Tim Graubert, MD

    The Graubert laboratory focuses on the molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.

  • Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab

    Angiopathy.org logo

    Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

  • Grewo Lim, PhD

    Grewo Lim researches the effect of gene expression on the behavioral interaction between pain and opioid tolerance, exploring the potential use of opioid therapy in chronic pain management.

  • Gynecologic Cancer Clinical Research

    The Center for Gynecologic Oncology has become one of the nation's outstanding centers for clinical research in gynecologic malignancy. The center has had a strong leadership role at every level of development of therapies for women's cancers, from preclinical drug development, to Phase I and II trials, to Phase III cooperative clinical trials.

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  • Haas Lab

    Wilhelm Haas, PhD

    The Haas laboratory uses quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells in a comprehensive proteome-wide manner.

  • Haber Lab

    Haber

    Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer

  • Hacohen Lab

    Nir Hacohen, PhD

    The Hacohen lab consists of immunologists, geneticists, biochemists, technologists and computational biologists working together to develop new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.

  • Hand Surgery Clinical Research

    Hand Surgery Clinical Research Unit

    One of the most productive clinical research units in hand surgery, we address all aspects of recovery from hand and arm injury and illness.

  • Harris Orthopaedics Lab

    Harris Orthopaedics Lab

    The Harris Orthopaedics Lab comprises preclinical biomechanical research and biomaterials testing along with clinical research involving in vivo follow-up of implant performance.

  • Hart Lab

    Research topics include: modeling neurodegenerative disease in C. elegans; notch signaling in the adult nervous system; osmotic stress response and aging; quiescence and sensory signaling; lipid homeostasis

  • Harvard Orthopedic Trauma Research Division

    Harvard Orthopedic Trauma Research Division

    The Harvard Orthopedic Trauma Research Division is an inter-institutional, multi-disciplinary team dedicated to understanding the human biological and clinical processes associated with traumatic orthopedic injuries.

  • Harvard Program in Refugee Trauma

    The Harvard Program in Refugee Trauma has spent 25 years caring for the health and mental needs of survivors of mass violence and torture through a combined practice of clinical experience and medical research.

  • Head & Neck Cancers Clinical Research

    The Center for Head and Neck Cancers is a longstanding multidisciplinary clinical and scientific program that arose from a foundation established by world-renowned clinicians at Massachusetts General Hospital (MGH) and the Massachusetts Eye & Ear Infirmary (MEEI).

  • Healthy Lifestyles Program

    Healthy Lifestyles Program

    At the Healthy Lifestyles Program, people with schizophrenia receive state-of-the-art intervention for weight loss, diabetes prevention, cardiovascular fitness, and improved overall health.

  • Held Lab

    Research topics include: apoptosis; DNA damage and repair; oxidative stress; radiation-induced bystander effects; heavy ion radiation biology

  • Hematologic Malignancies Clinical Research

    The Hematologic Malignancies Program encompasses research regarding leukemia, lymphoma and multiple myeloma, incorporating a substantial commitment to the understanding and use of stem cells in these diseases. It is closely integrated with the Bone Marrow Transplant Program, sharing commitment, faculty and research efforts.

  • Hematopoietic Cell Transplantation Laboratory

    Christene A. Huang, PhD

    The Hematopoietic Cell Transplantation Laboratory in the Center for Transplantation Sciences (CTS) studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.

  • Hersch Laboratory, Steven M. Hersh, MD, PhD

    Hersch Laboratory

    Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.

  • Higgins Lab

    Dr. Higgins studies the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes, and how they change over time.

  • Hochedlinger Lab

    Hochedlinger

    Research topics include: pluripotency and nuclear reprogramming

  • Hochedlinger Lab

    Our lab tries to understand the role stem cells play in normal development and disease.

  • Hock Lab

    Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.

  • Hock Lab

    Hock

    Research topics include: transcription factors in blood development and leukemia

  • Hoggatt Lab

    Jonathan G. Hoggatt, PhD

    The Hoggatt Laboratory is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages, and that have a specific interest in translational science for bone marrow transplantation and other treatments.

  • Hoggatt Laboratory

    Hoggat Laboratory

    The Hoggatt Laboratory focuses on stem cell biology and the development of novel therapies for cancer and tissue regeneration.

  • Huajun Feng, PhD

    The Feng Laboratory at Mass General studies the modulation of ion channels by general anesthetics using molecular biology, biochemistry andelectrophysiology techniques. The laboratory also researches the mechanism and treatment of epilepsy and seizures as well as their related complications.

  • Huang Lab

    Research topics include: spontaneous tumors and their isograft models; histopathology; pathophysiology

  • Hughes Lab

    Kevin S. Hughes, MD

    The Hughes Lab develops a cancer risk assessment software (Hughes riskApps™) that focuses on increasing the quality and efficiency of care while decreasing cost.

  • Hyman Lab

    F11 synapse rescue with treatment b a hz Courtesy of Tara Spires-Jones and Brad Hyman

    The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

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  • Iafrate Lab

    A. John Iafrate, MD, PhD

    The Iafrate laboratory is succeeding in bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.

  • Iliopoulos Lab

    Iliopoulos

    Research topics include; biology of tumor suppressor genes and tumor angiogenesis

  • Immunobiology Laboratory

    Denise Faustman and Lab Members

    The Massachusetts General Hospital Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.

  • Informing the management of gastrointestinal cancers and diseases using simulation modeling - Dr. Chin Hur

    Chin Hur

    Our research focuses on applying outcomes methodologies to the clinical field of gastroenterology. Specific examples include the use of decision-analytic modeling to perform comparative effectiveness research regarding the screening and management of various gastrointestinal cancers and diseases.

  • Inga Lennes, MD, MPH, MBA

    Inga Lennes, MD, MPH, MBA

    Research Interests: Outcomes related to supportive care of cancer patients and measuring the quality of oncology care.

  • Institute for Innovation in Imaging

    The mission of the Institute is to accelerate the clinical translation of novel diagnostic tools for early disease detection and monitoring of emergent treatments.

  • Institute for Technology Assessment (ITA)

    The Institute conducts health outcomes research to guide the development, evaluation and utilization of medical technologies that improve the quality and cost-effectiveness of medical care.

  • Intervention Clinical Trials Program

    Intervention Clinical Trials Program

    The Intervention Clinical Trials Program research team seeks better medication options to treat schizophrenia symptoms and mitigate the medical problems associated with existing medications.

  • Intestinal epithelial cell homeostasis - Mizoguchi Lab

    Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.

  • Intestinal Innate Immunity Group

    Photo of Bobby J. Cherayil, MD

    Experiments carried out by our group are directed at understanding the mechanisms that regulate intestinal innate immune responses to pathogenic and commensal bacteria.

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  • Jain Lab

    Research topics include: tumor microenvironment; angiogenesis and lymphangiogenesis; metastasis; in vivo imaging; translational research; drug delivery, nanotechnology, mathematical modeling

  • James M. Perrin, MD

    James M. Perrin, MD

    The Perrin group studies chronic health conditions in children and adolescents, with particular focus on autism spectrum disorders (ASD). Recent work has examined care improvement for children with ASD and racial and ethnic disparities in autism diagnosis and care. The team also provides evidence to support decision-making regarding newborn genetic screening and has examined recent policy and changes regarding public programs supporting children with disabilities (the Supplemental Security Income [SSI] program).

  • James Moon, PhD

    Photo of Dr. James Moon

    The Moon Laboratory at Massachusetts General Hospital investigates basic issues of CD4+ T cell tolerance by directly tracking endogenous antigen-specific populations in mice and humans.

  • Jamie Stagl, PhD

    Jamie Stagl, PhD

    Research Interests: Psychosocial adaptation to cancer diagnosis and treatment, and evidence-based interventions to improve physical and emotional outcomes and symptom management for patients with cancer and cancer survivors.

  • Jeffrey B. Cooper, PhD

    Jeffrey B. Cooper, PhD

    The Center for Medical Simulation for Medical Simulation advances patient safety by teaching and study of the actions of healthcare providers and educators using simulation. The provider focus is on crises management and teamwork; instructor training focuses on debriefing and development of a learner-centered approach. Research generally studies provider behavior and instructional methods.

  • Jeffrey Peppercorn, MD, MPH

    Jeffrey Peppercorn, MD, MPH

    Research Interests: Issues related to quality of care and survivorship for patients with breast cancer as well as health policy and bioethics issues related to oncology.

  • Jennifer Temel, MD

    Jennifer Temel, MD

    Research Interests: Palliative care, symptom management, and patient-clinician communication.

  • Jenny W. Rudolph, PhD

    Jenny W. Rudolph, PhD

    The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. We also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.

  • Jesse Roberts Jr. Laboratory

    Jesse David Roberts, Jr., MD

    The Roberts Laboratory is devoted to investigating novel mechanisms and developing new therapies for important pediatric lung diseases.

  • Jin Mo Park , Ph.D.

    Assistant Professor of Dermatology Harvard Medical School Assistant Biologist (Dermatology) Massachusetts General Hospital

  • Joseph El Khoury, MD

    Photo of Joseph El Khoury, MD

    The El Khoury Laboratory at Massachusetts General Hospital investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.

  • Joseph Greer, PhD

    Joseph Greer, PhD

    Research Interests: Development and testing of supportive care interventions for patients with cancer.

  • Joung Laboratory

    J. Keith Joung, MD, PhD

    The Joung laboratory utilizes engineered zinc finger, transcription activator-like effector (TALE), and RNA-guided CRISPR/Cas-based systems to create sequence expression alterations in living cells and organisms.

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  • Kaplan Lab

    Lee Kaplan

    At the MGH Weight Center, we believe that treatments for obesity that are safe and effective will be discovered only through ongoing research to find the answers to these and other questions.

  • Katia Georgopoulos, Ph.D.

    Katia Georgopoulos, Ph.D.

    Katia Georgopoulos, Ph.D. Professor of Dermatology Harvard Medical School Biologist (Dermatology) Massachusetts General Hospital

  • Kazantsev Drug Discovery Lab

    aggregate inhibition and promotion inclusion formation - small molecule inhibitors

    The Kazantsev lab is focused on discovering therapeutic agents for Huntington's and Parkinson's diseases using high throughput screening, rational drug design, and medicinal chemistry lead optimization.

  • Keith W. Miller, MA, D Phil, AM

    Keith W. Miller, MA, PhD, AM

    The Miller laboratory focuses on elucidating the molecular mechanisms by which general anesthetics act to produce anesthesia and its side effects.

  • Kelly Irwin, MD

    Kelly Irwin, MD

    Research Interests: Understanding health disparities for individuals with severe mental illness.

  • Kim/Markmann Laboratory

    James I. Kim, PhD

    The Kim/Markmann Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital examines the hypothesis that a small subset of B cells plays a beneficial or regulatory role in transplant tolerance within the elderly population.

  • Kovacs Lab, Neurobiology of Disease Laboratory at MIND

    Confocal images of enriched cultures expressing Navβ2 wildtype

    Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

  • Kristin White, Ph.D.

    Kristin White, Ph.D.

    Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital

  • Kuter Lab

    Research topics include: thrombopoietin; thrombocythemia

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  • Laboratory for Lipid Medicine and Technology

    Laboratory for Lipid Medicine and Technology

    The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.

  • Laboratory for Musculoskeletal Tissue Engineering

    Laboratory for Musculoskeletal Tissue Engineering

    The mission of the Laboratory for Musculoskeletal Tissue Engineering is to conduct cutting edge research in tissue engineering and regenerative medicine for repairing and regenerating musculoskeletal tissues. Programs have been developed in three primary areas: 1) articular cartilage repair and regeneration; 2) meniscal repair and replacement; and 3) photochemical tissue bonding to promote healing.

  • Laboratory for NeuroImaging of Coma and Consciousness

    Institute for NeuroImaging of Coma and Consciousness

    Dr. Brian Edlow’s Laboratory for NeuroImaging of Coma and Consciousness (NICC) aims to improve acute care and long-term outcomes for patients with coma and other disorders of consciousness caused by traumatic brain injury.

  • Laboratory of Computer Science

    Laboratory of Computer Science

    The Laboratory of Computer Science at Massachusetts General Hospital—the Clinical and Research Informatics Division of the Department of Medicine—explores innovative applications of clinical technology in health care.

  • Laboratory of Gastrointestinal Epithelial Biology

    Laboratory of Gastrointestinal Epithelial Biology

    The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota.

  • Laboratory of Molecular Endocrinology

    Laboratory of Molecular Endocrinology

    The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.

  • Lamont Lab

    Research topics include: clinical epidemiology and health services research in cancer

  • Langenau Lab

    David M. Langenau, PhD

    The Langenau research lab seeks to uncover mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.

  • Lara Traeger, PhD

    Research Interests: Behavioral aspects of symptom management and quality of life among adults with cancer.

  • Lara Traeger, PhD

    Lara Traeger, PhD

    Research Interests: Behavioral aspects of symptom management and quality of life among adults with cancer.

  • Lauer Laboratory – Immunology of Viral Infections in Humans

    Dr. Lauer

    Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.

  • Lin Laboratory

    The Herbert Lin Laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease.

  • Lipid Metabolism

    Lipid Metabolism

    Lipid Metabolism research activities center on cholesterol trafficking in and out of cells and the proteins that control this movement.

  • Louis Lab

    David N. Louis, MD

    David N. Louis' research interests include glioma, glioblastoma, molecular genetics, molecular pathology and therapeutics.

  • Lu Laboratory

    The main focus in the Hua Lu Laboratory is to study the mechanism of the trafficking of a water channel protein, AQP2.

  • Lubitz Lab

    Carrie C. Lubitz, MD, MPH

    The Lubitz Lab focuses on improving the quality of care for patients with thyroid, parathyroid and adrenal disorders.

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  • Madhusmita Misra, MD

    Madhusmita Misra, MD

    The Misra group studies neuroendocrine and bone alterations in conditions spanning the nutritional spectrum.

  • Maheswaran Lab

    Maheswaran

    Research topics in the Maheswaran Lab include: tumorigenesis, breast cancer and cancer genetics.

  • Masao Kaneki, MD, PhD

    Masao Kaneki, MD, PhD

    Masao Kaneki, MD, PhD investigates clinical data to help develop new strategies to improve the clinical outcome of critically ill patients with conditions such as sepsis or burn injuries, and chronic inflammation-mediated human diseases such as diabetes.

  • Mass General Imaging Global Health Programs

    Mass General Imaging Global Health Programs

    Mass General Imaging's Global Health Programs are dedicated to addressing unmet medical imaging needs and healthcare disparities for vulnerable and crisis-affected populations.

  • MassGeneral Institute for Neurodegenerative Disease (MIND)

    The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.

  • Maus Lab

    Marcela V. Maus, MD, PhD

    The goal of the Maus lab is to design and evaluate next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.

  • McClatchey Lab

    McClatchey

    Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity

  • Medoff Lung Immunology Laboratory

    The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury.

  • Melanoma Clinical Research

    The Center for Melanoma draws upon the specialized expertise of physicians and researchers from the Departments of Dermatology and Radiation Oncology, and the Divisions of Surgical Oncology, Transplant Surgery, Hematology and Oncology, and Dermatopathology.

  • Membrane Biology Lab

    Membrane Biology Lab

    Membrane proteins play critical roles in the brain. The Membrane Biology Lab studies ATP-hydrolyzing enzymes that control sodium, potassium and calcium movements. Molecular, cellular and biochemical approaches are used to study structure, function and physiology. Mutations found in human diseases, such as dystonia, are being studied in mutant mice.

  • Mental Health and the Media

    The mission of the Center for Mental Health and Media is to destigmatize mental illness, comfort and educate families about optimal development, and to change the public's outdated and inaccurate perceptions of the nature, causes and treatment of mental illness.

  • MGH Nuclear Medicine and Molecular Imaging (NMMI)

    Research areas are organized into three Centers of excellence: PET Radiochemistry Discovery (CPRD); Advanced Radiological Sciences (CARS); and Translational Nuclear Medicine and Molecular Imaging (CTNMI).

  • Michaelson Lab

    Research in the Michaelson Lab focuses on development of databases on several cancers, testing systems and various analyses.

  • MingMing Ning MD, MMSc, Clinical Proteomics Research Center

    From bench to bedside, our center works to find biomarkers from proteomics mass spect data

    The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.

  • Moir Lab

    Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

  • Molecular Biology Laboratory

    Christian LeGuern, PhD

    The Molecular Biology Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.

  • Molecular Neurosurgery Lab

    Molecular Neurosurgery Lab

    Research in the Molecular Neurosurgery Lab focuses on the use of herpes simplex virus (HSV) vectors for cancer therapy and gene delivery in the nervous system, with the long-term goal being the therapeutic application of these vectors to patients.

  • Monoclonal Antibody & Immunotherapy Laboratory

    Monoclonal Antibody & Immunotherapy Laboratory

    The goal of this laboratory is to investigate the role of immunological events in the pathogenesis of orthopedic malignancies and to develop combinatorial immunotherapeutic strategies for the treatment of orthopedic malignancies with special emphasis on translational research.

  • Mostoslavsky Lab

    Mostoslavsky

    Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair

  • Motamedi Lab

    Motamedi

    Research topics include: RNA-mediated epigenetic gene silencing.

  • Moura, Lidia M. V. R., MD, MPH - NeuroValue Health Services Research Lab

    Dr. Lidia Moura

    We use established health services research methods to identify and compare alternative delivery models for achieving desired outcomes. We have a particular interest in strategies for reducing costs while improving the quality of care. The ultimate mission of our group is to design and implement coordinated care models for neurological care of high value.

  • Mucosal Immunology, Microbial Defense and Inflammatory Bowel Diseases - Reinecker Laboratory

    Reinecker

    We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.

  • Mucosal Inflammation Group

    Bryan Hurley

    Our focus is to better understand inflammatory processes impacting mucosal surfaces, particularly in the lung and digestive tract.

  • Multiple Sclerosis (MS) Imaging Laboratory

    MS Imaging Lab

    The Multiple Sclerosis (MS) Imaging Laboratory in the Department of Neurology at Massachusetts General Hospital, led by Eric Klawiter, MD, Msc, is focused on developing new imaging techniques to better understand, diagnose and treat multiple sclerosis.

  • Munn Lab

    Research topics include: leukocyte mechanics and tumor physiology

  • Murat Bastepe, MD, PhD

    Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.

  • Musculoskeletal Genetics and Regenerative Biology Laboratory (MGRBL)

    Musculoskeletal Genetics and Regenerative Biology Laboratory (MGRBL)

    The MGBRL is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

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  • Naar Lab

    Naar

    Research topics include: molecular mechanisms of gene regulation; the function of co-activators and co-repressors in mediating the action of transcription regulators

  • Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory

    The Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory develops innovative minimally invasive techniques using the body’s natural orifices to perform surgeries.

  • Neural Prosthetic Lab

    Neural Prosthetic Lab

    The Neural Prosthetic Lab seeks to improve the effectiveness of CNS-based neural prosthetics by understanding how and why neurons respond to electric stimulation. We use this knowledge to develop improved methods of stimulation. Projects focus on retinal prosthetics, DBS and other devices.

  • Neuro-Oncology Clinical Research

    The Stephen E. and Catherine Pappas Center for Neuro-Oncology is a national leader in clinical research and the development of experimental therapeutics for adult malignant brain tumors.

  • Neurochemistry Laboratory

    Successfully studying novel chemotherapeutic agents for clinical trials in Alzheimer patients.

  • Neuroendocrine Clinical Research Program

    Neuroendocrine Clinical Research Program

    Learn more about clinical research in the Neuroendocrine Unit at Massachusetts General Hospital.

  • Neuroendocrine Malignancies Clinical Research

    The Neuroendocrine Center is one of the premier multidisciplinary clinical and research programs in neuroendocrinology and pituitary tumors in the USA. A recognized international referral center, the Neuroendocrine Center incorporates multidisciplinary expertise from Neuroendocrinology, Neurosurgery, Neurology, Radiation Oncology and Psychiatry.

  • Neuroendocrine Research Laboratory

    Neuroendocrine Research Laboratory

    Learn more about basic research the the Neuroendocrine Unit at Massachusetts General Hospital.

  • Neuroenteric Research Laboratory - Dr. Braden Kuo

    Braden Kuo

    The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.

  • Neuroimaging Program

    Neuroimaging Lab

    The Schizophrenia Program Neuroimaging Investigators use MRI and other imaging technologies to conduct cutting-edge research on the neurobiological basis of schizophrenia.

  • Neurological Clinical Research Institute

    Neurological Clinical Research Institute

    The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

  • Neurology of Vision Lab

    brain activity network mapping

    Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

  • Neuronal Communication and Restoration Lab

    Neuronal Communication and Restoration Lab

    The Neuronal Communication and Restoration Lab probes the mechanisms by which individual neurons communicate locally and across cortical areas, and investigate new approaches for reconstituting the line of communication across areas disrupted within the CNS.

  • Neuroscience Center

    Neuroscience Center

    With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.

  • Neurotherapeutics

    The MGH Neurotherapeutics Program encompasses the clinical, research and training activities related to device-based treatments for psychiatric disorders.

  • NMR Surgical Laboratory

    The Mass General Nuclear Magnetic Resonance Surgical Laboratory investigates biomedical problems related to mechanisms underlying significant medical paradigms, including neoplasia, injury, inflammation, infection and stroke rehabilitation.

  • Nwamaka Eneanya, MD, MPH

    Research Interests: Palliative care, informed decision-making, and racial disparities within the chronic kidney disease population.

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  • Optical Coherence Tomography (OCT) Registry

    OCT Imaging

    Massachusetts General Hospital researchers are spearheading an international effort to study optical coherence tomography (OCT), an imaging technology that could help doctors identify the vulnerable coronary plaques that cause heart attacks or sudden cardiac death.

  • Organ Transplantation Tolerance & Xenotransplantation Laboratory

    Kazuhiko Yamada, MD, PhD

    The Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Center for Transplantation Sciences (CTS) works to develop strategies to induce tolerance across allogeneic and xenogeneic barriers to prevent rejection and relieve the current shortage of donor organs.

  • Orthopaedic Digital Communications Group

    Orthopaedic Digital Communications Group

    The Orthopaedic Digital Communications Group is a multi-disciplinary team working to develop patient education materials.

  • Outcomes Research Center

    Research at the Outcomes Research Center at Massachusetts General Hospital focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

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  • Padera Lab

    Research topics include: the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis

  • Pancreatic Biology Research Laboratory

    The focus of the basic and translational laboratory efforts is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic disease and cancer, specifically the contribution of developmental genes.

  • Pathology Research Center - Molecular Pathology Unit

    Basic and translational research with an emphasis on cancer biology

  • Patient Oriented Research in the Epidemiology of Skin Diseases (PORES)

    Our unit conducts clinical and epidemiologic research related to skin diseases including research on the causes, prevention, evaluation and management of interventions for skin diseases in human populations.

  • Patricio A. Leyton, MD

    Patricio Leyton researches how mutations in bone morphogenetic proteins can result in the development of Primary Pulmonary Arterial Hypertension (PAH).

  • Patrick L. Purdon, PhD

    Patrick L. Purdon, PhD

    Patrick Purdon develops and applies novel methods in neuroimaging and biomedical signal processing to study the systems neuroscience of general anesthesia and other altered states of consciousness.

  • Paunescu Laboratory

    The Teodor Paunescu Laboratory studies proton secretion in the kidney and the olfactory epithelium, and its relevance for maintaining body acid-base balance, the sense of smell, and nutrition.

  • Pediatric Airway, Swallowing and Voice Center

    The Pediatric Airway, Swallowing and Voice Center, a collaboration of MassGeneral Hospital for Children and the Massachusetts Eye and Ear Infirmary, specializes in conducting research to treat children with voice disorders and airway management symptoms that affect the ability to eat, breathe or speak.

  • Pediatric Cancer Clinical Research

    The Center for Pediatric Hematology and Oncology is actively participating in clinical trials and translational research. A significant number of our clinical trials are through collaborative efforts with the Children's Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), the New England Retinoblastoma Group and the Hodgkin Lymphoma Consortium.

  • Pediatric Endocrine-Neuroendocrine-Sports Endocrine Research

    Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further medical knowledge about common endocrine issues in athletes and girls with low-weight eating disorders. In particular, we focus our efforts on establishing findings that lead to the adaptation and improvement of medical care for female athletes and young girls and women with eating disorders.

  • Pediatric Endocrinology Research Lab

    The goal of our laboratory research is to find ways to generate regulated insulin secretion in cells or tissues for pancreatic b-cell replacement therapy in diabetes.

  • Pediatric Epilepsy Research Lab: Kevin J. Staley, MD

    GABA block

    The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.

  • Pediatric Radiation Oncology Clinical Research

    The mission of the Pediatric Radiation Oncology Research program is to continuously improve cancer treatment and outcomes in our pediatric patients through innovative and collaborative research that we translate into clinical care.

  • Pediatric Surgical Research Laboratories

    The Pediatric Surgical Research Laboratories focus on areas of Developmental Biology which hold promise for clinical application for birth defects and cancer prevention and treatment.

  • Peng Laboratory --The Relationship of Host Lipid Metabolism to Hepatitis C Infection

    We have discovered that the cholesterol biosynthetic pathway is critically important to the hepatitis C viral lifecycle and are examining this relationship further.

  • Peterson Lab

    Peterson

    The Peterson laboratory focuses on discovering bioactive small molecules by high-throughput in vivo screening.

  • Physics Research for Radiation Oncology

    Research efforts are focused on developing radiation treatment techniques to optimize physical dose conformation to the tumor target volume and to increase the precision of the dose application.

  • Pillai Lab

    Pillai

    Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia

  • Plastic Surgery Research Laboratory

    Plastic Surgery Research Laboratory at Mass General

    The Plastic Surgery Research Laboratory conducts investigations into tissue engineering of cartilage, mechanisms of neural injury and regeneration, ischemia/reperfusion injury, and transplantation of vascularized limb tissues.

  • Preffer Lab

    The Preffer Lab is focused on the zinc finger transcriptional repressor Gfi-1b, and cytometry data analysis methods in relation to bone marrow.

  • Primary Sclerosing Cholangitis (PSC) Registry -- Daniel S. Pratt, MD

    The PSC Registry at Massachusetts General Hospital is a database and tissue repository established to be a resource for clinical and basic science investigators studying primary sclerosing cholangitis.

  • Program in Membrane Biology

    Program in Membrane Biology

    The MGH Program in Membrane Biology brings together a diverse group of investigators with a common interest in understanding how physiological signals regulate tissue and organ function at the cellular level.

  • Psychiatric & Neurodevelopmental Genetics Unit Core Lab

    Director: Smoller, Jordan, M.D., Sc.D.

  • Psychiatric Neuroscience: Epidemiology Research

    Epidemiology provides a public health perspective on mental health and mental illness in that it is concerned with psychiatric disorders in the general population.

  • Psychiatric Oncology

    In a collaboration between the Department of Psychiatry, consistently rated the best program in the US, and the Mass General Cancer Center, ranked among the top ten in the nation, we are able to complement the research on cancer treatments by focusing on the psychological and behavioral aspects of cancer.

  • Psychological Evaluation and Research Laboratory (PEaRL)

    The Psychological Evaluation and Research Laboratory (PEaRL) is a clinical assessment, research, and training service directed by Mark A. Blais, PsyD, Associate Chief of Psychology at Massachusetts General Hospital (MGH).

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  • QPID (Queriable Patient Inference Dossier) Informatics

    QPID members

    The QPID (Queriable Patient Inference Dossier) Informatics group includes physicians and computer scientists who are developing a novel platform capable of extracting useful patterns of electronic health record data from clinical data repositories.

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  • Radiation Oncology Biostatistics & Biomathematics

    The Division of Biostatistics & Biomathematics supports research-oriented databases and data management needs for Radiation Oncology.

  • Radiochemistry Program - Vasdev Lab

    MGH Radiochemistry - Vasdev Lab

    The Radiochemistry Program - Vasdev Lab at Massachusetts General Hospital is dedicated to discovering new chemistry and evaluating novel PET radiopharmaceuticals for preclinical and clinical imaging studies.

  • Rajagopal Lab

    Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system, in part due to the abundance of respiratory diseases of unknown causes and without cures. Visit our lab website at http://www.rajagopallab.com

  • Raje Lab

    Research topics include: multiple myeloma; tumor microenvironment; bone disease and myeloma; novel therapies for multiple myeloma

  • Ramaswamy Lab

    Ramaswamy

    Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.

  • Ramaswamy Lab

    Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.

  • Research at the Center for Cancer Risk Assessment

    Ellisen

    Research at the Center for Cancer Risk Assessment (CCRA) is devoted to advancing all aspects of cancer risk assessment, screening and prevention. The Center has both laboratory and clinical components.

  • Research in Inflammatory Bowel Diseases - Dr. Ashwin Ananthakrishnan

    My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.

  • Rhee Laboratory

    The Eugene Rhee Laboratory is interested in several aspects of renal metabolism, with the goal to understand how alterations in energy metabolism contribute to kidney disease pathogenesis and its complications and to discover metabolite markers of CKD and its progression.

  • Rheumatology Clinical Research Unit

    The Rheumatology Clinical Research Unit at Massachusetts General Hospital performs state-of-the-art translational research for patients with immune-mediated and rheumatological conditions.

  • Riccardo Barbieri, PhD

    Riccardo Barbieri

    Riccardo Barbieri analyzes biological systems such as the cardiovascular, central nervous and automatic nervous systems through mathematical modeling, providing a more accurate and noninvasive assessment of these systems.

  • Richa Saxena, PhD

    Richa Saxena

    Richa Saxena studies the genetics of circadian rhythms/sleep disorders and their association with common disease like type 2 diabetes. The lab also investigates the genetics of preeclampsia, and its role in predicting the risk of future cardiovascular disease.

  • Rivera Lab

    Miguel N. Rivera, MD

    Our laboratory uses genomic technologies to identify and characterize pathways implicated in pediatric solid tumors and sarcomas.

  • Robert Anthony, PhD

    Photo of Robert Anthony

    The Anthony Laboratory at Massachusetts General Hospital investigates the interplay of inflammation and glycosylation, with the intention of engineering and fine tune responses.

  • Robert E. Gerszten, MD

    Photo of Robert Gerszten, MD

    The Gerszten Laboratory at Massachusetts General Hospital investigates the molecular basis of injury responses in cardiovascular disease.

  • Robert Simon, EdD

    The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. The lab also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.

  • Rosenberg Lab

    The Rosenberg Lab focuses on the immunology and pathogenesis of HIV infection. We study CD4+ T helper cells in persons with acute HIV and long-term non-progressive infection.

  • Ryan Nipp, MD

    Ryan Nipp, MD

    Research Interests: Geriatric oncology, palliative care and health services research.

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  • Sadri-Vakili Neuroepigenetics Laboratory

    Huntington disease pathogenic mechanisms

    The laboratory focuses on identifying epigenetic alterations that regulate gene expression in brain disorders, and investigates whether these alterations are heritable across multiple generations.

  • Sahay Lab

    Our goals are to understand how plasticity mechanisms in the adult brain may be harnessed to modify hippocampal functions in cognition and mood and how alterations in neural circuits contribute to the development of psychiatric disorders. As part of this endeavor, the laboratory has two main areas of focus.

  • Sam W. Lee, Ph.D

    Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Research Center Professor MGH/Harvard Medical School

  • Sarcoma Molecular Biology Laboratory

    The Sarcoma Molecular Biology Laboratory conducts studies on molecular biology of sarcoma and mechanisms of multidrug resistance

  • Sarcomas & Soft Tissue Tumors Clinical Research

    The Center for Sarcoma and Connective Tissue Oncology offers a truly multidisciplinary approach to care, including research and clinical trials conducted as part of one of the largest hospital-based programs in the nation.

  • Scadden Lab

    The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.

  • Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology

    I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.

  • Schmidt Lab

    Research topics include: Cyclin D1

  • Schwarzschild Lab - Molecular Neurobiology Laboratory

    adenosine molecule fragment

    The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.

  • Scott Harris, MD

    Scott Harris, MD

    The Harris Lab is a multi-disciplinary, inter-departmental group of investigators aiming to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling and bioengineering. In our studies, we apply rigorous quantitative tools to investigate the complex structure-function relationships of healthy and diseased lungs.

  • Sensorimotor Integration Lab

    Sensorimotor Integration Lab

    The Sensorimotor Integration Lab explores the influence of basal ganglia in adaptive learning and motor control in subjects undergoing surgery for movement disorders, such as Parkinson’s disease, while awake.

  • Sever Laboratory

    The Sanja Sever Laboratory's research focuses on podocyte structure and function, the large regulatory GTPase dynamin, as well as the intersection of these two areas.

  • Sgroi Lab

    Dennis C. Sgroi, MD

    My laboratory is currently focused on applying high-throughput DNA microarray and proteomic technologies as a means to predict the clinical behavior of human breast cancer in the setting of specific hormonal and chemotherapeutic regimens.

  • Shawn Demehri, MD, PhD

    Shawn Demehri, MD, PhD

    Principal Investigator, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School

  • Shioda Lab

    Shioda

    Research topics include: signaling of mammary epithelial cells

  • Shoulder Biomotion Laboratory (SBL)

    Shoulder Biomotion Laboratory

    The Shoulder Biomotion Lab conducts studies on shoulder joint biomechanics and upper extremity nerve pathology. Our mission is to bridge basic science research with clinical applications to advance shoulder joint treatments.

  • Skeletal Biology Research Center

    The Skeletal Biology Research Center of the Department of Oral and Maxillofacial Surgery does pioneering work to apply advances is biomedical engineering, biomechanics, tissue engineering, and computer-aided surgical planning to the art of reconstruction or congenital and acquired facial deformities.

  • Smith Lab

    Dr. Smith's research focuses primarily on immunology and transplantation, with emphasis on the transplantation pathology of the heart, kidney, and pancreatic islets.

  • Smoking Cessation Program: Center for Addiction Medicine and Schizophrenia Program

    Smoking Cessation

    At the Mass General Smoking Cessation Program, people with schizophrenia receive the best in personally tailored behavioral and medication treatment for smoking cessation as well as prevention of relapse to smoking.

  • Smoller Laboratory

    The Smoller Laboratory is working to understand the genetic basis of psychiatric disorders in order to improve diagnosis and treatment.

  • Soberman Laboratory

    The overall focus of the Roy Soberman Laboratory is to understand signal integration and macromolecular organization in cells of the immune system, and how these processes are linked to control the amplification of the immune response.

  • Sports Concussion Clinic Research

    We conduct leading scientific research to better understand concussions in young people and to develop better approaches to assessment, treatment, and rehabilitation.

  • Stem Cell Biology and Cellular Reprogramming Laboratory - Choi Laboratory

    Dr. Choi

    We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.

  • Stem Cell Therapeutics and Imaging Program

    Stem Cell Therapeutics and Imaging Program

    The Stem Cell Therapeutics and Imaging Program focuses on engineering therapeutic and diagnostic stem cells for different pathologies in pre-clinical settings and translating them into clinics.

  • Stemmer-Rachamimov Lab

    The Stemmer-Rachamimov Lab focuses their research on the molecular pathology of hereditary brain tumor syndromes such as NF1, NF2 and schwannomatosis.

  • Stone Lab

    The Stone laboratory is researching signal transduction mechanisms and intimal necrotic/lipid cores in Atherosclerosis.

  • Stroke Service Research

    Stroke Service Research

    Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.

  • Supko Lab

    Research topics include: pharmacokinetic studies of new anticancer agents

  • Suter Pulmonary Optical Imaging Laboratory

    Suter Pulmonary Optical Imaging Laboratory

    The focus of the Pulmonary Optical Imaging Laboratory is the development and subsequent translation of novel optical diagnostic tools for evaluating the pulmonary airways and lung.

  • Suvà Lab

    Mario L. Suvà is an assistant professor of pathology at Massachusetts Hospital, and a Broad Institute-associated scientist. His most recent work is related to glioblastoma tumors.

  • Suva Lab

    Mario Luca Suvà, MD, PhD

    Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.

  • Sweetser Lab

    Sweetster

    Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.

  • Syed Shaukat Husain, PhD

    Syed Shaukat Husain, PhD

    Syed Shaukat Husain studies the molecular composition of general anesthesia.

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  • Tanabe Lab

    Research topics in the Tanabe Lab include: hepatobiliary cancer, Epidermal Growth Factor and hepatocellular carcinoma.

  • Tannous Lab - Experimental Therapeutics and Molecular Imaging Laboratory

    Gaussia Princeps

    Bakhos Tannous, PhD – Research focus in molecular Imaging, gene transfer technologies and high throughput screening aiming at finding novel therapeutics against brain tumors.

  • Tanya Keenan, MD, MPH

    Research Interests: Breast cancer disparities and end of life care.

  • Tanzi Lab - Genetics and Aging Research Unit

    A beta forms amyloid fibrils

    Dr. Rudolph Tanzi is carrying out genome-wide association screens to identify novel genes associated with AD and autism spectrum disorders.

  • Tearney Lab

    Dr. Tearney's research is focused on developing and validating non-invasive, high-resolution optical imaging diagnostic methods, such as optical coherence tomography.

  • Technology Implementation Research Center (TIRC)

    Technology Implementation Research Center (TIRC)

    The Technology Implementation Research Center conducts translational research relating to orthopedic implants, materials and surgical technologies. Our mission is to dramatically improve the quality of orthopaedic care by leveraging biomechanical and biomaterials research to bring disruptive technology to active clinical use.

  • Teratology Program

    The Teratology Program focuses on the study of the causes of congenital malformations.

  • Teresa Hagan, PhD, RN

    Teresa Hagan, PhD

    Research Interests: How women with a history of cancer get their needs met in the face of challenges.

  • Terry Means, PhD

    Photo of Dr. Terry Means

    The Means Laboratory at Massachusetts General Hospital combines molecular biology, cellular biology, and genetics to understand the molecular and cellular mechanisms of inflammation and host defense.

  • Test Katia Georgopoulos, Ph.D.

    Katia Georgopoulos, Ph.D. Professor of Dermatology Harvard Medical School Biologist (Dermatology) Massachusetts General Hospital

  • TGF-beta signaling in development and disease Mullen Laboratory

    Understanding how TGF-beta signaling regulates the activity of coding and non-coding genes in health and disease

  • Thadhani Laboratory

    The Ravi Thadhani Laboratory's research efforts are divided into two main areas: Pregnancy and Dialysis. Pregnancy related studies have centered on human studies supporting basic science collaborations in the area of angiogenic factors and preeclampsia. In dialysis, we have conducted studies examining the effect of vitamin D in the survival of chronic hemodialysis patients.

  • The Deborah Kelly Center for Outcomes Research

    The Deborah Kelly Center for Outcomes Research

    The mission of the Deborah Kelly Center is to facilitate exemplary obstetrical and gynecologic outcomes-based research in women's health care.

  • The Laboratory for Tissue Engineering and Organ Fabrication

    The Laboratory for Tissue Engineering and Organ Fabrication is designing and building replacement living tissues and organs to ultimately translate to clinical therapies.

  • The Program in Nutritional Metabolism

    The Program in Nutritional Metabolism

    The Program in Nutritional Metabolism at Massachusetts General Hospital was formed under the direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.

  • The Stott Laboratory

    Shannon Stott, PhD

    Research topics include: Circulating tumor cells; microfludics and control of the cell microenvironment; imaging.

  • Think:Kids Laboratory for the Study of Childhood Behavior Disorders

    Think:Kids logo

    The Laboratory for the Study of Childhood Behavior Disorders, directed by Alisha Pollastri, PhD, uses modern research tools to examine the cognitive, biological and social underpinnings of behavioral challenges during childhood, and the factors that are associated with positive treatment outcomes.

  • Thoracic Cancers Clinical Research

    Lung cancer is the leading cause of cancer-related mortality in the United States. Despite great advances in the understanding of lung cancer biology, only 15% of patients are alive five years after diagnosis. The research program of the Center for Thoracic Cancers is a multifaceted effort designed to understand thoracic cancer biology, discover novel agents and improve treatment.

  • Thorsten R. Mempel, MD, PhD

    Photo of Thorsten Mempel, MD, PhD

    The Mempel Laboratory at Massachusetts General Hospital investigates cell migration and intercellular communction in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.

  • Thyroid Cancer Research Lab

    Image using PET/CT technique showing thyroid cancer

    The main focus of the Mass General Thyroid Cancer Research Laboratory, led by Sareh Parangi, MD, is to study certain key genetic and epigenetic changes seen more frequently in those patients who do poorly, and find out how exactly these genetic changes lead to more aggressive cancer behavior in those patients.

  • Tilo Winkler, PhD

    Tilo Winkler, PhD

    Tilo Winkler studies the effect of bronchoconstriction on regional ventilation to determine how ventilation defects emerge, and identify methods of treatment and prevention. The laboratory also develops new methods for pulmonary imaging and image analysis to improve studies in asthma, COPD, ventilator induced lung injury and other diseases.

  • Ting Lab

    David Ting, MD

    Research Topics Include: Pancreatic ductal adenocarcinoma (PDAC)

  • TRANSCEND Research Laboratory, Martha Herbert, MD, PhD

    TRANSCEND logo

    TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.

  • Translational Brain Tumor Immunology Lab

    Translational Brain Tumor Immunology Lab

    Research in the Translational Brain Tumor Immunology Lab focuses on the development and evaluation of novel therapies for brain tumors.

  • Translational Center Investigating Prescription Drug Abuse (MIDA)

    MIDA is an interdisiplinary collaborative center for the purpose of basic science and clinical research of prescription drug abuse.

  • Transplantation Biology Research Center (TBRC) Laboratories

    David H. Sachs, MD

    The Transplantation Biology Research Center (TBRC) Laboratories in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital comprises two laboratories investigating tolerance induction in transplantation.

  • Trauma Research Laboratory

    Trauma Research Laboratory

    Research at the Trauma Research Laboratory targets critical aspects of early trauma care, focusing on clearly defined high-impact goals.

  • Traumatic Brain Injury Research Laboratory

    Our laboratory focuses on secondary mechanisms of acute brain injury including trauma and intracerebral hemorrhage.

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    Anna Mandinova page Anna Mandinova, M.D., Ph.D. Anna Mandinova, M.D., Ph.D. Principal Investigator Biologist (Dermatology) Massachusetts General Hospital

  • Tsao Lab

    Tsao

    The overall goal of my research effort is to better understand the genetic basis of melanoma formation and the clinical realization of these molecular events.

  • Turka Laboratory

    Laurence A. Turka, MD

    The Turka Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.

  • Type 1 Diabetes Research | Immunobiology Laboratory

    The Mass General Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.

  • Type 2 Diabetes Laboratory

    research

    The Type 2 Diabetes Laboratory at Massachusetts General Hospital focuses on studies relating to insulin resistance in type 2 diabetic patients.

  • Type 2 Diabetes Laboratory Research

    The Diabetes Lab focuses on studies relating to insulin resistance in Diabetic patients.

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  • Vagefi Laboratory

    Parsia A. Vagefi, MD

    The Vagefi Laboratory in the Massachusetts General Hospital Center for Transplantation Sciences (CTS) focuses on developing tolerance-inducing strategies utilizing a preclinical model of pig-to-baboon xenotransplantation.

  • Vascular Biology Research Laboratory

    The Vascular Surgery Research Laboratory is involved in experimental strategies geared towards understanding the pathophysiology of intimal hyperplasia and ischemia reperfusion injury. We are also involved in the development of novel clinically relevant experimental therapies to treat and/or prevent both of these complex problems.

  • Vascularized Composite Allotransplantation Laboratory

    Cetrulo Lab

    The Vascularized Composite Allotransplantation Laboratory in the Massachusetts General Hospital Center for Transplantation Sciences (CTS)investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.

  • Vasudevan Lab

    Vasudevan

    Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence

  • Vicki Jackson, MD, MPH

    Research Interests: Early integrated outpatient palliative care and palliative care communication education.

  • Visual Prosthesis Lab

    Visual Prosthesis Lab

    The Visual Prosthesis Lab is working to create a means to restore sight to the blind by sending signals from a digital camera directly into the brain.

  • Voice Center Research Labs

    Voice Center Research Laboratories

    Mass General's Voice Center Research Laboratories are designed to develop novel technologies, biomaterials, devices, and surgical tools for advancing the diagnosis, management and treatment of laryngeal diseases and pathologies that affect voice.

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  • Wainger Laboratory

    Brian Wainger, MD, PhD

    The Wainger Lab at Massachusetts General Hospital focuses on how abnormalities of motor and sensory neuron physiology contribute to diseases such as ALS and chronic pain.

  • Wang Laboratory

    Zhirui Wang, DVM, PhD

    The Wang Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital uses a unique diphtheria toxin-resistant yeast Pichia Pastoris expression system as a platform to develop novel diphtheria toxin-based recombinant immunotoxins/fusion toxins for specific depletion of targeted cell populations in vivo.

  • Warshaw Lab

    Warshaw

    The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.

  • Wasim Q. Malik, PhD

    Wasim Malik researches and develops technology for healthcare applications with a focus on neuroscience and neuroengineering.

  • Wayne Shreffler, MD, PhD

    Photo of Wayne Shreffler, MD, PhD

    The Shreffler Laboratory at Massachusetts General Hospital is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.

  • Webster Center for Advanced Research and Education in Radiation

    Webster Center - Reducing Dose, Enhancing Benefit

    The Webster Center promotes and develops imaging methods that use the lowest achievable radiological exposure to patients and disseminates those methods through dedicated radiation-dose education programs.

  • Wein Laboratory

    The laboratory of Marc N. Wein, MD, PhD studies osteocytes and how they control bone homeostasis.

  • Wheeler Muscular Dystrophy Research Lab

    wheeler lab

    We study muscular dystrophies with the long-term goal of finding new treatments for patients.

  • Whetstine Lab

    Whetstine

    Research topics include: histone demethylase; chromatin; C. elegans; transcription; epigenetics; JMJC; HDAC

  • Wilbur Lab

    Dr. Wilbur's lab researches endocervical and endometrial glandular lesions in gynecologic cytopathology, computational pathology and translational molecular medicine.

  • Willers Lab

    Research topics include: lung cancer; radiation; EGFR; molecular targeting; DNA repair

  • Williams Laboratory

    The Winfred Williams Laboratory studies the genetic basis of chronic allograft nephropathy.

  • Wojciechowski Laboratory

    The David Wojciechowski Laboratory's clinical research is focused on the prevention and treatment of viral infection post-kidney transplant, improving access to transplantation, and the evaluation of immunosuppressive regimens focusing on novel agents and drug combinations in order to maximize patient and graft outcomes and minimize toxicity.

  • Wu Lab

    The Wu lab aims to identify molecular and genetic changes of urologic cancers. Recent work focuses on prognostic indicators and biomarkers.

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  • Xavier Laboratory

    Dr. Xavier

    The primary research goal of the Xavier Laboratory is to discover and understand the function of important mediators and effectors involved in the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. Current themes of the lab include (1) systems biology of innate and adaptive immunity, (2) functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes, and (3) genetics of Crohn's disease, celiac disease and ulcerative colitis.

  • Xu Lab

    Research topics include: tumor angiogenesis and metastasis; tumor microenvironment

  • Xu Wu, Ph.D.

    My research is focused on studying cellular functions (self-renewal, differentiation, proliferation, and chromatin remodeling) and developmental signaling pathways using chemical and genomic tools.

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  • Yagi Lab

    Dr. Yagi is an internationally recognized expert in whole slide imaging and digital pathology imaging. Her innovative contributions have advanced pathology informatics, telepathology and diagnostic imaging.

  • Yajnik Lab

    Dr. Yajnik

    My principal interest is to understand the molecular basis of cancer progression.

  • Yeh Laboratory

    Heidi Yeh, MD

    The Yeh Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital researches ways to improve access to transplantation and reduce wait list times.

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  • Zou Lab

    Zou

    Research topics include: DNA damage response; DNA damage checkpoint; checkpoint signaling; checkpoint activation; genomic instability

  • Zukerberg Lab

    We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in nude mice.

Resource Labs

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  • Biostatistics Unit

    The Biostatistics Center maintains a combined research and collaborative program that focuses on the development and application of quantitative methods relevant to cancer.

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  • Cancer Pharmacology Core

    The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.

  • Cardiovascular Imaging Core Lab

    Cardiovascular Imaging Core Lab

    The Cardiovascular Imaging Core Lab at Massachusetts General Hospital is an independent facility dedicated to providing the highest quality services to the cardiovascular imaging community.

  • CBRC Cores

    Overview of CBRC Cores. Please follow the link below for the main MGH Cores page

  • CCIB DNA Core

    The CCIB DNA Core at Massachusetts General Hospital is dedicated to providing high-quality research services (molecular biology, genomics and laboratory automation) and access to state-of-the-art instrumentation, methodologies and expertise.

  • Cell Resource Core

    The nonprofit Cell Resource Core at Massachusetts General Hospital provides fresh and cryopreserved hepatocytes for use by researchers at Mass General and other research institutions.

  • Center for Cancer Systems Discovery

    The Center for Cancer Systems Discovery (CSD) uses computational, bioinformatic, and statistical approaches to analyze complex biological datasets for basic discovery, translational, and clinical research.

  • Center for Integrated Diagnostics

    Providing Clinically Actionable Molecular Diagnostics to Accelerate the Adoption of Personalized Medicine

  • Center for Molecular Therapeutics

    The Center for Molecular Therapeutics is actively investigating better ways to match individual cancer patients with particular targeted drug therapies in order to maximize the likelihood of a clinical response.

  • Center for Outcomes Research

    Our research focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.

  • Circulating Tumor Cell Center

    The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

  • Circulating Tumor Cell Center

    ctc-chip, circulating tumor cells

    The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.

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  • Echocardiography Core Laboratory

    The Echocardiography Core Lab at Massachusetts General Hospital provides expert echocardiography readings for public and privately funded clinical trials.

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  • hESC Core Facility

    The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.

  • Histopathology Research Core

    The Histopathology Research Core provides standard and customized research specific histology services including routine formalin fixation and paraffin embedding, and sectioning and preparation of frozen sections

  • HSCI-CRM Flow Cytometry Core Facility

    Offers custom-built instrumentation for cell sorting and data analysis.

  • Humanized Mouse Model of HIV Infection

    This program investigates HIV pathogenesis and evaluates anti-HIV preventive and therapeutic interventions, in an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.

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  • Institute for Healthcare Policy

    The Institute for Health Policy (IHP) is dedicated to conducting world-class research on the leading health issues.

  • Intravital Microscopy Lab

    The CIID Intravital Microscopy Lab is dedicated to the dynamic visualization of cellular processes in vivo in small animals using multiphoton excitation fluorescence microscopy.

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  • Mass General Imaging Trials Center

    Massachusetts General Hospital Imaging Trials Center (MITC)

    The Massachusetts General Hospital Imaging Trials Center is an Academic Research Organization (ARO) that enhances clinical imaging research by providing scientific and informatics expertise to foster, design, conduct, and support clinical trials.

  • MGH Tissue Repository

    The goal of the Massachusetts General Hospital Tissue Repository is to collect human tumor surgical specimens for distribution to researchers in the Massachusetts General Hospitals scientific community, and to the broader biomedical science community as well. Tumor specimens are now available for distribution to researchers.

  • MGH Tissue Repository

    TBD

  • Molecular Profiling Laboratory

    The Molecular Profiling Laboratory (MPL) is one of the Cancer Center research centers that provide technological support to Cancer Center investigators.

  • Mood & Anxiety Disorders Institute (MADI)

    The Center translates the latest research advances into practical information to help people work with their doctors toward the most accurate diagnosis and best possible treatment results.

  • Mouse Behavior Facility at MIND

    We provide Neurology investigators with a wide array of behavioral tasks for comprehensive assessment of motor and cognitive functions, anxiety, and social interactions in mice.

  • Mouse Models

    The Luster Lab has expertise in mouse models of disease and in the generation of genetically modified knockout, transgenic and reporter mice to study immune cell function in vivo.

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  • Neurogenetics DNA Diagnostic Laboratory

    DNA strands illustration for Mass General Neurogenetics DNA Diagnostic Laboratory

    The Neurogenetics DNA Diagnostic Laboratory at Massachusetts General Hospital conducts standard-setting molecular DNA diagnostic testing for over 25 rare neurodegenerative disorders.

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  • Palliative Care

    The Palliative Care Service, in conjunction with the Harvard Medical School Center for Palliative Care, continues to focus research on innovative projects to promote education in end-of life care for health care professionals.

  • Pancreatic Islet Isolation Laboratory

    James F. Markmann MD, PhD

    The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory is a specialized service facility practicing FDA-approved Good Manufacture Procedure (cGMP) standards to manufacture human pancreatic islets.

  • Pathology Clinical Research Testing

    Testing services provided by the former Pathology Clinical Laboratory Research Core changed effective January 16, 2015. Please refer to the Tests and Prices list for more information.

  • Pathology Imaging Research Core

    The Pathology Imaging Research Core provides professional and technical imaging services to researchers at MGH, academic researchers outside the Harvard system, and investigators in Industry

  • PET Core Laboratory

    PET-CT

    The PET (positron emission tomography) Core Laboratory provides a full range of technical and professional services for the design and execution of programs using PET.

  • Phase I Clinical Trials Program

    Basic research is necessary to achieve an understanding of the normal and pathological state, but cannot, by itself, put new knowledge to useful applications. The bridge to application is created by the development of diagnostic tests, new drugs or treatment approaches that allow an intervention in patients.

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  • Radiology Clinical Trials Program

    The Massachusetts General Hospital Department of Radiology's Clinical Trials Program offers contract research organizations, core-imaging labs, biopharmaceutical companies and biotechnology corporations the full spectrum of imaging-related services in support of clinical trials.

  • Radiology Research Administration

    Radiology Research Administration supports basic and clinical research in the Massachusetts General Hospital Department of Radiology by fostering communication and providing guidance regarding funding, regulatory issues, and study management.

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  • Specialized Histopathology Services

    Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research.

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  • Test for Sam W. Lee, Ph.D

    Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Research Center Professor MGH/Harvard Medical School Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Research Center Professor MGH/Harvard Medical School Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Research Center Professor MGH/Harvard Medical School Principal Investigator, Biologist - Massachusetts General Hospital Cutaneous Biology Principal

  • Tetramer Resource Lab

    The Tetramer Resource Lab generates fluorescently labeled peptide:MHC multimers for the purpose of detecting polyclonal populations of antigen-specific T cells.

  • The Analytical and Quantitative Cytology Core Facility

    The Analytical and Quantitative Cytology Core Facility offers services and equipment to perform most flow cytometric assays.

  • The Genomics of Drug Sensitivity (GDS)

    Anti-cancer drugs are screened against a large collection (>1000) cancer cell lines representative of many different malignancies to discover links between genotypes and drug response.

  • Tissue MicroArray Core Lab

    The Tissue MicroArray Core in Mass General Hospital Pathology offers tissue array services and technical support in preparing cores.

  • Tobacco Research and Treatment Center

    The Tobacco Research and Treatment Center's clinical research aims to identify effective tobacco treatment strategies and adapt them for the smokers who come to the health care setting.

  • Translational Research Laboratory

    A laboratory dedicated to fostering personalized cancer patient care, through development and implementation of innovative tumor genotyping technologies and collaborative clinical and translational research studies.

  • Tumor Imaging Metrics

    The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal radiological measurements to evaluate therapeutic response for DF/HCC clinical trials.

  • Tumor Imaging Metrics Core (TIMC)

    Tumor Imaging Metrics Core

    The Tumor Imaging Metrics Core (TIMC) provides standardized, consistent, and efficient radiological measurements to evaluate tumor response for DF/HCC (Dana-Farber /Harvard Cancer Center) clinical trials.

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