Harris Orthopaedics Lab

Harris Orthopaedics Lab

The Harris Orthopaedics Lab comprises preclinical biomechanical research and biomaterials testing along with clinical research involving in vivo follow-up of implant performance.

Overview

The Harris Orthopaedic Laboratory (HOL) has over five decades of experience in addressing problems in adult reconstructive surgery by innovating new surgical techniques, devices, joint implant designs, and joint implant materials. Notably, several formulations of highly cross-linked ultrahigh molecular weight polyethylene (UHMWPE), stabilized by re-melting or vitamin E,weredeveloped for large scale usage in implant manufacturing in this laboratory and havesince changed the landscape of joint replacement by reducing the number of wear particles and instances of osteolysis associated with total joint implants. After about a decade of use, these materials have become the gold standard in joint replacement, especially of the hip.

One focus area of the laboratory today is advancing material development in joint repair and replacement. Under the direction of Orhun K. Muratoglu, PhD, the pre-clinical material research team develops novel UHMWPEs for improving the longevity of joint implants and expanding the use of joint replacement safely to younger and more active patients. Another cutting edge area is the development of non-degradable hydrogel-based materials for integrative and mechanically feasible repair of cartilage defects at an early degenerative state. The materials research team collectively brings experience in material and polymer science, polymer chemistry, biomaterials and biomechanics testing and bench-to-clinic implant development as well as follow-up testing of explanted devices to analyze in vivo effects.

While the HOL has a strong and successful history in joint replacement, our current projects include applying our expertise to other musculoskeletal systems such as the hydrogel-based treatment of degenerative spine conditions and improving the mechanical and integrative properties of bone grafts.

Another major area of focus is follow-up and analysis of clinical implant performance to provide evidence-based feedback to patients and clinicians. Under the direction of Henrik Malchau, MD, PhD, the clinical research team develops local and regional implant registries in collaboration with orthopaedic surgeons in arthroplasty, spine, hand, sports medicine, trauma, and orthopaedic oncology.They also conduct prospective clinical studies nationally and internationally on alternative bearing materials and new implant designs, which provide fast and valuable information on the performance of newly developed implants and helps compare them to historical standards. These studies also can provide feedback on surgical techniques and skills to improve clinical outcomes.

Team

The Harris Lab with the Department of Orthopaedic Surgery, Mass General, Boston

Director

Founder & Director Emeritus

Director Emeritus

Principal Investigators

Lab Manager

  • Slav Lerner

Project Manager

  • Keith K. Wannomae

Support Staff

  • Corey Burns
  • Ann Goodrich

Visiting Orthopaedic Surgeon

  • Inari Laaksonen, MD, PhD

Biomedical Engineers and Technicians

  • Christopher J. Barr
  • David S. Chan
  • Andrew J. Lozynsky
  • Brad R. Micheli
  • Caitlin O'Brien

Clinical Study Coordinators

  • James W Connelly
  • Vince Galea
  • Sean Matuszak

PhD Students

  • Ali Eren Atici
  • Ayse Baker Atici
  • Weishen Chen, MD
  • Jeremy Suhardi

 

Academic CRO

As a full-service Academic Contract Research Organization (ACRO), the Harris Orthopaedics Lab provides comprehensive clinical research services, drawing upon the clinical trial expertise of its Harvard Medical School affiliated academic faculty and Massachusetts General Hospital affiliated professional staff.

Services

  • Study Design
  • Project Management
  • Site Management and Monitoring
    • Assistance with Worldwide Site Selection and Subcontracting
      • US, Australia, S. Africa, UK, Europe
    • Site Payments
    • Recruitment and Follow-up Optimization
  • Data Management using CFR 21 Part 11 Compliant Data Collection and Reporting System
    • Patient Reported Outcome Measures
    • Radiographic Analysis
    • Soft Tissue Imaging Analysis
  • Statistical Analysis
  • Significant Adverse Event Monitoring and Reporting
  • Scientific Manuscript Development and Presentations at International Conferences
  • Data and Safety Monitoring Board (DSMB) Set-up and Coordination

Harris Orthopaedics Lab is associated with a number of Joint Registries in the US, Australia, UK and the Nordic countries, enabling us to limit duplicate data entry, offer improved study site management and communication, as well as follow patient outcomes long-term via the registries.

Academic Program

The ACRO helps sponsor MD/PhD students with an interest in registry science in a visiting Fellowship program designed to develop the students skills in clinical outcomes research and the analysis of large data sets obtained through collaboration with national and regional arthroplasty registries. The fellowships range from six months to one year. During their time in Boston, the students take advantage of the training courses offered by MGH and Harvard University, such as those related to ethics, statistical analysis, proper conduct of human research and leadership development. Educational opportunities include: travel to national and international conferences such as the American Academy of Orthopedic Surgeons and the International Society of Arthroplasty Registries; interaction with leaders in the field of arthroplasty registries; visits to national registry sites and interaction with various registry leaders; participation in data mining and data analysis; abstract and manuscript preparation.

This program is well suited for clinician scientists interested in making the conduct of clinical outcomes studies and registry interaction a part of their career and for those who reside in countries with established or developing national and regional registries. Past participants: Denmark: Karl Tobias Haak MD, PhD; Henrik Palm MD, PhD; Anders Troelsen MD, PhD, Kirill Gromov MD, PhD; Nanna H. Sillesen MD, PhD; Christian Skovgaard Nielsen MD, PhD · Sweden: Ola Rolfson MD, PhD; Viktor Lindgren MD, PhD · Finland: Rami Madanat MD, PhD.

Academic CRO Publications

Innovations

Research Projects

Our research projects are mainly in:

  1. Material and animal model development for arthroplasty and resurfacing
  2. Material and animal model development for focal cartilage defect repair
  3. Biomaterials and biomechanical testing and device development
  4. Clinical evaluation of new implants and materials
  5. Evaluation of new surgical techniques and technology
  6. Evaluation of quality control measures and cost effectiveness analysis
  7. Development and evaluation of methods for measuring performance, wear, stability, etc. from clinical radiographs

Opportunities

Graduate Students

There are no available openings at this time.

Post-Doctoral Fellowships

Post-Doctoral Research Fellow - Anti-Infective Material Strategy

August 17, 2016

The Harris Orthopedic Laboratory (HOL) at MGH specializes in translational research for orthopedic biomaterials and implants. HOL is looking to hire a fulltime post-doctoral research fellow for a 2-year appointment. The laboratory is a focal point in the orthopedic research community for development of new materials and test methods for total joint replacements, which are implanted in over 1 million patients in the US alone each year. This is a great opportunity for scientists looking to apply their basic knowledge in translational research.

Peri-prosthetic osteolysis (resorption of bone around implants causing loosening), a major problem compromising the longevity of joint implants, was drastically reduced over the last decade due to radiation cross-linking of ultrahigh molecular weight polyethylene (UHMWPE) bearings. Our lab has pioneered work in the radiation cross-linking of UHMWPE as well as the incorporation of antioxidants for oxidative stabilization. A major unaddressed problem in joint replacement and in orthopaedic implants in general is implant-associated infections. We are specifically interested in developing technologies that prevent and treat infection in a multi-modal manner using implant materials and implantation algorithms. The post-doctoral fellow will be responsible for (i) formulating methods of triggered release of antimicrobial agents; and (ii) evaluating efficacy and safety of formulations in vitro and in pre-clinical animal models.

We are interested in interviewing candidates with a strong polymer science and materials science background. Experience with general polymer characterization methods, and familiarity with bacterial cultures is preferred.

Degree Requirements:
Ph.D. in Materials Science, Polymer Science, Chemical Engineering, Polymer Chemistry, or equivalent experience with polymers is required.

Location:
Mass General Hospital - Main Campus

Contact Person: Ebru Oral, Ph.D.

Post-Doctoral Research Fellow - High-Temperature Processing Polyethylene

August 17, 2016

The Harris Orthopedic Laboratory (HOL) at MGH specializes in translational research for orthopedic biomaterials and implants. HOL is looking to hire a fulltime post-doctoral research fellow for a 2-year appointment. The laboratory is a focal point in the orthopedic research community for development of new materials and test methods for total joint replacements, which are implanted in over 1 million patients in the US alone each year. This is a great opportunity for scientists looking to apply their basic knowledge in translational research.

Cross-linked ultrahigh molecular weight polyethylene (UHMWPE) is the bearing material of choice in joint replacement implants worldwide due to its high wear resistance. Our lab has pioneered the work in radiation and peroxide cross-linking of UHMWPE as well as the incorporation of antioxidants for oxidative stabilization. One of our long-term goals is improving the fatigue crack initiation resistance, toughness, and strength of cross-linked UHMWPEs to enable more patient-friendly designs and to increase the lifetime and function of implants. High temperature melting (HTM) of crosslinked UHMWPE is one method that improves the ultimate tensile strength and toughness through controlled degradation of the polymeric network and increased diffusion of chains through grain boundaries. We are specifically interested in investigating further this toughening mechanism for chemically cross-linked polyethylene bearing surfaces with HTM. The postdoctoral fellow will be responsible for leading our efforts in (i) understanding the changes in the molecular structure, (ii) crystalline morphology, (iii) macrostructure of the polymer under various cross-linking conditions. The HOL is equipped with all of the necessary processing and analytical tools to carry out this project. In addition, HOL has access to the shared facilities of Harvard University and MIT.

We are interested in interviewing candidates with strong polymer science and materials science background. Experience with general polymer characterization methods, and familiarity with polymer processing is preferred.

Degree Requirements:
Ph.D. in Materials Science, Polymer Science, Chemical Engineering, Polymer Chemistry, or equivalent experience with polymers is required.

Location:
Mass General Hospital - Main Campus

Contact Person: Ebru Oral, Ph.D.

Material Engineering

Biomedical Engineering Position in Translational Research (Entry Level)

September 01, 2016

The Harris Orthopedic Laboratory (HOL) at Massachusetts General Hospital (MGH) is focused on the development of polymeric and hybrid materials in orthopaedics. HOL is seeking a highly motivated individual for an entry level research position to support our translational research program in implantable biomaterial development. This position is ideal for new engineering graduates interested in the medical application of basic research, and is a great opportunity for those who want to gain some experience before continuing their education in graduate or medical school.

With more than 10,000 employees in the greater Boston area, Massachusetts General Hospital (MGH) is a leading employer for healthcare professionals. It is also one of the teaching hospitals for Harvard Medical School and provides the opportunity to train with accredited faculty. For research employees, HOL and MGH offer an academically competitive compensation package including; subsidized medical and prescription coverage; possible educational reimbursement; and so much more!

Responsibilities

Specific technical functions:

  • Laboratory formulation including preparation of polymer blends, polymeric consolidation
  • Modification of polymers including outside services such as radiation processing
  • Characterization of polymers on site and of‐site at available facilities in Boston including mechanical and fatigue testing, wear testing, thermal characterization
  • May include cell culture studies on processed UHMWPE materials including cell passaging, incubation and cell viability analysis using various assays

General laboratory functions:

  • Assembly, operation, maintaining operation protocols, training, scheduling management and some maintenance of assigned equipment
  • Ordering supplies and keeps track of related inventory
  • Maintaining clean equipment, glassware and laboratory space
  • Working alongside other research technologists, MD students, PhD students and post‐doctoral fellows

Administrative/reporting functions:

  • Organizing and accurately maintaining written records of procedures and data
  • Generating and compiling experimental information/results in graphs, charts, and reports
  • Preparing written and/or verbal reports for supervisor and/or senior research personnel
  • Collaborating with supervisor in developing research methodologies and research objectives
  • Collaborating with supervisor in writing and editing material for publication; opportunity for authorship in publications

Qualifications:

  • Must have BS. Non-engineering degrees will ONLY be considered with relevant experience
  • Must have at least one year non‐course based laboratory research experience
  • Coursework and/or internship experience in polymeric materials a plus
  • Coursework and/or laboratory experience with cell culture methods or animals a plus
  • Must have good communication skills and the ability to interact professionally with all levels of staff
  • Must have excellent critical thinking ability and demonstrated problem identification and solving skills. An eye for detail is critical
  • Must have solid, practical skills in Microsoft Office applications. Demonstrated proficiency in Matlab is a plus
  • Must be self‐motivated and able to work independently under supervision

How To Apply: Please send an email with your resume and cover letter in pdf format to Ebru Oral

Clinical Fellowships

There are no available openings at this time.

Undergraduate Internships

There are no available openings at this time.

Publications

2016 Publications

  1. Donahue, G.S., V. Lindgren, V.P. Galea, R. Madanat, O. Muratoglu, H. Malchau; Are Females at Greater Risk for Revision Surgery After Hip Resurfacing Arthroplasty With the Articular Surface Replacement Prosthesis? Clin Orthop Relat Res, 2016. [Pub Med]
  2. Doshi, B., J.S. Ward, E. Oral, O.K. Muratoglu; Fatigue toughness of irradiated vitamin E/UHMWPE blends. J Orthop Res, 2016. [Pub Med]
  3. Greene, M.E., O. Rolfson, M. Gordon, K. Annerbrink, H. Malchau, G. Garellick; Is the use of antidepressants associated with patient-reported outcomes following total hip replacement surgery? Acta Orthop, 2016: p. 1-8. [Pub Med]
  4. Gromov, K., M.E. Greene, J.I. Huddleston, R. Emerson, P. Gebuhr, H. Malchau, A. Troelsen; Acetabular Dysplasia and Surgical Approaches Other Than Direct Anterior Increases Risk for Malpositioning of the Acetabular Component in Total Hip Arthroplasty. J Arthroplasty, 2016. 31(4): p. 835-41. [Pub Med] [PDF]
  5. Hussey, D.K., R. Madanat, G.S. Donahue, O. Rolfson, O.K. Muratoglu, H. Malchau; Worse health-related quality of life and hip function in female patients with elevated chromium levels. Acta Orthop, 2016: p. 1-7. [Pub Med]
  6. Laaksonen, I., G.S. Donahue, R. Madanat, K.T. Makela, H. Malchau; Outcomes of the Recalled Articular Surface Replacement Metal-on-Metal Hip Implant System: A Systematic Review. J Arthroplasty, 2016. [Pub Med] [PDF]
  7. Langlois, J., A. Zaoui, D.A. Bichara, C. Nich, M. Bensidhoum, H. Petite, O.K. Muratoglu, M. Hamadouche; Biological reaction to polyethylene particles in a murine calvarial model is highly influenced by age. J Orthop Res, 2016. 34(4): p. 574-80. [Pub Med]
  8. Madanat, R., D.K. Hussey, G.S. Donahue, H.G. Potter, R. Wallace, C. Bragdon, O. Muratoglu, H. Malchau; Early Lessons From a Worldwide, Multicenter, Follow-up Study of the Recalled Articular Surface Replacement Hip System. Clin Orthop Relat Res, 2016. 474(1): p. 166-74.[Pub Med]
  9. Madanat, R., O. Rolfson, G.S. Donahue, D.K. Hussey, H.G. Potter, R. Wallace, O.K. Muratoglu, H. Malchau; Medial Calcar Erosion Is Associated With Synovial Thickness in Patients With ASR XL Total Hip Arthroplasty. J Arthroplasty, 2016. [Pub Med] [PDF]
  10. Nebergall, A.K., A.A. Freiberg, M.E. Greene, H. Malchau, O. Muratoglu, S. Rowell, T. Zumbrunn, K.M. Varadarajan; Analysis of Dual Mobility Liner Rim Damage Using Retrieved Components and Cadaver Models. J Arthroplasty, 2016. 31(7): p. 1595-602. [Pub Med]
  11. Nebergall, A.K., M.E. Greene, H. Rubash, H. Malchau, A. Troelsen, O. Rolfson; Thirteen-Year Evaluation of Highly Cross-Linked Polyethylene Articulating With Either 28-mm or 36-mm Femoral Heads Using Radiostereometric Analysis and Computerized Tomography. J Arthroplasty, 2016. [Pub Med]
  12. Nebergall, A.K., O. Rolfson, H.E. Rubash, H. Malchau, A. Troelsen, M.E. Greene; Stable Fixation of a Cementless, Proximally Coated, Double Wedged, Double Tapered Femoral Stem in Total Hip Arthroplasty: A 5-Year Radiostereometric Analysis. J Arthroplasty, 2016. 31(6): p. 1267-74. [Pub Med]
  13. Nebergall, A.K., A. Troelsen, H.E. Rubash, H. Malchau, O. Rolfson, M.E. Greene; Five-Year Experience of Vitamin E-Diffused Highly Cross-Linked Polyethylene Wear in Total Hip Arthroplasty Assessed by Radiostereometric Analysis. J Arthroplasty, 2016. 31(6): p. 1251-5. [Pub Med]
  14. Nyholm, A.M., H. Palm, H. Malchau, A. Troelsen, K. Gromov; Lacking evidence for performance of implants used for proximal femoral fractures - A systematic review. Injury, 2016. 47(3): p. 586-94. [Pub Med]
  15. Oral, E., B.N. Doshi, R.M. Gul, A.L. Neils, S. Kayandan, O.K. Muratoglu; Peroxide cross-linked UHMWPE blended with vitamin E. J Biomed Mater Res B Appl Biomater, 2016. [Pub Med]
  16. Oral, E., A.L. Neils, B.N. Doshi, J. Fu, O.K. Muratoglu; Effects of simulated oxidation on the in vitro wear and mechanical properties of irradiated and melted highly crosslinked UHMWPE. J Biomed Mater Res B Appl Biomater, 2016. 104(2): p. 316-22. [Pub Med]
  17. Oral, E., C. O'Brien, B. Doshi, O.K. Muratoglu; High temperature homogenization improves impact toughness of vitamin E-diffused, irradiated UHMWPE. J Orthop Res, 2016. [Pub Med]
  18. Rowell, S.L. O.K. Muratoglu; Investigation of surgically retrieved, vitamin E-stabilized, crosslinked UHMWPE implants after short-term in vivo service. J Biomed Mater Res B Appl Biomater, 2016. 104(6): p. 1132-40. [Pub Med]
  19. Sillesen, N.H., M.E. Greene, A.K. Nebergall, J.I. Huddleston, R. Emerson, P. Gebuhr, A. Troelsen, H. Malchau; 3-year follow-up of a long-term registry-based multicentre study on vitamin E diffused polyethylene in total hip replacement. Hip Int, 2016. 26(1): p. 97-103.[Pub Med]
  20. Timm, T., J. Grabitzki, C. Severcan, S. Muratoglu, L. Ewald, Y. Yilmaz, G. Lochnit; The PCome of Ascaris suum as a model system for intestinal nematodes: identification of phosphorylcholine-substituted proteins and first characterization of the PC-epitope structures. Parasitol Res, 2016. 115(3): p. 1263-74.[Pub Med]
  21. Varadarajan, K.M., T. Zumbrunn, M.P. Duffy, R. Patel, A.A. Freiberg, H.E. Rubash, H. Malchau, O.K. Muratoglu; Reducing the distal profile of dual mobility liners can mitigate soft-tissue impingement and liner entrapment without affecting mechanical performance. J Orthop Res, 2016. 34(5): p. 889-97.[Pub Med]
  22. Langlois J, Zaoui A, Bichara DA, Nich C, Bensidhoum M, Petite H, Muratoglu OK, Hamadouche M; Biological reaction to polyethylene particles in a murine calvarial model is highly influenced by age. Journal Orthopaedic Research, 2016: 34(4), pp 574–80. [Pub Med]
  23. Nebergall AK, Freiberg AA, Greene ME, Malchau H, Muratoglu OK, Rowell S, Zumbrunn T, Varadarajan KM; Analysis of Dual Mobility Liner Rim Damage Using Retrieved Components and Cadaver Models. Journal of Arthroplasty, 2016:31(7), pp 1595-1602. [Pub Med] [PDF]

Contact

Contact Us

Harris Orthopaedics Lab

Jackson Building 1121A55 Fruit Street Boston, MA 02114

MGH's Main Campus:

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