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The major focus of the Laboratory of Gastrointestinal Epithelial Biology is to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia. The small intestine is lined by a simple columnar epithelium in which pluripotent, proliferating crypt cells (stem cells) give rise to four distinct lineages of differentiated cells, including enterocytes (95%), goblet, and enteroendocrine cells on the villi, and paneth cells at the crypt base.
Our various ongoing projects relate to understanding the differentiation process in the contexts of:
Richard A. Hodin, MD
Presently, we are focused on defining the mechanisms that govern gut mucosal defense and the interplay between the host and the intestinal microflora.
We are employing IAP knockout and IAP transgenic mice in order to examine the role of this protein in regard to the gut barrier, and to lay the groundwork for IAP-based therapies that could be used clinically to help patients in the settings of severe trauma, sepsis, critical illness, and in the context of a variety of gut diseases such as IBD.
View a list of publications by researchers at the Laboratory of Gastrointestinal Epithelial Biology
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