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Our research focuses on the role of the calpain small subunit in bone development and remodeling using genetically manipulated mouse models.
Parathyroid hormone (PTH) regulates blood calcium through actions mainly in bones and kidneys. PTH-related peptide (PTHrP), a locally released protein, primarily affects skeletal differentiation and organ development. Both PTH and PTHrP bind to the same receptor.
Calpains are enzymes consisting of a large subunit and a small subunit encoded by the gene Capns1 that cleave to various proteins to modulate their functions in cells. We established direct binding between the intracellular tail of the PTH/PTHrP receptor and the calpain small subunit, that is essential for embryonic survival and regulates calpains’ protease stability and activity.
Using genetically manipulated mouse models, our project has focused on investigating the role of the calpain small subunit in:
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Endocrine Unit Research Laboratories
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