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Research at Mass General
Neurology Access Center
The Neurological Clinical Research Institute (NCRI) was co-founded in 1994 by Dr. Merit Cudkowicz and Dr. Steven Greenberg to conduct clinical research in neurological disorders. The NCRI develops, designs, supports and manages innovative observational and interventional trials for neurological disorders. In collaboration with the Mass General Biostatistics Center, the NCRI has an impressive record of rapidly and efficiently organizing, overseeing, coordinating, and conducting small and large multi-center, international clinical trials including randomized, double-blind, double-dummy and open label designs.
The mission of the NCRI is to accelerate translational research in neurological disorders through initiating and testing novel therapies. The NCRI will fulfill this mission by supporting the entire therapeutic development process, including:· Mapping the clinical development of potential therapies;· Custom design of clinical research protocols; · Bringing efficiency strategies and infrastructure to clinical research;· Providing resources, experienced staff, and services to accelerate the conduct of clinical research;· Fostering and empowering scientific collaboration;· Creating partnerships among scientific leaders with complementary backgrounds;· Establishing and managing disease-specific research consortia;· Performing high quality site-level clinical research;· Educating and mentoring future leaders in the field of clinical research; and· Encouraging scientific innovation through funding.
Northeast ALS Consortium (NEALS)
The NCRI serves as a Coordinating Center for the Northeast ALS Consortium (NEALS), a non-profit, research consortium committed to the cooperative implementation, timely completion, analysis, and reporting of clinical trials and other research studies aimed at improving patient care and understanding of the disease process of Amyotrophic Lateral Sclerosis (ALS). Together with the Barrow Neurological Institute, the two entities have supported 39 clinical research studies in ALS.
Co-founded by Dr. Merit Cudkowicz , the NEALS Consortium was formed with the goal of bringing together leading ALS scientists and clinicians caring for ALS patients, to offer advice on the selection of the best therapies and direction of ALS research. Today there are over 115 membership sites dedicated to ALS research across North America, Israel, Australia, and Ireland.
Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)
The NCRI is the Clinical Coordinating Center for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), a National Institute of Neurological Disorders and Stroke (NINDS) initiative. NeuroNEXT was created to conduct studies of treatments for neurological diseases through partnerships with academia, private foundations, and industry. The network is designed to expand the NINDS capability to test promising new therapies, increase the efficiency of clinical trials before embarking on larger studies, and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders.
The NeuroNEXT program aims to:
For more information: www.neuronext.org
The Mass General Neurological Clinical Research Institute has over 60 staff members dedicated to neurology clinical research.
Merit Cudkowicz, MD, MScNCRI Co-DirectorMassachusetts General Hospital617-726-9122
Steve Greenberg, MD, PhDNCRI Co-DirectorMassachusetts General Hospital
Nazem Atassi, MDNCRI Associate DirectorMassachusetts General Hospital617-643-6114
James Berry, MDNCRI Associate DirectorMassachusetts General Hospital 617-726-5097
Kristin DrakeSenior Director Business Development, Strategic Initiatives, and NCRI Operations
Marianne Kearney ChaseDirector of Research Operations617-726-5893
Darlene Sawicki, NPCo-Director of MGH ALS Multidisciplinary Clinic617-726-6190
Jen ScaliaAssociate Site Director
Kristin SchwabDirector of Clinical Research Operations, Stroke Research Center
Alex ShermanDirector of Systems617-643-2935
Hong Yu, MPHDirector of Data Management617-726-5591
Beverly SmitsOperations and Project Manager
Our Work in ALS
Our staff is dedicated to finding new treatments for ALS. Our team leads and manages clinical trials at major medical institutions throughout the United States and Canada. The Mass General NCRI can also give interested individuals with ALS access to participate in clinical trials of medications and therapies designed to lead to better treatments. Below is a list of our active trials in ALS.
Active Trials in ALS
View Clinical Research Studies
Other WorkThe NCRI also serves as coordinating center for studies initiated by members of the Mass. General Neurology Department. It is the Data Management core for all NIH-funded MGH SPOTRIAS projects as well as for a Parkinson’s disease biomarker study (Dr. Scherzer, PI). The MGH NCRI provides expertise in IND submissions and reporting, trial execution and feasibility and efficiency for various disease populations inclusive of studies in ALS, Multiple Sclerosis, Non-Arteritic Anterior Ischemic Optic Neuropathy, Progressive Supranuclear Palsy, Myasthenia Gravis, and Adrenoleukodystrophy.
We are currently seeking to hire dedicated candidates to join our group. To view detailed job descriptions and application instructions, please visit the MGH Careers page and search for the posting ID number listed after each job title below.
Assistant Project Manager (3013590) Biorepository Inventory Specialist (3017734) Research Access Nurse (3021216) Analysts- Sr. Systems Analyst (3016738) Systems Analyst (3016739) Application Analyst (3016740)Data Management-Clinical Data Manager
ALS Multidiciplinary Clinic Openings:
ALS Clinic Social Worker (3016103)ALS Clinic Physical Therapist (3020201)Clinical Continuity Nurse (3022899)
Please visit the David Glaser Mass General / Project ALS Internship Program page for more information on our internship opportunities.
Please visit the Neurology Education page to find more information and apply for residency, fellowship and observership programs.
Neurological Clinical Research Institute (NCRI)
General Inquiries: NCRIGeneralInquiries@mgh.harvard.edu
Research Inquiries: firstname.lastname@example.org
Clinical Research Staff
Marianne Kearney ChaseDirector of Research OperationsPhone: 617-726-5893E-mail: MKearney4@Partners.org
Beverly SmitsOperations and Project Manager617-643-7723
Patient Appointments & Clinical Office
ALS Multidisciplinary Clinic Phone: 617-724-3914
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