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Research at Mass General
Eric S . Rosenberg, MD
Associate Professor of Pathology, Harvard Medical SchoolPhysician, Massachusetts General HospitalDirector, Clinical Microbiology LaboratoryInfectious Disease Division and Clinical Microbiology Laboratories
Massachusetts General HospitalGray J-52955 Fruit StreetBoston, MA 02114Phone: 617-724-7519Email: firstname.lastname@example.org
In the vast majority of individuals infected with HIV-1, infection is characterized by the inability of the immune system to control viral replication. This failure of containment of HIV-1 replication inevitably results in disease progression. The one notable exception to this observation is in persons with long-term non-progressive infection who appear to contain viral replication in the absence of antiretroviral therapy. My laboratory investigates the mechanisms used by the cellular immune system in these individuals who are successful in mounting effective responses against HIV-1. Recent work has focused on characterizing CD4+ T helper cell function in individuals with long-term non-progressive infection and in a cohort of persons identified with acute HIV-1 infection prior to antibody seroconversion who when treated also generate functionally relevant immune responses. Currently, we are studying immunologic and virologic mechanisms employed by both host and virus that result in success or failure of the host immune response. In particular, we are studying how HIV-specific CD4+T helper cell responses are generated and subsequently disarmed during acute HIV-1 infection. In addition, we are studying the immunologic, virologic and clinical impact of antiretroviral therapy initiated during acute HIV-1 infection. Further investigation into the function of CD4+ T helper cells in these individuals will hopefully provide critical insight into the pathogenesis of HIV and support rationale for further immunotherapeutic interventions and vaccine development.
Eric S. Rosenberg, MD
Bibliography of Eric S. Rosenberg via PubMed
Lemieux – not in press yet
High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK. Open Forum Infect Dis. 2014 Dec 16;1(3):ofu108.
Detection of HIV gp120 in plasma during early HIV infection is associated with increased proinflammatory and immunoregulatory cytokines. Rychert J, Strick D, Bazner S, Robinson J, Rosenberg ES. AIDS Res Hum Retroviruses. 2010 Oct;26(10):1139-45.
Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection. Rosenberg ES, Graham BS, Chan ES, Bosch RJ, Stocker V, Maenza J, Markowitz M, Little S, Sax PE, Collier AC, Nabel G, Saindon S, Flynn T, Kuritzkes D, Barouch DH; AIDS Clinical Trials Group A5187 Team.. PLoS One. 2010 May 10;5(5):e10555.
Sequence variation occurs in CD4 epitopes during early HIV infection. Rychert J, Saindon S, Placek S, Daskalakis D, Rosenberg ES. J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):261-7.
Massachusetts General Hospital
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