MRI of brain superimposed over pathology slide

Andrew J. Cole, MD, Epilepsy Clinical Research

Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.

Lab Phone: 617-726-5904

Neurology Access Center 1-855-644-6387

Pediatric Epilepsy: 617-726-6540



Dr. Cole's current research is focused on advanced neuroimaging techniques and clinical research.

Dr. Cole has published extensively in clinical neurology, epilpesy, and basic neuroscience. In addition to research and clinical work, Dr. Cole lectures frequently throughout the United States and internationally, and has been a visiting professor at numerous institutions in the U.S.A. and abroad. 


Group Members

Andrew Cole

Principal Investigator

Andrew J. Cole, MD

  • Professor of Neurology,
    Harvard Medical School
  • Neurologist,
    Massachusetts General Hospital
  • Director,
    Massachusetts General Hospital Epilepsy Service

Research Coordinators

Research Projects

Research Projects

Functional MRI of language (Plasticity of Language Cortex)

Principle Investigator: Andrew Cole, MD
Co-Principle Investigator: Bradley R. Buchbinder, MD, Radiology

Advanced neuroimaging and MEG studies

Principle Investigator: Andrew Cole, MD
Co-Principle Investigator: Steve Stufflebeam, MD, Radiology

Clinical Trials Staus Updates - Closed to Enrollment

RNS™ System Long-term Treatment Clinical Investigation  (Neuropace)

The responsive-neurostimulator (RNS) long-term treatment study is investigating how well the RNS™ system, a surgically implanted device, works in patients over an extended period of time as treatment for partial onset seizures. In order to be eligible for this study all subjects must have completed participation in the initial trial of this device, RNS™ System Pivotal Clinical Investigation which began at MGH in 2005.

The RNS™ System (made by Neuropace Inc.) is designed to reduce the frequency and severity of medically uncontrolled partial onset seizures.  The RNS device has a small battery for power and a microprocessor that detects (senses) and stores electrical activity from the brain. When a seizure is detected, it responds by sending electrical stimulation through leads (tiny wires with electrodes) to a small part of the patient's brain to stop the seizure. This type of treatment is called responsive stimulation, but it is not yet known if it will work for the treatment of epilepsy.

Principle Investigator: Andrew Cole, MD
Research Coordinator: Samantha Donovan
For more information about the trial visit our sponsor’s website

Does memantine improve verbal memory task performance in patients with localization-related epilepsy and memory dysfunction?  A randomized, double-blind, placebo-controlled trial.

Many patients with epilepsy have memory deficits.  Unfortunately, the treatment options for memory dysfunction in patients with epilepsy are limited.  We are conducting a study to evaluate the effects of memantine, a medication used for the treatment of Alzheimer’s Disease, for the treatment of memory dysfunction in subjects with localization-related seizures.

Principle Investigator: Beth Leeman
Research Coordinator: Samantha Donovan


Research Positions

Read about and apply for residency, fellowship and observership programs at

All applicants should register with the Mass General Careers Web site at Request a list of current open positions at


Dr. Cole's publications are available via the following links:

Epilepsy Service Publications

PubMed publications



Contact Us

Epilepsy Service

Wang Ambulatory Care Center

15 Parkman Street8th Floor, Suite 835 Boston, MA 02114
  • Phone: 617-726-3311
  • Fax: 617-726-9250


  • 9:00 am to 5:00 pm

Consultation Second Opinion and Record Review

Phone: 617-726-3311

Epilepsy Monitoring Unit, First Seizure Clinic, Epilepsy Surgery

Phone: 617-726-3311

Pediatric Epilepsy

Phone: 617-726-6540
Pediatric Epilepsy website

Mailing Address

Andrew J. Cole, MD
Director, Mass General Hospital Epilepsy Service
Chief, Mass General Epilepsy Research Laboratory
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114


Clinical Trials

Samantha R. Donovan
Clinical Research Coordinator

Patient Frequently Asked Questions 

Download FAQ PDF

Q: What is your office contact information?
A: Phone: 617-726-3311
Fax: 617-726-9250

Q:  Where is the clinic location?
A: Wang Building, Floor 8, Suite 835

Q: What is your mailing address?
A: Attn: Epilepsy Unit
Wang 735
55 Fruit Street
Boston, MA 02114

Q: What is required in order to schedule a new patient appointment?
A: 2-3 most recent offices notes from local Neurologist
Most recent Brain MRI report (you will need to hand carry CD to appointment)
Most recent EEG report (you will need to hand carry CD to appointment)

Q: How can I obtain a copy of my medical records from the Epilepsy Unit?
A: You will need to complete the MGH Release of Information form and either fax or mail it back to our office. The release form can be found here.

Q: What is my doctor’s NPI number for an insurance referral?
A: Dr. Andrew Cole: 1043201502
Dr. Daniel Hoch: 1396727327
Dr. Sydney Cash: 1265415616
Dr. Jay Pathmanathan: 1164545299
Dr. Michael Brandon Westover: 1184653487
Dr. Lidia Veras Rocha de Moura: 1952664443
Dr. Deirdre O’Rourke: 1194092858
Dr. Arash Hadipour-Niktarash: 1265669253
Dr. Ammar Kheder: 1770925976
Dr. Nigel Pedersen: 1801023742
Dr. Aaron Struck: 1922238336
Dr. Gina Deck: 1255642286
Dr. Alice Lam: 1184949224
Dr. Rodrigo Garcia Zepeda: 1982923785
Tara Jennings, NP: 1508046723

Q: Where do I have my PCP fax my insurance referral to?
A: Referrals Office fax: 781-960-1265

Q: How do I know if my insurance will cover my visit?
A: Please call your insurance company to verify that your appointment or test will be covered. You can also contact our Financial Access Unit at 617-726-6828.

Q: How do I update my demographic and insurance information?
A: Please contact our Registration and Referrals Center at 866-211-6588

Q: How long will it take for me to receive my test results and how will they be communicated to me?
A: For lab work, radiology results, and EEG results please contact the office at least 48 hours after the test and we can let you know if the results are finalized. If they are, we will ask your provider to contact you to discuss the results with you.

Lab Phone: 617-726-5904

Neurology Access Center 1-855-644-6387

Pediatric Epilepsy: 617-726-6540

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