Dr. Cole's current research is focused on advanced neuroimaging techniques and clinical research.
Dr. Cole has published extensively in clinical neurology, epilpesy, and basic neuroscience. In addition to research and clinical work, Dr. Cole lectures frequently throughtout the United States and internationally, and has been a visiting professor at numerous institutions in the U.S.A. and abroad.
Andrew J. Cole, MD
Visit the Research page of the Epilepsy Service website for information about studies that are currently enrolling.
Functional MRI of language (Plasticity of Language Cortex)
Advanced neuroimaging and MEG studies
Principle Investigator: Andrew Cole, MD
Co-Principle Investigator: Steve Stufflebeam, MD, Radiology
Clinical Trials Staus Updates - Closed to Enrollment
RNS™ System Long-term Treatment Clinical Investigation (Neuropace)
The responsive-neurostimulator (RNS) long-term treatment study is investigating how well the RNS™ system, a surgically implanted device, works in patients over an extended period of time as treatment for partial onset seizures. In order to be eligible for this study all subjects must have completed participation in the initial trial of this device, RNS™ System Pivotal Clinical Investigation which began at MGH in 2005.
The RNS™ System (made by Neuropace Inc.) is designed to reduce the frequency and severity of medically uncontrolled partial onset seizures. The RNS device has a small battery for power and a microprocessor that detects (senses) and stores electrical activity from the brain. When a seizure is detected, it responds by sending electrical stimulation through leads (tiny wires with electrodes) to a small part of the patient's brain to stop the seizure. This type of treatment is called responsive stimulation, but it is not yet known if it will work for the treatment of epilepsy.
Does memantine improve verbal memory task performance in patients with localization-related epilepsy and memory dysfunction? A randomized, double-blind, placebo-controlled trial.
Many patients with epilepsy have memory deficits. Unfortunately, the treatment options for memory dysfunction in patients with epilepsy are limited. We are conducting a study to evaluate the effects of memantine, a medication used for the treatment of Alzheimer’s Disease, for the treatment of memory dysfunction in subjects with localization-related seizures.
Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education.
Apply for temporary positions (summer interns) through the Bulfinch Temporary Service Web site at http://www.massgeneral.org/careers/temporary.aspx. Search for all opportunities using ID# 2200484.
Hours: 9:00 am to 5:00 pm
Consultation Second Opinion and Record Review
Epilepsy Monitoring Unit, First Seizure Clinic, Epilepsy Surgery
Pediatric Epilepsy website
Andrew J. Cole, MD
Director, Mass General Hospital Epilepsy Service
Chief, Mass General Epilepsy Research Laboratory
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114
Samantha R. Donovan
Clinical Research Coordinator