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Research at Mass General
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Jordan Smoller, MD, ScD, is a Professor of Psychiatry at Harvard Medical School and a Professor in the Department of Epidemiology at the Harvard School of Public Health in Boston. He is the associate chief for research for the Mass General Department of Psychiatry and director of psychiatric genetics. He is director of the Psychiatric and Neurodevelopmental Genetics Unit in Mass General's Center for Human Genetics Research. Dr. Smoller also serves as co-director of the Genetics and Genomics Unit of the Mass General Clinical Research Program, is an Associate Member of the Broad Institute and a Senior Scientist at the Broad’s Stanley Center for Psychiatric Research.
Dr. Smoller earned his undergraduate degree at Harvard University and his medical degree at Harvard Medical School. After completing residency training in psychiatry at McLean Hospital, Dr. Smoller received masters and doctoral degrees in epidemiology at the Harvard School of Public Health. He also completed a postdoctoral fellowship in the National Institute of Mental Health (NIMH) Training Program in Psychiatric Genetics.
The focus of Dr. Smoller’s research interests has been the identification of genetic determinants of childhood and adult psychiatric disorders. Dr. Smoller and colleagues have also been studying genetic predictors of treatment response and the ways in which advances in genetics may impact clinical practice in psychiatry. He is an author of more than 200 scientific articles, book chapters and reviews; the recipient of numerous research awards; and a principal investigator on NIH-funded studies of the genetics of anxiety and the genetics of bipolar disorder, major depression and schizophrenia as well as brain imaging phenotypes.
See Dr. Smoller's publications
Assistant to Dr. Smoller:
Kristin JoyceSimches Research Building 185 Cambridge Street, CPZN-6Boston, MA 02114
Phone: 617-724-9076; Fax: 617-726-0830Email: firstname.lastname@example.org
Chia-Yen Chen, ScDChia-Yen Chen, ScD is a postdoctoral research fellow at both the PNGU and the Analytic and Translational Genetics Unit (ATGU) at Mass General. Dr. Chen is also affiliated with the Broad institute and the Harvard School of Public Health.Contact Dr. Chen
Tian Ge, PhDTian Ge is a postdoctoral research fellow at the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital / Harvard Medical School. His primary mentors are Jordan W. Smoller, MD, ScD and Mert R. Sabuncu, PhD.Contact Dr. Ge
Yen-Feng Lin is a Doctor of Science candidate in Epidemiology at the Harvard School of Public Health. He is also a board-certified psychiatrist in Taiwan. Yen-Feng’s research interest is focused on population genetics and genetic epidemiology of psychiatric disorders. He is working with Dr. Jordan Smoller studying the genetic overlaps between personality traits and cardiovascular disease (CVD) and the impact of personality traits on the association between genetics and CVD.
Yen-Feng received his MD degree from National Yang-Ming University, Taiwan. He received his MS degree in Epidemiology from the Harvard School of Public Health, and his MHS degree in Mental Health from the Johns Hopkins School of Public Health.
Contact Dr. Lin
Visiting InvestigatorsCarolina BlayaSoraya Seedat
Post-docsJennifer BarnettSarah BergenJennifer DiNieriLaramie DuncanErin DunnJie HuangPhil Hyoun LeeLauren McGrathAlisha PollastriNadia SolovieffMargaret WeyAnna Wiste
Program ManagersHolly SciortinoAlison Hoffnagle
Project ManagersFelecia CerratoStephen HaddadPatience GallagherFrancine MolayPriya MoorjaniBeth Rosen-SheidleyCatherine Shain
Office/Grants ManagersTalia GoldsmithJennifer PintoKatie SklarskyJamie WellerSamantha SchwartzErin Anderson
Graduate StudentsJessica Agnew-BlaisJian Kong
Laboratory ManagersJes FagernessBrian Galloway
Laboratory TechniciansSarah AndrusNatalie BalkemaAditi BasuJonathan ChaponisJacqueline CraneDaisy DaiAmanda GalenkampAllan GuineyBoyd GunnellJohn KennedyCatherine MayerfeldMiles NugentGerri TangrenJenna TarasoffSarah WeatherallAaron WolfLesley Yamaki
Research CoordinatorsStefanie BlockMaria BulzacchelliBridget ChakCaitlin ClementsYael DaiErica Gardner-SchusterConnie GuilleTamar KaimStephanie RacetteLisa SussweinLisa WatrasSydney WeillCandace WhiteMirella Young
Lab InternsNoura Al-JuffaliShannon BeanKatherine BeattieJennifer BourneSofia Chua-RubenfeldCatherine DemersTomer FinkelbergJohn HofferBrendan LangSam LevinLydia LewisSony MysoreCameron PeeblesSara RubensteinLiz RubinJared SoundyZeke Vainer
Undergraduate Thesis AdviseeMalorie Snider
Ashley Seiger, MSc, Program ManagerAshley Seiger brings over eight years of research experience to the Psychiatric and Neurodevelopmental Genetics Unit. Ashley received her BS in psychology and biology from Sacred Heart University and recently completed her masters in research administration from Emmanuel College.
Ruthann Hewett, Clinical Research CoordinatorRuthann Hewett graduated from Brandeis University in 2016 with a BA in psychology and health, science, society & policy. Her honors thesis examined mental illness and physical disability through the lens of the Stereotype Content Model. In the Smoller Lab, she is involved in studies that examine the genomic bases of disorders such as bipolar disorder and schizophrenia and develops innovative ways to use EHRs to predict suicide. Following her work in the Smoller Lab, Ruthann plans to pursue a PhD in clinical psychology with a focus on transcultural psychology and medical anthropology.
Tiffany Stanton, Clinical Research CoordinatorTiffany Stanton graduated from Boston College with a BA in Mathematics and a minor in General Education. She currently spends half of her time at PNGU and the other half at the Partners Healthcare Biobank, recruiting patients for the data repository. Following her position at Mass General, she hopes to obtain a masters degree in public health and continue to work in the healthcare industry.
The major goals of this project are to collect a large cohort of bipolar disorder cases and unaffected controls and construct a harmonized data source for genome-wide studies. The cohort will combind phenotypic data from the U.S. case-control sample with a parallel, separately funded European case-control sample.
PIs: Bruce Cohen and Dost Ongur The goal of this study is to examine genetic variants associated with psychotic disorders in a large cohort of patients with schizophrenia, schizoaffective disorder and bipolar disorder.
PI: Mark PollackThe major goals of this project are to compare the acute efficacy of d-cycloserine (DCS) augmentation relative to placebo augmentation of cognitive behavioral therapy (CBT) for the treatment of patients with panic disorder, examine the longer-term effects of DCS and to examine whether genetic loci strongly implicated in the neurobiology of fear conditioning and extinction are associated with extinction learning in response to CBT alone or CBT/DCS treatment.
Contact the Smoller Lab to learn more about our research.
See a complete list of Dr. Smoller's publications on PubMed.
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