Assistant Professor of Anesthesia, Harvard Medical School
Assistant Biochemist, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General HospitalResearch Areas
Description of ResearchOur lab focuses on two main research topics: First: to gain insight in the role of NO-sGC signaling in the regulation of blood pressure. We are evaluating the role of renin and 20-HETE signaling in the development of hypertension in mice deficient in sGC. Second: to study the role of NO-cGMP signaling in the development of open angle glaucoma. This project includes characterization of a new mouse model of glaucoma and identifying biomarkers and therapeutic targets in clinically relevant samples. In other projects, in collaboration with investigators in Belgium and the US (in the DACCPM, MGH, and other institutions), we are characterizing the role of NO-sGC signaling in stroke, cardiac dysfunction associated with systemic inflammation, gastrointestinal motility and erectile function, renal function, brain and lung development. Furthermore, we are using sGC mutant mice to study the mechanisms underlying the ability of inhaled NO to attenuate injury associated with myocardial infarction and cardiac arrest.
Buys Lab members, summer 2013
Emmanuel S. Buys, PhD
Ana Dordea, PhD
Sara Vandenwijngaert, PhD
Matias Page (summer student)
Mursal Hassan (summer student, MGH Bicentennial Program)
Laurel Tainsh (research assistant 2010-2012, DACCPM summer student 2013)
Public Transportation Access: yes
Disabled Access: yes
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