Massachusetts General Hospital

Assistant Professor of Anesthesia, Harvard Medical School

Assistant Biochemist, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General HospitalResearch Areas

• Elucidate the molecular mechanism underlying the strain- and gender-specific hypertension associated with impaired nitric oxide-soluble guanylate cyclase (NO-sGC) signaling.
• Elucidate the role of impaired NO-sGC signaling in the development of primary open angle glaucoma.
• Physiologic profiling of genetic variants in the genes encoding sGC and natriuretic peptides
• Use emerging genomic information to characterize NO signaling in the Weddell seal.

Description of ResearchOur lab focuses on two main research topics: First: to gain insight in the role of NO-sGC signaling in the regulation of blood pressure. We are evaluating the role of renin and 20-HETE signaling in the development of hypertension in mice deficient in sGC. Second: to study the role of NO-cGMP signaling in the development of open angle glaucoma. This project includes characterization of a new mouse model of glaucoma and identifying biomarkers and therapeutic targets in clinically relevant samples. In other projects, in collaboration with investigators in Belgium and the US (in the DACCPM, MGH, and other institutions), we are characterizing the role of NO-sGC signaling in stroke, cardiac dysfunction associated with systemic inflammation, gastrointestinal motility and erectile function, renal function, brain and lung development. Furthermore, we are using sGC mutant mice to study the mechanisms underlying the ability of inhaled NO to attenuate injury associated with myocardial infarction and cardiac arrest.

Funding Information

• 10SDG2610313–AHA Scientist Development Grant (PI: Buys) 01/01/10 – 12/31/13
• 1R01-HL110378-01A1 (PI: Ichinose/Bloch) 04/01/12 – 03/31/17
• R01 EY022746-01 (PI: Buys) 09/15/12 – 08/31/17

Principal Investigator
    Emmanuel S. Buys, PhD

Postdoctoral Fellows
    Ana Dordea, PhD
    Sara Vandenwijngaert, PhD (start date: 08/01/2013)

Research Assistants
    Robert Tainsh
    Daniel Nathan

Summer Intern
    Laurel Tainsh
    Mursal Hassan

Alumni
    Amanda Graveline
    Kristen Rauwerdink
    Sarah Hayton
    Matias Page (summer student)
    Laurel Tainsh

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Anesthesia, Critical Care and Pain Medicine

Phone: 617-726-3030

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