Research Centers

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Emmanuel Buys, PhD

Emmanuel Buys investigates the role that soluble guanylate cyclase (sGC) plays in the development of both cardiovascular disease and open angle glaucoma, testing sGC-targeted strategies for disease prevention, detection and treatment.

Emmanuel Buys, PhD
Assistant Professor of Anesthesia, Harvard Medical School
Assistant Biochemist, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital

Description of Research

Our lab focuses on therapeutically targeting nitric oxide (NO) and cyclic guanosine monophosphate (GMP) signaling in a variety of disorders. Current research topics include:

  • Elucidating the molecular mechanisms underlying the strain- and gender-specific hypertension associated with impaired NO-cGMP signaling. This project includes the characterization of renin and 20-hydroxyeicosatetraenoic acid (20-HETE) systems as blood-pressure modifying signaling mechanisms in a setting of impaired NO-cGMP signaling (e.g. in soluble guanylate cyclase (sGC)-deficient mice)
  • Elucidating the role of impaired NO-cGMP signaling in the development of primary open angle glaucoma. This project includes characterization of a new mouse model of glaucoma and identifying biomarkers and therapeutic targets in clinically relevant samples
  • Physiologic profiling of genetic variants in the genes encoding sGC and natriuretic peptides (NPs)
  • Using emerging genomic information to characterize NO signaling in the Weddell seal
  • Regulating cGMP signaling by microRNAs (miRs). This project aims to identify and therapeutically target miRs that regulate mRNAs encoding atrial natriuretic peptide (an activator of particulate guanylate cyclases), NO synthase, and soluble guanylate cyclase
  • Characterizing the role of NO-cGMP signaling in stroke, gastrointestinal motility, erectile function, renal function, brain and lung development, and cardiac dysfunction associated with systemic inflammation (in collaboration with investigators in Europe and the US). Furthermore, we are using sGC mutant mice to study the mechanisms underlying the ability of inhaled NO to attenuate injury associated with myocardial infarction and cardiac arrest

Funding Information

  • 1R01-HL110378-01A1 (PI: Ichinose/Bloch) 04/01/12–03/31/17
  • R01 EY022746-01 (PI: Buys) 09/15/12–08/31/17
  • 1R01-HL11933-01A1 (PI: Newton/Cheh) 09/01/13–08/31/17
  • DACCPM Clinical Research Grant (PI: Buys) 01/01/14–12/31/15 

Buys Lab members, summer 2013

Buys Lab members, summer 2013

Principal Investigator

  • Emmanuel S. Buys, PhD

Lecturer

  • Allyson Hindle, PhD

Postdoctoral Fellows

  • Ana Dordea, PhD
  • Sara Vandenwijngaert, PhD

Research Assistants

  • Robert Tainsh
  • Daniel Nathan
  • Kaitlin Allen

Master Student

  • Wolfgang Sebastian Lieb

Summer Student

  • Shananssa Percy

Alumni

  • Amanda Graveline
  • Kristen Rauwerdink
  • Sarah Hayton
  • Matias Page (summer student)
  • Mursal Hassan (summer student, MGH Bicentennial Program)
  • Laurel Tainsh (research assistant 2010-2012, DACCPM summer student 2013)
  • Jessica Meir (Junior faculty 2012-2013, currently NASA astronaut candidate)

Anesthesia, Critical Care and Pain Medicine

Gray-Bigelow 444
55 Fruit St.
Boston, MA 02114

Phone: 617-726-3030

Public Transportation Access: yes
Disabled Access: yes

For more information, please visit our website.