Assistant Professor of Anesthesia, Harvard Medical School
Assistant Biochemist, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General HospitalResearch Areas
Description of ResearchOur lab focuses on two main research topics: First: to gain insight in the role of NO-sGC signaling in the regulation of blood pressure. We are evaluating the role of renin and 20-HETE signaling in the development of hypertension in mice deficient in sGC. Second: to study the role of NO-cGMP signaling in the development of open angle glaucoma. This project includes characterization of a new mouse model of glaucoma and identifying biomarkers and therapeutic targets in clinically relevant samples. In other projects, in collaboration with investigators in Belgium and the US (in the DACCPM, MGH, and other institutions), we are characterizing the role of NO-sGC signaling in stroke, cardiac dysfunction associated with systemic inflammation, gastrointestinal motility and erectile function, renal function, brain and lung development. Furthermore, we are using sGC mutant mice to study the mechanisms underlying the ability of inhaled NO to attenuate injury associated with myocardial infarction and cardiac arrest.
Emmanuel S. Buys, PhD
Ana Dordea, PhD
Sara Vandenwijngaert, PhD (start date: 08/01/2013)
Matias Page (summer student)
Public Transportation Access: yes
Disabled Access: yes
For more information, please visit our website.
Proto magazine stakes its ground on medicine's leading edge, reporting back from the frontiers of research and practice - exploring breakthroughs, dissecting controversies and opening a forum for informed debate.
Discover the largest hospital-based research program in the U.S. and how clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and bring the latest advances to patient care
Discover what makes Massachusetts General Hospital not just one of the best places to receive patient care but also one of the best places to work.