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Instructor of Anesthesia, Harvard Medical SchoolResearch Areas
Description of ResearchMy research interest has been focused on blood transfusion and blood substitutes. We have developed two animal models of blood storage, one in the mouse and one in the sheep. We have characterized the storage models in vitro and in vivo. Most recently, we have studied of transfusion fresh RBCs and stored RBCs to resuscitate mice and sheep from hemorrhagic shock. We have been working on selectively oxidizing the supernatant oxy-hemoglobin of stored RBCs to met-hemoglobin, and, thereby, preventing the adverse responses to stored RBC transfusion. My goal is to make transfusion of human blood stored for prolonged periods a safer clinical process.
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