Instructor in Anaesthesia, Harvard Medical School
Assistant in Research, Department of Anesthesia, Critical Care and Pain Medicine, Mass General
Description of Research
Our research aims to understand the mechanisms by which the mutation in a serine/threonine kinase receptor for bone morphogenetic proteins (BMPs), specifically the BMP type 2 receptor (BMPR2), participates in the development of Primary Pulmonary Arterial Hypertension (PAH). Among many functions, BMPs are known to be key regulators in vascular and lung development. Moreover, during adult life, BMPs are thought to maintain the vasculature integrity of the lung. Elucidating how mutations in BMPR2 lead to PAH will help us to find new therapeutical approaches to treat this life-threatening condition.
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